AiPD: Autoinhibited Protein Database

Q9H900

Gene name	ZWILCH
Protein name	Protein zwilch homolog
Names	hZwilch
Species	Homo sapiens (Human)
KEGG Pathway	hsa:55055
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

41-123 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

41-123 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

3 structures for Q9H900

Entry ID	Method	Resolution	Chain	Position	Source
3IF8	X-ray	255 A			PDB
7QPG	EM	390 A	B/C	1-591	PDB
AF-Q9H900-F1	Predicted				AlphaFoldDB

486 variants for Q9H900

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs748258443 CA7625100	2	W>S		No	ClinGen ExAC gnomAD
rs200469112 CA392946978	3	E>*		No	ClinGen 1000Genomes gnomAD
CA271659489 rs200469112	3	E>Q		No	ClinGen 1000Genomes gnomAD
rs147940200 CA392946985	4	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs147940200 CA392946984	4	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA271659499 rs1000289102	5	L>M		No	ClinGen TOPMed
CA392946990 rs1248491175	5	L>P		No	ClinGen gnomAD
rs1000289102 CA271659502	5	L>V		No	ClinGen TOPMed
rs1595898697 CA392946993	6	N>D		No	ClinGen Ensembl
rs749004706 CA7625103	6	N>K		No	ClinGen ExAC gnomAD
CA392947005 rs770824598	7	C>*		No	ClinGen ExAC gnomAD
rs770824598 CA392947006	7	C>W		No	ClinGen ExAC gnomAD
rs1430596952 CA392947002	7	C>Y		No	ClinGen TOPMed
CA392947011 rs1567037197	8	A>V		No	ClinGen Ensembl
rs773862299 CA7625105	9	A>V		No	ClinGen ExAC TOPMed gnomAD
CA392947022 rs775096510	10	E>D		No	ClinGen ExAC gnomAD
CA7625106 rs199667793	10	E>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1257357493 CA392947019	10	E>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA7625107 rs199667793	10	E>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA392947027 rs112076842	11	D>A		No	ClinGen ExAC gnomAD
rs1443495622 CA392947030	11	D>E		No	ClinGen TOPMed gnomAD
CA7625109 rs112076842	11	D>G		No	ClinGen ExAC gnomAD
rs1480435947 CA392947024	11	D>N		No	ClinGen TOPMed
rs112076842 CA392947028	11	D>V		No	ClinGen ExAC gnomAD
CA7625110 rs532664071	12	F>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1488345153 CA392947039	13	Y>D		No	ClinGen TOPMed
CA7625111 rs773838464	13	Y>F		No	ClinGen ExAC gnomAD
rs1488345153 CA392947040	13	Y>H		No	ClinGen TOPMed
CA7625113 rs763216070	15	R>C		No	ClinGen ExAC TOPMed gnomAD
CA392947058 rs1402728256	16	L>F		No	ClinGen gnomAD
rs1454361865 CA392947059	16	L>H		No	ClinGen gnomAD
rs11551829 CA7625116 RCV000967369	17	L>F		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1229270492 CA392947069	18	Q>*		No	ClinGen gnomAD
rs756172113 CA7625138	19	K>I		No	ClinGen ExAC gnomAD
TCGA novel rs764175147 CA392947101	20	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen ExAC TOPMed gnomAD
rs753867134 CA7625141	23	E>G		No	ClinGen ExAC gnomAD
CA392947128 rs1345185228	24	K>Q		No	ClinGen gnomAD
CA392947130 rs1454343463	24	K>R		No	ClinGen gnomAD
CA7625142 rs757174315	28	R>C		No	ClinGen ExAC TOPMed gnomAD
CA7625143 rs201349152	28	R>H		No	ClinGen ExAC TOPMed gnomAD
rs757174315 CA271661139	28	R>S		No	ClinGen ExAC TOPMed gnomAD
rs1457567280 CA392947190	33	L>F		No	ClinGen gnomAD
rs781710931 CA7625144	34	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs781710931 CA7625145	34	Y>S		No	ClinGen ExAC TOPMed gnomAD
CA7625169 rs150492797	36	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs770707895 CA271666282	36	A>T		No	ClinGen Ensembl
rs769256442 CA7625170	42	L>M		No	ClinGen ExAC TOPMed
rs779376855 CA392947274	43	I>M		No	ClinGen ExAC TOPMed gnomAD
CA392947305 rs1595905134	48	P>T		No	ClinGen Ensembl
CA7625172 rs746314737	50	P>L		No	ClinGen ExAC gnomAD
CA271666348 rs79460599	56	N>H		No	ClinGen TOPMed
CA7625173 rs375123343	58	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA7625174 rs560116307	59	D>G		No	ClinGen 1000Genomes ExAC
CA7625175 rs199928523	60	I>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA271666385 rs1030115240	62	F>L		No	ClinGen TOPMed gnomAD
CA392947408 rs1368592053	63	I>L		No	ClinGen TOPMed
CA392947413 rs1595905165	63	I>M		No	ClinGen Ensembl
