AiPD: Autoinhibited Protein Database

Gene name	Plekho1
Protein name	Pleckstrin homology domain-containing family O member 1
Names	PH domain-containing family O member 1
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:67220
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

188-259 (Predicted disordered autoinhibitory region) PR

188-259 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9JIY0-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388651663	49	G>D	No	EVA
rs3388651826	54	V>I	No	EVA
rs3388644516	74	Y>F	No	EVA
rs3388644479	116	P>L	No	EVA
rs3388650778	117	E>D	No	EVA
rs3388646046	118	E>D	No	EVA
rs3393369147	142	T>P	No	EVA
rs3388642510	196	P>H	No	EVA
rs3388648081	248	K>M	No	EVA
rs30406266	251	P>S	No	EVA
rs3388651667	273	E>K	No	EVA
rs3388647988	277	Q>L	No	EVA
rs3388644468	282	P>S	No	EVA
rs3388646537	289	Q>H	No	EVA
rs216080491	295	P>A	No	EVA
rs3388648906	333	R>L	No	EVA
rs3388637968	341	S>P	No	EVA
rs3388630627	342	P>A	No	EVA
rs218021928	346	E>A	No	EVA
rs3388650194	353	E>G	No	EVA

Type	Name	Position	InterPro Accession
domain	Pleckstrin homology domain	20 - 133	IPR001849

		Description
EC Number
Subcellular Localization	Cell membrane ; Peripheral membrane protein Nucleus Cytoplasm	Predominantly localized to the plasma membrane through the binding to phosphatidylinositol 3-phosphate In C2C12 cells, with the absence of growth factor, it is found in the nucleus It rapidly translocates to the plasma membrane after insulin stimulation In response to TNF, it translocates from the plasma membrane to the cytoplasm and then to the nucleus accompanied by cleavage by caspase-3 However, the subcellular location is highly dependent of the cell type, and this explains why it is found exclusively at the plasma membrane, in some type of cells
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
muscle cell projection membrane	The portion of the plasma membrane surrounding a muscle cell projection.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
ruffle membrane	The portion of the plasma membrane surrounding a ruffle.

Name	Definition
No GO annotations for molecular function

Name	Definition
lamellipodium morphogenesis	A process that is carried out at the cellular level and in which the structure of a lamellipodium is organized.
myoblast fusion	A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
myoblast migration	The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
regulation of cell shape	Any process that modulates the surface configuration of a cell.
regulation of myoblast fusion	Any process that modulates the frequency, rate or extent of myoblast fusion.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8K124	Plekho2	Pleckstrin homology domain-containing family O member 2	Mus musculus (Mouse)	PR