Q9JHU4

PR
Gene name
Dync1h1 (Dhc1, Dnch1, Dnchc1, Dyhc)
Protein name
Cytoplasmic dynein 1 heavy chain 1
Names
Cytoplasmic dynein heavy chain 1 , Dynein heavy chain, cytosolic
Species
Oryza sativa subsp japonica (Rice)
KEGG Pathway
mmu:13424
EC number
2.7.12.2: Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

240-830 (Dynein Tail) SS

Target domain

1899-3093 (Motor domain)

Relief mechanism

Partner binding

Assay

1319-1717 (Dynein heavy chain linker) SS

Target domain

1899-3093 (Motor domain)

Relief mechanism

Partner binding

Assay

1866-4219 (Motor domain) SS

Target domain

1866-4219 (Motor domain in other dynein-1)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

7 structures for Q9JHU4

Entry ID Method Resolution Chain Position Source
3ERR X-ray 227 A A/B 3260-3427 PDB
3J1T EM 970 A A 3264-3427 PDB
3J1U EM 970 A A 3264-3427 PDB
3WUQ X-ray 350 A A 3207-3483 PDB
5AYH X-ray 301 A A 3207-3475 PDB
6RZA EM 540 A PDB
6RZB EM 500 A C 3270-3418 PDB

219 variants for Q9JHU4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389259422 95 E>* No EVA
rs3389191781 123 I>N No EVA
rs3389270517 130 S>* No EVA
rs3389233043 132 Q>R No EVA
rs3389275060 141 D>E No EVA
rs3389275008 178 P>H No EVA
rs3389262897 206 P>Q No EVA
rs240870455 219 Y>H No EVA
rs3389191750 223 E>Q No EVA
rs244357461 232 D>E No EVA
rs3389259019 250 W>* No EVA
rs3389228848 251 I>N No EVA
rs3389267808 303 K>R No EVA
rs3389255954 311 T>N No EVA
rs3389220242 313 S>G No EVA
rs3389258952 365 I>N No EVA
rs3389246192 390 L>P No EVA
rs3389257673 394 L>M No EVA
rs3389255890 429 Q>* No EVA
rs3389258990 462 D>Y No EVA
rs33345603 517 A>T No EVA
580 F>Y LOA [UniProt] No
rs3389253756 607 I>L No EVA
rs3389191698 621 F>L No EVA
rs3389274983 655 Q>* No EVA
rs3389275043 681 K>M No EVA
rs3389253744 690 K>M No EVA
rs3389220264 748 V>I No EVA
rs3389259426 790 C>Y No EVA
rs3389267807 802 L>I No EVA
rs3389253780 824 S>F No EVA
rs3389220244 837 T>S No EVA
rs3389220172 853 E>K No EVA
rs3389262879 886 L>Q No EVA
rs3389261605 897 W>* No EVA
rs3389255887 945 H>Q No EVA
rs3389220099 956 V>M No EVA
rs263635107 986 A>S No EVA
rs3389257626 990 V>F No EVA
rs3389274981 995 P>S No EVA
1055 Y>C CRA1 [UniProt] No
rs33347673 1075 N>H No EVA
rs3389259418 1097 K>E No EVA
rs3389262850 1104 V>M No EVA
rs3389259335 1106 D>V No EVA
rs3389220211 1113 K>M No EVA
rs3389255903 1274 A>D No EVA
rs3389246191 1279 T>S No EVA
rs3389246199 1392 M>T No EVA
rs3389259390 1394 I>T No EVA
rs3403832724 1396 M>V No EVA
rs3389191738 1397 L>S No EVA
rs3389275015 1404 E>K No EVA
rs3389233076 1455 M>K No EVA
rs3389267804 1521 W>G No EVA
rs3389259376 1524 K>R No EVA
rs3389255965 1532 F>L No EVA
rs3389257600 1569 I>V No EVA
rs3389261593 1585 L>R No EVA
rs3389233108 1610 Q>* No EVA
rs3389246208 1642 S>G No EVA
rs3389262862 1695 K>Q No EVA
rs3389275007 1699 W>R No EVA
rs3389191713 1739 W>R No EVA
rs3389246239 1754 I>K No EVA
rs3389233089 1756 W>R No EVA
rs3389246176 1800 P>H No EVA
rs3389228860 1804 R>L No EVA
rs222239631 1831 A>S No EVA
rs3389262845 1835 E>G No EVA
rs3389259369 1844 F>Y No EVA
rs3389255958 1854 Q>* No EVA
rs3389246218 1868 F>S No EVA
rs3389275028 1884 D>H No EVA
rs3389257654 1903 F>S No EVA
rs3389255934 1905 P>H No EVA
rs3389233024 1924 F>L No EVA
rs3389191708 1933 T>P No EVA
rs3389270438 1969 V>I No EVA
rs3389191745 2031 K>* No EVA
rs3403009898 2033 L>R No EVA
rs3403060400 2035 R>L No EVA
rs3403743100 2035 R>W No EVA
rs3412945730 2072 K>R No EVA
rs3404044280 2117 G>E No EVA
rs3389267799 2177 R>Q No EVA
rs3389228842 2182 K>N No EVA
rs3403735066 2217 G>C No EVA
rs3403713929 2217 G>V No EVA
rs3389246210 2232 W>S No EVA
rs3389267821 2253 D>E No EVA
rs3389275045 2257 I>N No EVA