CA392947418 rs1161005601	64	V>A		No	ClinGen gnomAD
CA7625177 rs545769609	65	E>K		No	ClinGen 1000Genomes ExAC gnomAD
rs761946015 CA7625178	66	K>E		No	ClinGen ExAC TOPMed gnomAD
rs765175164 CA7625179	67	V>G		No	ClinGen ExAC TOPMed
CA392947434 rs1231015389	67	V>M		No	ClinGen gnomAD
rs201043795 CA271667146	68	P>S		No	ClinGen 1000Genomes
rs1567041877 CA392947466	70	E>G		No	ClinGen Ensembl
rs763758500 CA7625208	71	K>R		No	ClinGen ExAC gnomAD
CA7625209 rs753323083	72	E>K		No	ClinGen ExAC gnomAD
CA392947481 rs1450075330	72	E>V		No	ClinGen gnomAD
CA7625210 rs138124415	73	E>D		No	ClinGen ESP ExAC
CA392947484 rs1595906194	73	E>K		No	ClinGen Ensembl
CA7625211 rs780533919	74	T>R		No	ClinGen ExAC gnomAD
rs747525295 CA7625212	75	S>G		No	ClinGen ExAC gnomAD
rs1432277934 CA392947500	75	S>I		No	ClinGen gnomAD
rs755514803 CA7625214	76	H>L		No	ClinGen ExAC gnomAD
CA7625213 rs755514803	76	H>R		No	ClinGen ExAC gnomAD
CA7625215 rs748568573	80	L>F		No	ClinGen ExAC gnomAD
rs748568573 CA392947533	80	L>I		No	ClinGen ExAC gnomAD
CA271667181 rs78541569	83	E>K		No	ClinGen Ensembl
CA7625217 rs773612685	84	E>G		No	ClinGen ExAC gnomAD
CA271667192 rs78136359	85	T>P		No	ClinGen Ensembl
CA392947570 rs1203346760	86	A>T		No	ClinGen gnomAD
CA392947580 rs1191032059	87	I>T		No	ClinGen gnomAD
CA392947576 rs1448827965	87	I>V		No	ClinGen gnomAD
TCGA novel	90	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1481023113 CA392947612	92	T>A		No	ClinGen gnomAD
rs1202200344 CA392947616	92	T>I		No	ClinGen TOPMed gnomAD
CA392947625 rs1385158908	94	E>A		No	ClinGen gnomAD
CA7625221 rs140891720	94	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7625223 rs775094191	96	V>A		No	ClinGen ExAC gnomAD
rs972007369 CA271667208	98	P>Q		No	ClinGen Ensembl
CA271667210 rs918564740	101	L>F		No	ClinGen Ensembl
CA392947667 rs1203399721	101	L>V		No	ClinGen gnomAD
CA392947673 rs1285108796	102	P>A		No	ClinGen gnomAD
rs1454401251 CA392947687	104	G>E		No	ClinGen TOPMed
CA7625227 rs369115862	106	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs767909467 CA7625252	108	Q>P		No	ClinGen ExAC gnomAD
CA392947749 rs1164890927	112	L>F		No	ClinGen gnomAD
rs202072879 CA7625254	112	L>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA392947753 rs1308595097	113	Y>H		No	ClinGen TOPMed
rs1308595097 CA392947752	113	Y>N		No	ClinGen TOPMed
rs778218941 CA7625255	114	T>I		No	ClinGen ExAC TOPMed gnomAD
rs754283537 CA7625256	115	M>V		No	ClinGen ExAC gnomAD
CA7625257 rs757502358	116	A>T		No	ClinGen ExAC gnomAD
rs1389452465 CA392947790	118	N>S		No	ClinGen gnomAD
CA392947797 rs1330952547	119	P>H		No	ClinGen gnomAD
rs867984141 CA271668822	121	M>V		No	ClinGen gnomAD
CA7625259 rs745904715	122	T>I		No	ClinGen ExAC TOPMed gnomAD
CA7625260 rs142081992	123	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA7625261 rs779840465	124	L>V		No	ClinGen ExAC gnomAD
CA271668833 rs755971304	126	I>F		No	ClinGen TOPMed
CA7625262 rs746888973	128	L>Q		No	ClinGen ExAC gnomAD
CA392947861 rs1195522096	129	P>A		No	ClinGen gnomAD
CA7625263 rs768613564	130	V>L		No	ClinGen ExAC gnomAD
rs374330243 CA271668842	131	T>A		No	ClinGen ESP TOPMed gnomAD
CA392947877 rs1595908930	132	A>S		No	ClinGen Ensembl
CA392947880 rs1185027150	132	A>V		No	ClinGen gnomAD
CA392947884 rs1387563715	133	L>F		No	ClinGen TOPMed
TCGA novel	134	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7625264 rs776362439	135	P>L		No	ClinGen ExAC gnomAD
CA392947895 rs1240773017	135	P>S		No	ClinGen gnomAD
CA7625265 rs761646838	136	L>F		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	137	W>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7625266 rs769299514	137	W>R		No	ClinGen ExAC gnomAD
rs772987880 CA7625267	138	V>A		No	ClinGen ExAC gnomAD
CA392947918 rs1273284041	139	R>G		No	ClinGen TOPMed gnomAD
CA392947940 rs1406509853	142	S>R		No	ClinGen gnomAD
CA7625268 rs762359569	143	S>A		No	ClinGen ExAC gnomAD
CA392947952 rs1308432173	143	S>L		No	ClinGen TOPMed gnomAD
CA7625269 rs765860207	144	D>V		No	ClinGen ExAC gnomAD
rs1054728926 CA271668867	145	P>S		No	ClinGen Ensembl
