P38650

PR
Gene name
Dync1h1 (Dhc1, Dnch1, Dnchc1, Dnec1, Dyhc, Map1c)
Protein name
Cytoplasmic dynein 1 heavy chain 1
Names
Cytoplasmic dynein heavy chain 1 , Dynein heavy chain, cytosolic , MAP 1C
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
rno:29489
EC number
3.1.4.11: Phosphoric diester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

240-830 (Dynein Tail) SS

Target domain

1899-3093 (Motor domain)

Relief mechanism

Partner binding

Assay

1319-1717 (Dynein heavy chain linker) SS

Target domain

1899-3093 (Motor domain)

Relief mechanism

Partner binding

Assay

1866-4219 (Motor domain) SS

Target domain

1866-4219 (Motor domain in other dynein-1)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for P38650

Entry ID Method Resolution Chain Position Source

No variants for P38650

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P38650

1 associated diseases with P38650

Without disease ID

6 regional properties for P38650

Type Name Position InterPro Accession
domain Protein kinase domain 510 - 786 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 511 - 777 IPR001245
conserved_site Tyrosine-protein kinase, receptor class II, conserved site 670 - 678 IPR002011
active_site Tyrosine-protein kinase, active site 639 - 651 IPR008266
binding_site Protein kinase, ATP binding site 516 - 544 IPR017441
domain Tyrosine-protein kinase, catalytic domain 510 - 777 IPR020635

Functions

Description
EC Number 3.1.4.11 Phosphoric diester hydrolases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

14 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
axon cytoplasm Any cytoplasm that is part of a axon.
axonemal dynein complex A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.
cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic dynein complex Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains.
cytoplasmic microtubule Any microtubule in the cytoplasm of a cell.
dynein complex Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity.
filopodium Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
manchette A tubular array of microtubules that extends from the perinuclear ring surrounding the spermatid nucleus to the flagellar axoneme. The manchette may also contain F-actin filaments.
microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction
dynein intermediate chain binding Binding to an intermediate chain of the dynein complex.
dynein light intermediate chain binding Binding to a light intermediate chain of the dynein complex.
minus-end-directed microtubule motor activity A motor activity that generates movement along a microtubule toward the minus end, driven by ATP hydrolysis.

16 GO annotations of biological process

Name Definition
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
cellular response to 3,3',5-triiodo-L-thyronine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3,3',5-triiodo-L-thyronine stimulus.
cellular response to nerve growth factor stimulus A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus.
cytoplasmic microtubule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell.
establishment of spindle localization The directed movement of the spindle to a specific location in the cell.
mitotic spindle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
nuclear migration The directed movement of the nucleus to a specific location within a cell.
P-body assembly The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body.
positive regulation of cold-induced thermogenesis Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
positive regulation of intracellular transport Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells.
positive regulation of spindle assembly Any process that activates or increases the frequency, rate or extent of spindle assembly.
regulation of metaphase plate congression Any process that modulates the rate, frequency, or extent of metaphase plate congression, the alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle.
regulation of mitotic spindle organization Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
retrograde axonal transport The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons.
spermatid development The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.
stress granule assembly The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P36022 DYN1 Dynein heavy chain, cytoplasmic Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) EV
P37276 Dhc64C Dynein heavy chain, cytoplasmic Drosophila melanogaster (Fruit fly) SS
Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 Homo sapiens (Human) EV
Q9JHU4 Dync1h1 Cytoplasmic dynein 1 heavy chain 1 Mus musculus (Mouse) SS
Q19020 dhc-1 Dynein heavy chain, cytoplasmic Caenorhabditis elegans SS
10 20 30 40 50 60
MTESAIDDQR FNLTKELQRH SCRDQGKITQ KDDALDFISY SSFQSSFNTD QKSANNGSTV
70 80 90 100 110 120
RRSIRSIFRR AAELPRVHMG PLTYSHGINE LVNKKLRKDC DLSTLCRVLQ RGIRMIRMTR
130 140 150 160 170 180
RRRKFYEFKL INNNGQIIWK DGSKYLELDS VKDIRIGDTA STYQEEVDPK RLRSDSKLWI
190 200 210 220 230 240
AIIYKVSNKL KALHVVALNE LDFNTFLSCI CGLVKLRREL MESILLPDNS QFARIHWQIT
250 260 270 280 290 300
VSEKEEDEKK DTLSFADVKK LCDKFHIYVS TGQLLEFFQL ADINHNGLLN YFEFEKFIKI
310 320 330 340 350 360
LKNRKEVNMI WSKFTKPPHS HLSFENFFQF LITEQHEQVD RQTAWSYFIK YREPTQLTMG
370 380 390 400 410 420
QDGFTKFLKE QPYLVEVKEE LYSKPLNHYF IASSHNTYLL GKQIAETPSV EGYIQVLQQG
430 440 450 460 470 480
CRCVEIDIWD GENGPVVCHG FLTSAIPLKT VIRVIKKYAF ITSPYPLIIS LEINCNKDNQ
490 500 510 520 530 540
KLASLIMREV LAEQLYFVGT RTDKLPSPRE LKHKILLKSK KTSEATRGLS VNEPFPSSFS
550 560 570 580 590 600
SSYESANEQE LRMKDDSTNS SSATNSSSMQ RIKRIGLKKH ADIINDVSNI SGIHGIKFRN
610 620 630 640 650 660
FSLPESKTIA HCFSLNERKV EYMIKDKHLK LSLDKHNRRY LMRVYPHVLR YKSSNFNPIP
670 680 690 700 710 720
FWKAGVQMVA TNWQTNDIGQ QLNLAMFQIL DHQPDGSFKS GYVLKPKKLL PVVTKAKMIP
730 740 750 760 770 780
LIYEHFENGS DPVTVKIRIL STQLLPRLND TSPSRNNTNS FVKVEFHTDD EPTMPISIDK
790 800 810 820 830 840
GTRISATEAS TKSSQGNGFN PIWDAEVSIT LKDTDLTFIK FMVISEETQI ASVCLKLNYL
850 860
RMGYRHIPLF NMEGEQYIFC TLFIHTQIL