Q8K124
Gene name |
Plekho2 (Plekhq1) |
Protein name |
Pleckstrin homology domain-containing family O member 2 |
Names |
PH domain-containing family O member 2, Pleckstrin homology domain-containing family Q member 1, PH domain-containing family Q member 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:102595 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8K124
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8K124-F1 | Predicted | AlphaFoldDB |
25 variants for Q8K124
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389061596 | 19 | A>S | No | EVA | |
| rs3389051565 | 39 | R>S | No | EVA | |
| rs3389057111 | 40 | Y>N | No | EVA | |
| rs3389020981 | 41 | L>S | No | EVA | |
| rs3389061649 | 46 | A>T | No | EVA | |
| rs3389028869 | 62 | T>K | No | EVA | |
| rs3389051397 | 72 | Q>H | No | EVA | |
| rs3389034419 | 79 | K>M | No | EVA | |
| rs3389042136 | 139 | E>K | No | EVA | |
| rs3399950503 | 141 | V>M | No | EVA | |
| rs3389042224 | 163 | V>A | No | EVA | |
| rs213751204 | 197 | P>S | No | EVA | |
| rs3389054934 | 203 | A>T | No | EVA | |
| rs3389052816 | 223 | K>M | No | EVA | |
| rs262450702 | 240 | G>E | No | EVA | |
| rs3389061663 | 243 | P>H | No | EVA | |
| rs3389047749 | 298 | E>K | No | EVA | |
| rs3389055956 | 344 | E>* | No | EVA | |
| rs247837960 | 345 | P>L | No | EVA | |
| rs3389034499 | 347 | Q>H | No | EVA | |
| rs3389028887 | 351 | N>I | No | EVA | |
| rs3389057053 | 398 | D>N | No | EVA | |
| rs233230211 | 435 | V>M | No | EVA | |
| rs3399702215 | 444 | C>W | No | EVA | |
| rs3389042230 | 482 | K>N | No | EVA |
No associated diseases with Q8K124
1 regional properties for Q8K124
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Pleckstrin homology domain | 18 - 122 | IPR001849 |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| macrophage apoptotic process | Any apoptotic process in a macrophage, a mononuclear phagocyte present in a variety of tissues. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9JIY0 | Plekho1 | Pleckstrin homology domain-containing family O member 1 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEEESIKEGS | EKPRGARTAD | KAGWIKKSSG | GLLGLWKDRY | LLLCQAQLLV | YENEDEQKCV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ETVELGSYEK | CQDLRTLLKR | KHHRFILLRS | PGNKVSDIKF | QAPSGEEKES | WIKALNEGIN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RGKNKAFDEV | KVDKTCALEH | VTRNRVRGGQ | RRRPPTRIHL | KEVASAASDG | LSRLDLDVPD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SGPPVFAPLS | DISEDQPQEP | PRALMPPVKP | SPGPETSAVE | DSKETPAGER | ALTPDSASSG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ANPESQEDAE | TPAKEDSDVK | SLPNSTLSEK | LKVSWENPSP | EKPSAPESAQ | LSSSETPEAT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PRESKKPPAP | PPKILSEKMK | ACMSGVDASG | SSQSSEAPET | TSPEPTQVSV | NGMDDGPESA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LQAMGIPGPA | PEDAAASPAL | PFSDLPSQFH | PRSSSLGDLL | RESPQHPRLP | KEKLYRAQLE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VKVASKQTEK | LLNQVLGSEP | PPVCAESLLS | QAVEQLRQAT | QVLQEMRDLG | ELNQETPGLV |
| 490 | |||||
| QKRKELVTLY | RRSAP |