rs751121477 CA7625270	146	E>K		No	ClinGen ExAC gnomAD
CA271668877 rs201760221	147	G>D		No	ClinGen Ensembl
CA271668881 rs878946349	150	W>*		No	ClinGen Ensembl
CA392948007 rs1306229541	152	G>A		No	ClinGen gnomAD
rs761221374 CA7625271	152	G>R		No	ClinGen ExAC gnomAD
CA271668889 rs1009890095	153	A>T		No	ClinGen TOPMed gnomAD
TCGA novel	153	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754228504 CA7625273	156	I>M		No	ClinGen ExAC gnomAD
rs757675757 CA7625274	158	T>A		No	ClinGen ExAC gnomAD
CA7625275 rs150058435	158	T>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	159	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1315597891 CA392948080	163	T>I		No	ClinGen TOPMed
rs377460492 CA271668899	164	G>R		No	ClinGen gnomAD
TCGA novel	166	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1426619239 CA392948105	167	L>F		No	ClinGen gnomAD
rs758560847 CA7625277	168	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA392948107 rs1376951491	168	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA7625278 rs139933771	172	C>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA392948176 rs1303558329	176	K>E		No	ClinGen TOPMed
COSM1374194 rs749056249 CA7625308	176	K>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	177	N>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs770682122 CA392948193	178	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs1308673130 CA392948189	178	Y>D		No	ClinGen TOPMed gnomAD
rs770682122 CA7625309	178	Y>F		No	ClinGen ExAC TOPMed gnomAD
CA392948190 rs1308673130	178	Y>H		No	ClinGen TOPMed gnomAD
CA7625310 rs141331169	179	S>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA392948201 rs1490806006	180	V>I		No	ClinGen gnomAD
CA7625311 rs542002882	182	L>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs997421812 CA271670017	183	E>A		No	ClinGen Ensembl
rs1405994563 CA392948315	187	N>I		No	ClinGen gnomAD
rs139005365 CA271670023	188	L>I		No	ClinGen ESP
CA392948344 rs762313169	189	H>L		No	ClinGen ExAC TOPMed gnomAD
CA392948347 rs762313169	189	H>P		No	ClinGen ExAC TOPMed gnomAD
rs765693494 CA7625315	189	H>Q		No	ClinGen ExAC gnomAD
CA7625314 rs762313169	189	H>R		No	ClinGen ExAC TOPMed gnomAD
rs1387661743 CA392948355	190	K>E		No	ClinGen gnomAD
CA271670029 rs970947648	191	K>*		No	ClinGen TOPMed
CA392948371 rs970947648	191	K>E		No	ClinGen TOPMed
COSM194152 CA271670034 rs562042882	192	R>I	large_intestine endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes TOPMed
CA7625316 rs773605455	193	H>D		No	ClinGen ExAC gnomAD
CA392948403 rs773605455	193	H>Y		No	ClinGen ExAC gnomAD
rs1323466852 CA392948425	194	H>Y		No	ClinGen TOPMed gnomAD
rs1567044192 CA392948443	195	L>V		No	ClinGen Ensembl
CA7625317 rs763269039	196	S>F		No	ClinGen ExAC TOPMed gnomAD
rs147137740 CA7625318	197	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA392948557 rs1208469584	198	V>L		No	ClinGen Ensembl
CA7625336 rs773660084	202	G>D		No	ClinGen ExAC gnomAD
CA392948613 rs771232194	203	F>C		No	ClinGen ExAC gnomAD
rs35789979 CA7625337	203	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA7625338 rs771232194	203	F>S		No	ClinGen ExAC gnomAD
rs1255976721 CA392948618	204	A>P		No	ClinGen gnomAD
rs530554607 CA271670462	204	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA392948632 rs1399583525	206	Y>H		No	ClinGen gnomAD
rs774706792 CA7625339	207	E>D		No	ClinGen ExAC gnomAD
CA392948699 rs1461264742	210	K>E		No	ClinGen TOPMed
rs759717506 CA7625340	213	A>T		No	ClinGen ExAC TOPMed gnomAD
rs753738429 CA7625342	214	L>W		No	ClinGen ExAC TOPMed gnomAD
CA7625343 rs760707213	215	D>G		No	ClinGen ExAC gnomAD
CA392948819 rs140389510	217	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs140389510 CA7625345	217	T>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs764084085 CA7625344	217	T>S		No	ClinGen ExAC gnomAD
CA7625346 rs144338336	219	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1332883695 CA392948891	222	Q>R		No	ClinGen gnomAD
rs1192703016 CA392948912	223	T>I		No	ClinGen TOPMed
