Q9JKY0
PR
Gene name |
Cnot9 |
Protein name |
CCR4-NOT transcription complex subunit 9 |
Names |
Cell differentiation protein RQCD1 homolog, Rcd-1, EPO-induced protein FL10 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:58184 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9JKY0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9JKY0-F1 | Predicted | AlphaFoldDB |
16 variants for Q9JKY0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388477978 | 11 | P>S | No | EVA | |
| rs3388477707 | 21 | K>R | No | EVA | |
| rs3388477883 | 80 | P>L | No | EVA | |
| rs3390105496 | 94 | L>* | No | EVA | |
| rs3390204389 | 94 | L>I | No | EVA | |
| rs3388478714 | 102 | S>P | No | EVA | |
| rs3388478549 | 106 | T>I | No | EVA | |
| rs3388478291 | 115 | I>F | No | EVA | |
| rs3388479936 | 118 | F>I | No | EVA | |
| rs3388478381 | 120 | Y>* | No | EVA | |
| rs3388478442 | 131 | P>H | No | EVA | |
| rs3388477008 | 151 | E>Q | No | EVA | |
| rs3388479953 | 157 | F>L | No | EVA | |
| rs3388478500 | 186 | L>F | No | EVA | |
| rs3388477685 | 273 | K>R | No | EVA | |
| rs3388478964 | 294 | I>N | No | EVA |
No associated diseases with Q9JKY0
5 regional properties for Q9JKY0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | C2 domain | 1 - 115 | IPR000008-1 |
| domain | C2 domain | 124 - 247 | IPR000008-2 |
| domain | von Willebrand factor, type A | 289 - 495 | IPR002035 |
| domain | Copine, C-terminal | 263 - 524 | IPR010734 |
| domain | Copine, C2B domain | 139 - 251 | IPR037768 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| CCR4-NOT complex | The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8. |
| CCR4-NOT core complex | The core of the CCR4-NOT complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| P-body | A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| epidermal growth factor receptor binding | Binding to an epidermal growth factor receptor. |
| kinase binding | Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group. |
| nuclear receptor coactivator activity | A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. |
| protein domain specific binding | Binding to a specific domain of a protein. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| cytokine-mediated signaling pathway | The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| gene silencing by RNA | A process in which an RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation. |
| mRNA catabolic process | The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes. |
| negative regulation of intracellular estrogen receptor signaling pathway | Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway. |
| negative regulation of translation | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. |
| positive regulation of epidermal growth factor receptor signaling pathway | Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity. |
| positive regulation of peptidyl-serine phosphorylation | Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A7MB47 | CNOT9 | CCR4-NOT transcription complex subunit 9 | Bos taurus (Bovine) | PR |
| Q92600 | CNOT9 | CCR4-NOT transcription complex subunit 9 | Homo sapiens (Human) | PR |
| Q5PQL2 | Cnot9 | CCR4-NOT transcription complex subunit 9 | Rattus norvegicus (Rat) | PR |
| Q6P819 | cnot9 | CCR4-NOT transcription complex subunit 9 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q6NWL4 | cnot9 | CCR4-NOT transcription complex subunit 9 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MHSLATAAPV | PTALAQVDRE | KIYQWINELS | SPETRENALL | ELSKKRESVP | DLAPMLWHSF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GTIAALLQEI | VNIYPSINPP | TLTAHQSNRV | CNALALLQCV | ASHPETRSAF | LAAHIPLFLY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PFLHTVSKTR | PFEYLRLTSL | GVIGALVKTD | EQEVINFLLT | TEIIPLCLRI | MESGSELSKT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VATFILQKIL | LDDTGLAYIC | QTYERFSHVA | MILGKMVLQL | SKEPSARLLK | HVVRCYLRLS |
| 250 | 260 | 270 | 280 | 290 | |
| DNPRAREALR | QCLPDQLKDT | TFAQVLKDDT | TTKRWLAQLV | KNLQEGQVTD | PRGIPLPPQ |