Q8R060

PR
Gene name
Zwilch
Protein name
Protein zwilch homolog
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:68014
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-124 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8R060

Entry ID Method Resolution Chain Position Source
AF-Q8R060-F1 Predicted AlphaFoldDB

No variants for Q8R060

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8R060

No associated diseases with Q8R060

No regional properties for Q8R060

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8R060

Functions

Description
EC Number
Subcellular Localization
  • Chromosome, centromere, kinetochore
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
kinetochore A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
RZZ complex A kinetochore component required for both meiotic and mitotic spindle assembly checkpoints.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
mitotic spindle assembly checkpoint signaling A signal transduction process that contributes to a mitotic cell cycle spindle assembly checkpoint, that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.
protein localization to kinetochore Any process in which a protein is transported to, or maintained at, the kinetochore.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9H900 ZWILCH Protein zwilch homolog Homo sapiens (Human) PR
10 20 30 40 50 60
MWSRMNRAAE EFYARLRQEF NEEKKGASKD PFIYEADVQV QLISKGQPSL LKTILNENDS
70 80 90 100 110 120
VFLVEKVVLE KEETSQVEEL QSEETAISDL SAGENIRPLA LPVGRARQLI GLYTMAHNPN
130 140 150 160 170 180
MTHLKIKQPV TALPPLWVRC DGSDPEGTCW LGAELITTND IIAGVILYVL TCKADKNYSE
190 200 210 220 230 240
DLENLKTSHK KRHHVSAVTA RGFAQYELFK SDDLDDTVAP SQTTVTLDLS WSPVDEMLQT
250 260 270 280 290 300
PPLSSTAALN IRVQSGESRG CLSHLHRELK FLLVLADGIR TGVTEWLEPL ETKSALEFVQ
310 320 330 340 350 360
EFLNDLNKLD EFDDSTKKDK QKEAVNHDAA AVVRSMLLTV RGDLDFAEQL WCRMSSSVVS
370 380 390 400 410 420
YQDLVKCFTL ILQSLQRGDI QPWLHSGSNS LLSKLIHQSY HGAMDSVPLS GTTPLQMLLE
430 440 450 460 470 480
IGLDKLKKDY ISFFVSQELA SLNHLEYFIS PSVSTQEQVC RVQKLHHILE ILVICMLFIK
490 500 510 520 530 540
PQHELLFSLT QSCIKYYKQN PLDEQHIFQL PVRPAAVKNL YQSEKPQKWR VELSNSQKRV
550 560 570 580
KTVWQLSDSS PVDHSSFHRP EFPELTLNGS LEERTAFVNM LTCSQVHFK