rs750272676 CA7625348	224	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1276207942 CA392948925	224	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs373537835 CA7625350	226	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA392948947 rs373537835	226	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs373537835 CA7625351	226	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA271670518 rs375560885	228	D>H		No	ClinGen ESP gnomAD
rs375560885 CA392948980	228	D>Y		No	ClinGen ESP gnomAD
CA7625352 rs768109565	230	S>F		No	ClinGen ExAC TOPMed gnomAD
CA271670520 rs768109565	230	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1049852497 CA271670531	236	E>G		No	ClinGen Ensembl
rs1220514236 CA392949132	237	I>V		No	ClinGen TOPMed
CA392949159 rs780768540	239	Q>E		No	ClinGen ExAC gnomAD
rs780768540 CA7625353	239	Q>K		No	ClinGen ExAC gnomAD
rs1595910561 CA392949186	240	I>T		No	ClinGen Ensembl
rs147926670 CA7625354	241	P>L		No	ClinGen ESP ExAC gnomAD
CA7625356 rs373567295	243	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA7625358 rs772304279	246	T>I		No	ClinGen ExAC TOPMed gnomAD
CA7625359 rs775638387	247	A>V		No	ClinGen ExAC gnomAD
CA7625360 rs760792008	248	T>A		No	ClinGen ExAC TOPMed gnomAD
CA7625361 rs760792008	248	T>P		No	ClinGen ExAC TOPMed gnomAD
rs768953341 CA7625379	250	N>H		No	ClinGen ExAC
CA392950333 rs1329805864	252	K>E		No	ClinGen TOPMed gnomAD
rs776800933 CA7625380	254	E>K		No	ClinGen ExAC gnomAD
CA7625382 rs765263706	256	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1360224806 CA392950375	258	P>S		No	ClinGen gnomAD
rs773342931 CA7625383	260	G>R		No	ClinGen ExAC TOPMed gnomAD
rs773342931 CA392950386	260	G>S		No	ClinGen ExAC TOPMed gnomAD
rs762997367 COSM1189048 CA7625386	266	Y>C	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs762997367 CA7625387	266	Y>F		No	ClinGen ExAC TOPMed gnomAD
CA392950436 rs1458847278	267	R>K		No	ClinGen TOPMed gnomAD
CA7625388 rs374127628	268	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA
rs1287226102 CA392950453	270	K>E		No	ClinGen TOPMed
rs149603367 CA7625409	277	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA392950515 rs1447954222	277	D>G		No	ClinGen TOPMed
CA392950520 rs1476713715	278	G>R		No	ClinGen gnomAD
rs976784805 CA271677162	279	L>V		No	ClinGen TOPMed gnomAD
CA7625411 rs151117810	281	T>S		No	ClinGen ESP ExAC
rs1467678616 CA392950547	282	G>D		No	ClinGen TOPMed gnomAD
rs867421865 CA271677180	283	V>I		No	ClinGen TOPMed
CA392950553 rs1301214002	284	T>P		No	ClinGen gnomAD
rs540165637 CA7625412	287	L>F		No	ClinGen 1000Genomes ExAC gnomAD
rs760330951 CA7625413	287	L>P		No	ClinGen ExAC gnomAD
rs753376082 CA7625415	288	E>K		No	ClinGen ExAC TOPMed gnomAD
rs753376082 CA392950580	288	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs893791223 CA271677234	289	P>H		No	ClinGen TOPMed gnomAD
rs1211758111 CA392950594	290	L>P		No	ClinGen gnomAD
CA271677243 rs758780844	290	L>V		No	ClinGen ExAC TOPMed gnomAD
CA392950600 rs1253787311	291	E>A		No	ClinGen gnomAD
CA392950605 rs1482634396	292	A>P		No	ClinGen gnomAD
CA392950608 rs1205712304	292	A>V		No	ClinGen gnomAD
rs1471776682 CA392950613	293	K>T		No	ClinGen TOPMed
CA7625417 rs780660190	295	A>P		No	ClinGen ExAC gnomAD
rs751838837 CA7625418	295	A>V		No	ClinGen ExAC gnomAD
CA7625419 rs755429665	296	V>I		No	ClinGen ExAC TOPMed gnomAD
CA392950628 rs755429665	296	V>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	297	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781700715 CA7625420	304	N>S		No	ClinGen ExAC gnomAD
CA392950719 rs1456098079	307	N>T		No	ClinGen TOPMed
CA392950740 rs1249016417	310	D>G		No	ClinGen TOPMed
CA7625432 rs760277549	310	D>Y		No	ClinGen ExAC gnomAD
rs1296095809 CA392950758	313	G>S		No	ClinGen TOPMed gnomAD
CA7625433 rs763756621	315	S>F		No	ClinGen ExAC gnomAD
CA7625434 rs753263940	316	T>A		No	ClinGen ExAC TOPMed gnomAD
rs761426640 CA7625436	317	K>E		No	ClinGen ExAC gnomAD
rs766790030 CA7625437	319	D>G		No	ClinGen ExAC TOPMed gnomAD
rs746390455	319	D>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA392950863 rs201666467	321	E>D		No	ClinGen 1000Genomes ExAC gnomAD
