Q9JLR5
PR
Gene name |
Tcf23 (Out) |
Protein name |
Transcription factor 23 |
Names |
TCF-23, Basic helix-loop-helix transcription factor OUT, Ovary, uterus and testis protein |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:69852 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9JLR5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9JLR5-F1 | Predicted | AlphaFoldDB |
16 variants for Q9JLR5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs32453296 | 38 | R>G | No | EVA | |
| rs260916856 | 41 | Q>R | No | EVA | |
| rs3388752093 | 79 | E>G | No | EVA | |
| rs3388752110 | 89 | K>T | No | EVA | |
| rs3395030913 | 138 | P>R | No | EVA | |
| rs3395298659 | 138 | P>T | No | EVA | |
| rs3395298674 | 140 | W>R | No | EVA | |
| rs3388749283 | 154 | K>E | No | EVA | |
| rs3388751921 | 156 | W>R | No | EVA | |
| rs3388737144 | 164 | A>T | No | EVA | |
| rs3388746960 | 174 | S>Y | No | EVA | |
| rs225550750 | 175 | T>S | No | EVA | |
| rs3388754426 | 181 | G>D | No | EVA | |
| rs32453933 | 185 | K>R | No | EVA | |
| rs3388748919 | 196 | A>T | No | EVA | |
| rs32453930 | 206 | F>L | No | EVA |
No associated diseases with Q9JLR5
1 regional properties for Q9JLR5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Myc-type, basic helix-loop-helix (bHLH) domain | 94 - 152 | IPR011598 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| euchromatin | A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| protein dimerization activity | The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. |
| RNA polymerase II transcription regulatory region sequence-specific DNA binding | Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II. |
| RNA polymerase II-specific DNA-binding transcription factor binding | Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription. |
| transcription regulator inhibitor activity | A molecular function regulator that inhibits the activity of a transcription regulator via direct binding and/or post-translational modification. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| decidualization | The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta. |
| developmental process | A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition. |
| muscle organ development | The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work. |
| negative regulation of muscle cell differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| positive regulation of gene expression | Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0VCE2 | HAND1 | Heart- and neural crest derivatives-expressed protein 1 | Bos taurus (Bovine) | PR |
| Q90691 | HAND1 | Heart- and neural crest derivatives-expressed protein 1 | Gallus gallus (Chicken) | PR |
| O96004 | HAND1 | Heart- and neural crest derivatives-expressed protein 1 | Homo sapiens (Human) | PR |
| Q64279 | Hand1 | Heart- and neural crest derivatives-expressed protein 1 | Mus musculus (Mouse) | PR |
| P97832 | Hand1 | Heart- and neural crest derivatives-expressed protein 1 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSQEATEAPA | MPGEGHGHNK | AKARWLLGTD | RKRSRINRTR | QDLWEDTSWS | NHRLSRATSA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PRGTRARGTA | HGRSEASPEN | AARERTRVKT | LRQAFLALQA | ALPAVPPDTK | LSKLDVLVLA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TSYIAHLTRT | LGHELPGPAW | PPFVRGLRYL | HPLKKWPMRS | RLYAGGLGCS | DLDSTTAITT |
| 190 | 200 | ||||
| GQRCKDAELG | SQDSVAAESL | LTSPAFGNK |