rs3389233061 2283 R>* No EVA
rs3389261092 2285 I>N No EVA
rs3389220195 2288 N>I No EVA
rs3389259360 2288 N>K No EVA
rs3389261613 2340 M>V No EVA
rs3389233053 2362 F>L No EVA
rs3389193050 2362 F>Y No EVA
rs3389259394 2373 F>L No EVA
rs3389262899 2402 E>K No EVA
rs3389253819 2414 Q>K No EVA
rs3389255883 2424 Y>* No EVA
rs3389261138 2434 A>T No EVA
rs3389233094 2504 S>N No EVA
rs3389274995 2509 R>S No EVA
rs3404044760 2517 R>L No EVA
rs3389261081 2521 T>P No EVA
rs3389275054 2530 V>L No EVA
rs3389220209 2533 I>T No EVA
rs3389253798 2534 D>H No EVA
rs3389255878 2558 H>Q No EVA
rs3389257606 2561 A>T No EVA
rs3389261598 2561 A>V No EVA
rs3389253814 2574 R>G No EVA
rs3389259355 2580 Y>* No EVA
rs3389270489 2592 C>Y No EVA
rs3550078755 2658 V>G No EVA
rs3389261104 2665 N>I No EVA
rs3389246168 2675 Q>H No EVA
rs3389263758 2707 V>A No EVA
rs3389257611 2711 N>K No EVA
rs3389257643 2722 S>L No EVA
rs3389257641 2763 Y>* No EVA
rs3389275049 2774 F>I No EVA
rs3389261073 2789 H>L No EVA
rs3389260101 2823 W>* No EVA
rs3389255933 2929 G>C No EVA
rs3389261643 2930 H>L No EVA
rs3389260021 2932 L>I No EVA
rs3389263718 2969 D>E No EVA
rs3389233097 2970 F>Y No EVA
rs3389267770 2971 D>E No EVA
rs3389260044 2972 E>D No EVA
rs3389234565 2981 S>T No EVA
rs3389263725 3048 L>F No EVA
rs3389270474 3083 L>P No EVA
rs3389261085 3126 V>F No EVA
rs3389261127 3128 Y>* No EVA
rs3389260082 3154 Q>* No EVA
rs3389270492 3158 R>L No EVA
rs3389275053 3203 L>P No EVA
rs3389246201 3275 S>N No EVA
rs3389228818 3313 A>T No EVA
rs3412177896 3359 D>E No EVA
rs3389261621 3368 N>K No EVA
rs3389193124 3375 Y>H No EVA
rs3403060404 3406 R>L No EVA
rs3403060404 3406 R>LIPQGLHSL* No EVA
rs3389261563 3424 N>Y No EVA
rs3389253774 3442 I>T No EVA
rs3389257631 3474 T>S No EVA
rs3389228812 3494 F>L No EVA
rs3389246226 3494 F>S No EVA
rs3389228857 3532 H>Q No EVA
rs3389260077 3543 T>I No EVA
rs3389270432 3549 E>K No EVA
rs3389228832 3553 N>S No EVA
rs3389246203 3557 R>C No EVA
rs3389253811 3572 T>I No EVA
rs3389263742 3595 T>I No EVA
rs3389234645 3627 F>I No EVA
rs3389220246 3640 D>Y No EVA
rs3389267744 3692 S>F No EVA
rs3389257665 3702 T>I No EVA
rs3389220251 3714 V>A No EVA
rs3389275047 3721 D>E No EVA
rs3389263719 3742 Q>H No EVA
rs3389255908 3763 T>N No EVA
rs3389220132 3785 T>I No EVA
rs3389260043 3791 E>* No EVA
rs3389261106 3812 T>S No EVA
rs3389193102 3839 Y>F No EVA
rs29181736 3856 I>V No EVA
rs3389260086 3874 L>Q No EVA
rs3389274999 3887 R>S No EVA
rs3389275037 3909 G>W No EVA
rs248062748 3919 T>A No EVA
rs3389220213 3921 K>I No EVA
rs3403833595 3947 A>G No EVA
rs3389270488 3979 T>I No EVA
rs3389275041 3982 G>R No EVA
rs3389260069 4009 T>A No EVA
rs3403060403 4011 L>I No EVA
rs3389234606 4017 S>T No EVA
rs3389257661 4019 M>K No EVA
rs3389234647 4060 Q>H No EVA
rs3389275035 4093 M>I No EVA
rs3403909151 4128 I>M No EVA
rs3402355053 4129 N>I No EVA
rs3389257642 4138 R>H No EVA
rs3389253801 4139 A>V No EVA
rs3389234610 4143 F>S No EVA
rs3389257640 4211 R>Q No EVA
rs3389255953 4217 V>A No EVA
rs3389260091 4222 D>N No EVA
rs3389261152 4245 M>L No EVA
rs3389234572 4261 R>H No EVA
rs3403743084 4265 T>S No EVA
rs1132395785 4267 L>Q No EVA
rs3389228789 4292 I>L No EVA
rs3389220185 4311 P>S No EVA
rs3389228774 4312 D>N No EVA
rs3403909161 4333 Q>* No EVA
rs3403507095 4333 Q>L No EVA
rs3389270501 4339 S>N No EVA
rs3389261140 4352 D>V No EVA
rs33352852 4383 S>F No EVA
rs3389253794 4388 L>I No EVA
rs3389270113 4389 I>T No EVA
rs3389263709 4398 R>H No EVA
rs3389260048 4413 R>K No EVA
rs3389260025 4435 V>M No EVA
rs3389220217 4463 S>P No EVA
rs3389220184 4464 H>L No EVA
rs3389260090 4475 Q>E No EVA
rs3389246190 4516 E>A No EVA
rs3389193097 4534 L>M No EVA
rs3389261622 4611 F>Y No EVA