rs781656882 CA7625440	323	E>D		No	ClinGen ExAC TOPMed gnomAD
CA392951150 rs1424875098	325	L>W		No	ClinGen gnomAD
rs1478970466 CA392951156	326	K>T		No	ClinGen gnomAD
CA271678204 rs898547516	327	H>R		No	ClinGen Ensembl
TCGA novel	328	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	330	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7625465 rs760072320	330	A>V		No	ClinGen ExAC gnomAD
rs1397617761 CA392951188	331	A>S		No	ClinGen gnomAD
rs1464677452 CA392951192	331	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA7625469 rs140914823	333	D>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM470988 CA7625467 rs140914823	333	D>N	kidney [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA7625468 rs140914823	333	D>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7625470 rs376275071	334	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs372540184 CA7625471	334	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA392951206 rs372540184	334	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA7625473 rs150190821	335	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA7625472 rs150190821	335	S>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA392951213 rs780004451	336	V>F		No	ClinGen ExAC TOPMed gnomAD
COSM3764532 CA7625475 rs780004451	336	V>I	central_nervous_system haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA7625476 rs138838416	337	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA271678240 rs138838416	337	K>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7625478 rs776295095	338	R>C		No	ClinGen ExAC gnomAD
CA7625479 rs375472609	338	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA7625481 rs772759748	341	K>R		No	ClinGen ExAC TOPMed gnomAD
rs200970538 CA271678261	343	R>L		No	ClinGen ExAC TOPMed gnomAD
rs200970538 CA7625483	343	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA7625482 rs762594506	343	R>W		No	ClinGen ExAC gnomAD
VAR_038055 CA7625484 rs11071896	344	S>G		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
TCGA novel	349	A>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA271678269 rs991187640	350	E>K		No	ClinGen TOPMed
CA392951307 rs1466398327	351	Q>*		No	ClinGen TOPMed
CA7625487 rs764448800	351	Q>P		No	ClinGen ExAC TOPMed gnomAD
rs764448800 CA7625486	351	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA7625489 rs765425325	354	C>Y		No	ClinGen ExAC gnomAD
CA271678304 rs924984482	355	K>Q		No	ClinGen Ensembl
rs935016254 CA271678314	356	M>I		No	ClinGen Ensembl
CA392951341 rs1420986529	356	M>V		No	ClinGen TOPMed
rs750469731 CA7625490	357	S>I		No	ClinGen ExAC TOPMed gnomAD
rs750469731 CA7625491	357	S>N		No	ClinGen ExAC TOPMed gnomAD
CA7625508 rs750702366	359	S>N		No	ClinGen ExAC TOPMed gnomAD
CA392951393 rs1379189187	362	S>P		No	ClinGen gnomAD
rs145727647 CA7625511	366	L>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs754922653 CA7625512	368	K>E		No	ClinGen ExAC gnomAD
CA7625513 rs781034081	368	K>N		No	ClinGen ExAC TOPMed
rs1179364226 CA392951450	369	C>Y		No	ClinGen TOPMed
rs752534902 CA7625514	370	F>L		No	ClinGen ExAC gnomAD
rs138641813 CA7625515	371	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs750143404 CA271678771	372	L>W		No	ClinGen Ensembl
rs770735224 CA7625519	375	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA7625520 rs778515059	379	R>C		No	ClinGen ExAC gnomAD
CA7625521 rs781621042	379	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA392951579 rs778515059	379	R>S		No	ClinGen ExAC gnomAD
rs769173962 CA7625523	380	G>D		No	ClinGen ExAC gnomAD
rs769173962 CA7625522	380	G>V		No	ClinGen ExAC gnomAD
CA7625528 rs766638150	381	D>E		No	ClinGen ExAC gnomAD
CA7625526 rs769995701	381	D>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA7625525 rs769995701	381	D>N		No	ClinGen ExAC TOPMed gnomAD
CA7625527 rs139478630	381	D>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1341548508 CA392951618	382	I>M		No	ClinGen gnomAD
CA7625529 rs377218620	382	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA392951612 rs1477911009	382	I>V		No	ClinGen TOPMed gnomAD
CA7625532 rs752522290	385	W>*		No	ClinGen ExAC gnomAD
CA392952307 rs764172582	387	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs753652498 CA392952312	388	S>N		No	ClinGen ExAC gnomAD
CA7625553 rs753652498	388	S>T		No	ClinGen ExAC gnomAD
CA392952324 rs1378286043	390	S>G		No	ClinGen gnomAD
rs764969449 CA7625555	390	S>N		No	ClinGen ExAC gnomAD
rs559367350 CA7625557	392	S>N		No	ClinGen 1000Genomes
rs1595917669 CA392952352	394	L>I		No	ClinGen Ensembl
rs779383305 CA7625560	394	L>P		No	ClinGen ExAC gnomAD
CA7625561 rs746579713	395	S>N		No	ClinGen ExAC gnomAD
rs778321438 CA7625563	398	I>V		No	ClinGen ExAC gnomAD
rs749642463 CA7625565	399	H>D		No	ClinGen ExAC TOPMed gnomAD
rs749642463 CA7625564	399	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs774786799 CA392952389	400	Q>*		No	ClinGen ExAC gnomAD
CA7625566 rs774786799	400	Q>K		No	ClinGen ExAC gnomAD
CA392952390 rs1428549222	400	Q>P		No	ClinGen TOPMed
CA271680819 rs760608164	401	S>F		No	ClinGen Ensembl
rs1370483807 CA392952413	403	H>L		No	ClinGen TOPMed
CA392952422 rs1343391890	405	T>P		No	ClinGen gnomAD
rs182841691 CA7625568	406	M>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA392952429 rs1278143222	406	M>V		No	ClinGen gnomAD
TCGA novel	407	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1435257961 CA392952441	407	D>V		No	ClinGen TOPMed
CA392952445 rs1217215661	408	T>A		No	ClinGen gnomAD
CA7625571 rs764121179	412	S>I		No	ClinGen ExAC gnomAD
CA271680828 rs999990031	413	G>R		No	ClinGen TOPMed gnomAD
CA7625572 rs376356151	413	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA7625573 rs199947479	415	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA392952543 rs1482807396	417	V>I		No	ClinGen TOPMed
CA392952569 rs1420898172	418	Q>H		No	ClinGen gnomAD
rs1024749021 CA271680837	419	M>I		No	ClinGen TOPMed
CA7625574 rs765057462	419	M>K		No	ClinGen ExAC TOPMed gnomAD
rs750263110 CA7625575	422	E>*		No	ClinGen ExAC
CA7625576 rs757965380	423	I>V		No	ClinGen ExAC gnomAD
rs751028896 CA392952658	425	L>F		No	ClinGen ExAC TOPMed gnomAD
rs368758542 CA392952647	425	L>M		No	ClinGen TOPMed gnomAD
TCGA novel	426	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7625580 rs780697482	431	D>E		No	ClinGen ExAC TOPMed gnomAD
rs754280084 CA7625581	432	Y>C		No	ClinGen ExAC gnomAD
rs754280084 CA392952752	432	Y>S		No	ClinGen ExAC gnomAD
rs754079572 TCGA novel	437	I>H	Variant assessed as Somatic; impact. Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs772150723 CA7625586	437	I>K		No	ClinGen ExAC gnomAD
CA7625585 rs779094520 CA7625584	437	I>L		No	ClinGen ExAC TOPMed gnomAD
CA271680893 rs779094520	437	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1351234574 CA392952898	439	Q>*		No	ClinGen TOPMed
rs750746354 CA7625604	441	L>F		No	ClinGen ExAC gnomAD
CA7625605 rs144575461	442	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1270090383 CA392952954	443	S>C		No	ClinGen Ensembl
rs1435360983 CA392952949	443	S>P		No	ClinGen TOPMed gnomAD
CA392952966 rs1567049271	444	L>F		No	ClinGen Ensembl
CA7625607 rs747159932	446	H>P		No	ClinGen ExAC gnomAD
rs1360783054 CA392953162	448	E>K		No	ClinGen gnomAD
rs755220575 CA7625628	453	P>L		No	ClinGen ExAC TOPMed gnomAD
rs755220575 CA392953202	453	P>Q		No	ClinGen ExAC TOPMed gnomAD
CA7625629 rs368082642	454	S>L		No	ClinGen ESP ExAC gnomAD
CA392953213 rs1219848512	455	V>A		No	ClinGen gnomAD
rs756159007 CA392953218	456	D>A		No	ClinGen ExAC gnomAD
CA7625631 rs756159007	456	D>G		No	ClinGen ExAC gnomAD
CA392953226 rs1353771907	457	I>M		No	ClinGen gnomAD
CA7625633 rs749206771	457	I>T		No	ClinGen ExAC TOPMed gnomAD
rs777717814 CA7625632	457	I>V		No	ClinGen ExAC TOPMed gnomAD
CA7625634 rs770791665	460	Q>*		No	ClinGen ExAC gnomAD
rs770791665 CA271683174	460	Q>E		No	ClinGen ExAC gnomAD
CA7625635 rs200770623	463	R>H		No	ClinGen ExAC TOPMed gnomAD
rs745707724 CA7625636	464	V>D		No	ClinGen ExAC gnomAD
CA392953277 rs1474811865	465	Q>R		No	ClinGen gnomAD