No associated diseases with Q9JHU4

9 regional properties for Q9JHU4

Type Name Position InterPro Accession
domain Protein kinase domain 134 - 392 IPR000719
domain EF-hand domain 435 - 506 IPR002048-1
domain EF-hand domain 507 - 576 IPR002048-2
active_site Serine/threonine-protein kinase, active site 254 - 266 IPR008271
binding_site Protein kinase, ATP binding site 140 - 167 IPR017441
binding_site EF-Hand 1, calcium-binding site 448 - 460 IPR018247-1
binding_site EF-Hand 1, calcium-binding site 484 - 496 IPR018247-2
binding_site EF-Hand 1, calcium-binding site 520 - 532 IPR018247-3
binding_site EF-Hand 1, calcium-binding site 554 - 566 IPR018247-4

Functions

Description
EC Number 2.7.12.2 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

13 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
axon cytoplasm Any cytoplasm that is part of a axon.
axonemal dynein complex A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.
cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic dynein complex Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains.
cytoplasmic microtubule Any microtubule in the cytoplasm of a cell.
dynein complex Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity.
filopodium Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
manchette A tubular array of microtubules that extends from the perinuclear ring surrounding the spermatid nucleus to the flagellar axoneme. The manchette may also contain F-actin filaments.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction
dynein intermediate chain binding Binding to an intermediate chain of the dynein complex.
dynein light intermediate chain binding Binding to a light intermediate chain of the dynein complex.
minus-end-directed microtubule motor activity A motor activity that generates movement along a microtubule toward the minus end, driven by ATP hydrolysis.

14 GO annotations of biological process

Name Definition
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
cilium movement The directed, self-propelled movement of a cilium.
cytoplasmic microtubule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell.
establishment of spindle localization The directed movement of the spindle to a specific location in the cell.
mitotic spindle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
nuclear migration The directed movement of the nucleus to a specific location within a cell.
P-body assembly The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body.
positive regulation of cold-induced thermogenesis Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
positive regulation of intracellular transport Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells.
positive regulation of spindle assembly Any process that activates or increases the frequency, rate or extent of spindle assembly.
regulation of metaphase plate congression Any process that modulates the rate, frequency, or extent of metaphase plate congression, the alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle.
regulation of mitotic spindle organization Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
retrograde axonal transport The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons.
stress granule assembly The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P36022 DYN1 Dynein heavy chain, cytoplasmic Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) EV
P37276 Dhc64C Dynein heavy chain, cytoplasmic Drosophila melanogaster (Fruit fly) SS
Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 Homo sapiens (Human) EV
P38650 Dync1h1 Cytoplasmic dynein 1 heavy chain 1 Rattus norvegicus (Rat) SS
Q19020 dhc-1 Dynein heavy chain, cytoplasmic Caenorhabditis elegans SS
10 20 30 40 50 60
MRGKKPHKEL KLSVPAQETP VDKFLTASGT FKDGELRLNQ RGLQLISEET ADEPQSTNLK
70 80 90 100 110 120
VEDVQLSMDD LEMIQVIGKG SGGIVQLVRH KWVGTLYALK GIQMNIQEAV RKQIVQELKI
130 140 150 160 170 180
NQATQNAHIV LCHQSFYHNG VIYLVLEYMD RGSLADIIKQ VKTILEPYLA VLCKQVLEGL
190 200 210 220 230 240
LYLHHERHVI HRDIKPSNLL VNRKGEVKIT DFGVSAVLAS SMGQRDTFVG TYNYMAPERI
250 260 270 280 290 300
SGSSYDYKSD IWSLGLVILE CAIGRFPYIP SEGEGWLSFY ELLEAIVDQP PPSAPADQFS
310 320 330 340 350
PEFCAFISSC IQKDPAERMS ASELLNHPFI KKFEDKDLDL RILVESLEPP MNISE