rs1014235625 CA271683190	467	L>F		No	ClinGen Ensembl
rs771712554 CA7625637	469	H>L		No	ClinGen ExAC gnomAD
CA271683195 rs935241880	469	H>Y		No	ClinGen TOPMed
rs775184821 CA7625638	472	E>D		No	ClinGen ExAC TOPMed gnomAD
CA7625639 rs200409020	473	I>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs763594625 CA7625641	475	V>I		No	ClinGen ExAC TOPMed gnomAD
rs542360758 CA7625642	476	S>R		No	ClinGen 1000Genomes ExAC gnomAD
CA392953366 rs1326115738	478	M>I		No	ClinGen TOPMed gnomAD
CA7625643 rs763469678	480	F>L		No	ClinGen ExAC gnomAD
CA7625644 rs767043050	482	K>Q		No	ClinGen ExAC gnomAD
CA392953426 rs1368869314	485	H>Y		No	ClinGen TOPMed gnomAD
rs1234213243 CA392953440	486	E>K		No	ClinGen gnomAD
CA7625645 rs751967738	487	L>F		No	ClinGen ExAC gnomAD
rs755451520 CA7625646	488	L>F		No	ClinGen ExAC
rs752897918 CA7625649	489	F>S		No	ClinGen ExAC gnomAD
rs1316103607 CA392953524	491	L>S		No	ClinGen TOPMed
CA392953538 rs1203717295	492	T>K		No	ClinGen gnomAD
CA392953549 rs1233813750	493	Q>*		No	ClinGen TOPMed
CA7625659 rs768216135	494	I>N		No	ClinGen ExAC TOPMed gnomAD
CA392953615 rs1274596497	495	C>F		No	ClinGen gnomAD
CA271683954 rs549811304	496	I>V		No	ClinGen 1000Genomes
rs1212476412 CA392953630	497	K>N		No	ClinGen gnomAD
rs569962378 CA7625660	498	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
CA7625661 rs761296511	499	Y>C		No	ClinGen ExAC gnomAD
CA271683959 rs562397303	499	Y>H		No	ClinGen gnomAD
rs766979661 CA7625662	500	K>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	503	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs184225895 CA7625663	503	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1167404529 CA392953677	504	L>P		No	ClinGen TOPMed gnomAD
rs1567051184 CA392953679	505	D>N		No	ClinGen Ensembl
CA392953689 rs1461092672	506	E>*		No	ClinGen TOPMed gnomAD
rs1332182552 CA392953692	506	E>G		No	ClinGen gnomAD
rs1332182552 CA392953691	506	E>V		No	ClinGen gnomAD
CA392953708 rs1398705837	508	H>L		No	ClinGen gnomAD
CA392953707 rs1398705837	508	H>R		No	ClinGen gnomAD
CA271683975 rs890180796	509	I>T		No	ClinGen TOPMed gnomAD
rs753022831 CA7625666	509	I>V		No	ClinGen ExAC TOPMed gnomAD
CA271683981 rs140334767	511	Q>R		No	ClinGen ESP gnomAD
rs866791832 CA271683987	512	L>M		No	ClinGen Ensembl
CA392953733 rs1567051226	512	L>P		No	ClinGen Ensembl
rs1294778250 CA392953757	516	P>L		No	ClinGen gnomAD
CA392953761 rs1332276134	517	T>A		No	ClinGen gnomAD
CA7625667 rs760925092	517	T>S		No	ClinGen ExAC gnomAD
CA7625668 rs764259303	518	A>D		No	ClinGen ExAC gnomAD
rs753952884 CA7625669	519	V>I		No	ClinGen ExAC gnomAD
CA392953782 COSM1234851 rs1249677443	520	K>N	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA271684000 rs943083947	521	N>D		No	ClinGen gnomAD
rs778981545 CA7625671	523	Y>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1475034763 CA392953805	524	Q>E		No	ClinGen gnomAD
CA392954527 rs1420644455	525	S>R		No	ClinGen gnomAD
rs747760389 CA271686298	528	P>L		No	ClinGen ExAC TOPMed gnomAD
rs747760389 CA7625695	528	P>R		No	ClinGen ExAC TOPMed gnomAD
rs144273335 CA7625696	529	Q>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1294300632 CA392954571	531	W>*		No	ClinGen gnomAD
rs1380151587 CA392954565	531	W>R		No	ClinGen TOPMed gnomAD
CA7625697 rs373125098	533	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA7625699 rs75532475	535	I>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7625698 rs376057448	535	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1490672514 CA392954656	536	Y>*		No	ClinGen TOPMed
rs1246266999 CA392954643	536	Y>H		No	ClinGen TOPMed
rs888302102 CA271686322	537	S>G		No	ClinGen Ensembl
rs775924197 CA7625700	538	G>S		No	ClinGen ExAC gnomAD
TCGA novel	541	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1262239983 CA392954787	544	T>S		No	ClinGen gnomAD
TCGA novel	546	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7625702 rs139335459	546	W>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA7625703 rs201080159	547	Q>K		No	ClinGen 1000Genomes ExAC gnomAD
rs761976244 CA7625705	549	S>T		No	ClinGen ExAC gnomAD
rs1192333140 CA392954880	550	D>A		No	ClinGen gnomAD
CA271686376 rs1005454290	551	S>R		No	ClinGen TOPMed gnomAD
rs202040277 CA7625706	553	P>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs773245805 CA271686382	554	I>R		No	ClinGen ExAC TOPMed gnomAD
rs773245805 CA7625707	554	I>T		No	ClinGen ExAC TOPMed gnomAD
CA392954911 rs1323850605	554	I>V		No	ClinGen gnomAD
CA7625709 rs375608651	555	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA7625711 rs574259380	556	H>D		No	ClinGen 1000Genomes ExAC gnomAD
CA7625710 rs574259380	556	H>Y		No	ClinGen 1000Genomes ExAC gnomAD
rs767166759 CA7625712	557	L>P		No	ClinGen ExAC TOPMed gnomAD
rs752585176 CA7625713	558	N>D		No	ClinGen ExAC gnomAD
rs755794911 CA7625714	561	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1312603497 CA392955367	564	F>L		No	ClinGen TOPMed
CA7625734 rs372166697	565	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA392955395 rs1567055061	568	T>I		No	ClinGen Ensembl
CA7625737 rs149217755	569	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	570	N>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA271692824 rs942470933	571	G>D		No	ClinGen TOPMed gnomAD
CA7625740 rs547318979	571	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs770075683 CA7625741	573	L>V		No	ClinGen ExAC gnomAD
CA392955435 rs1216359366	575	E>A		No	ClinGen gnomAD
CA392955442 rs1270930238	576	R>K		No	ClinGen TOPMed gnomAD
CA392955443 rs1270930238	576	R>T		No	ClinGen TOPMed gnomAD
rs773597871 CA7625742	577	I>T		No	ClinGen ExAC TOPMed gnomAD
CA7625743 rs749420690	579	F>L		No	ClinGen ExAC gnomAD
rs759726067 CA7625746	582	M>I		No	ClinGen ExAC gnomAD
rs774261063 CA7625745	582	M>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA7625747 rs771886892	583	V>F		No	ClinGen ExAC gnomAD
CA392955489 rs771886892	583	V>I		No	ClinGen ExAC gnomAD
CA7625748 rs377164724	585	C>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs760696190 CA7625749	586	S>C		No	ClinGen ExAC gnomAD

No associated diseases with Q9H900

1 regional properties for Q9H900

Type	Name	Position	InterPro Accession
domain	Zinc finger, SWIM-type	139 - 176	IPR007527

Functions

		Description
EC Number
Subcellular Localization	Chromosome, centromere, kinetochore
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
kinetochore	A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
kinetochore microtubule	Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation.
RZZ complex	A kinetochore component required for both meiotic and mitotic spindle assembly checkpoints.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name	Definition
cell division	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
mitotic spindle assembly checkpoint signaling	A signal transduction process that contributes to a mitotic cell cycle spindle assembly checkpoint, that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.
protein localization to kinetochore	Any process in which a protein is transported to, or maintained at, the kinetochore.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8R060	Zwilch	Protein zwilch homolog	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MWERLNCAAE	DFYSRLLQKF	NEEKKGIRKD	PFLYEADVQV	QLISKGQPNP	LKNILNENDI
70	80	90	100	110	120
VFIVEKVPLE	KEETSHIEEL	QSEETAISDF	STGENVGPLA	LPVGKARQLI	GLYTMAHNPN
130	140	150	160	170	180
MTHLKINLPV	TALPPLWVRC	DSSDPEGTCW	LGAELITTNN	SITGIVLYVV	SCKADKNYSV
190	200	210	220	230	240
NLENLKNLHK	KRHHLSTVTS	KGFAQYELFK	SSALDDTITA	SQTAIALDIS	WSPVDEILQI
250	260	270	280	290	300
PPLSSTATLN	IKVESGEPRG	PLNHLYRELK	FLLVLADGLR	TGVTEWLEPL	EAKSAVELVQ
310	320	330	340	350	360
EFLNDLNKLD	GFGDSTKKDT	EVETLKHDTA	AVDRSVKRLF	KVRSDLDFAE	QLWCKMSSSV
370	380	390	400	410	420
ISYQDLVKCF	TLIIQSLQRG	DIQPWLHSGS	NSLLSKLIHQ	SYHGTMDTVS	LSGTIPVQML
430	440	450	460	470	480
LEIGLDKLKK	DYISFFIGQE	LASLNHLEYF	IAPSVDIQEQ	VYRVQKLHHI	LEILVSCMPF
490	500	510	520	530	540
IKSQHELLFS	LTQICIKYYK	QNPLDEQHIF	QLPVRPTAVK	NLYQSEKPQK	WRVEIYSGQK
550	560	570	580	590
KIKTVWQLSD	SSPIDHLNFH	KPDFSELTLN	GSLEERIFFT	NMVTCSQVHF	K