AiPD: Autoinhibited Protein Database

Q9H7P6

Gene name	MVB12B (C9orf28, FAM125B)
Protein name	Multivesicular body subunit 12B
Names	ESCRT-I complex subunit MVB12B, Protein FAM125B
Species	Homo sapiens (Human)
KEGG Pathway	hsa:89853
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

166-263 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

166-263 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q9H7P6

Entry ID	Method	Resolution	Chain	Position	Source
3TOW	X-ray	134 A	A	47-192	PDB
AF-Q9H7P6-F1	Predicted				AlphaFoldDB

210 variants for Q9H7P6

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1474523220 CA375157649	2	R>G		No	ClinGen TOPMed
rs1255103184 CA375157658	3	S>G		No	ClinGen TOPMed
rs757375558 CA5241862	3	S>N		No	ClinGen ExAC TOPMed gnomAD
CA375157689 rs1468077554	7	V>L		No	ClinGen TOPMed
CA375157710 rs1333470430	10	S>I		No	ClinGen gnomAD
CA375157717 rs1438800750	11	R>Q		No	ClinGen TOPMed gnomAD
CA200167288 rs966604473	12	D>A		No	ClinGen Ensembl
CA375157721 rs966604473	12	D>G		No	ClinGen Ensembl
CA375157718 rs1267086204	12	D>N		No	ClinGen TOPMed gnomAD
rs1046914720 CA200167290	13	P>R		No	ClinGen TOPMed
CA375157745 rs1196058568	16	P>Q		No	ClinGen gnomAD
CA375157742 rs1487459164	16	P>S		No	ClinGen gnomAD
rs1474884521 CA375157753	17	Q>P		No	ClinGen gnomAD
rs1474884521 CA375157751	17	Q>R		No	ClinGen gnomAD
CA200167291 rs928503847	18	P>L		No	ClinGen TOPMed gnomAD
rs1162858066 CA375157758	18	P>S		No	ClinGen gnomAD
CA375157784 rs1179050166	22	P>L		No	ClinGen TOPMed
CA375157794 rs1481027544	24	Q>R		No	ClinGen TOPMed
CA5241868 rs750581562	25	R>G		No	ClinGen ExAC gnomAD
rs1354286186 CA375157800	25	R>Q		No	ClinGen TOPMed gnomAD
CA200168653 rs865867922	29	Q>P		No	ClinGen Ensembl
TCGA novel	30	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA375157984 rs775267564	37	D>H		No	ClinGen ExAC gnomAD
rs775267564 CA5241879	37	D>N		No	ClinGen ExAC gnomAD
CA5241880 rs762592143	41	A>T		No	ClinGen ExAC gnomAD
rs1047398433 CA200168654	45	T>M		No	ClinGen TOPMed gnomAD
rs370526944 CA5241885	47	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA5241886 rs750528154	49	P>A		No	ClinGen ExAC gnomAD
CA200168655 rs981167020	51	T>M		No	ClinGen TOPMed
rs754094585 CA5241889	52	G>A		No	ClinGen ExAC TOPMed gnomAD
rs754094585 CA200168656	52	G>V		No	ClinGen ExAC TOPMed gnomAD
CA5241892 rs371651537	54	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA5241893 rs758869168	57	A>S		No	ClinGen ExAC gnomAD
rs1487674130 CA375158111	57	A>V		No	ClinGen TOPMed gnomAD
rs769355896 CA5241896	59	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs376223657 CA5241895	59	R>W		No	ClinGen ESP ExAC gnomAD
rs779537062 CA5241897	60	N>K		No	ClinGen ExAC TOPMed gnomAD
rs748995734 CA5241898	61	R>*		No	ClinGen ExAC gnomAD
CA5241899 rs768474662	63	P>L		No	ClinGen ExAC gnomAD
rs761769045 CA5241901	64	T>I		No	ClinGen ExAC TOPMed gnomAD
rs772123143 CA5241902	65	G>S		No	ClinGen ExAC TOPMed gnomAD
CA375158152 rs1200381628	65	G>V		No	ClinGen TOPMed
CA5241903 rs773214805	66	Y>C		No	ClinGen ExAC gnomAD
CA375158156 rs773214805	66	Y>S		No	ClinGen ExAC gnomAD
rs766510440 CA5241905	68	V>I	Variant assessed as Somatic; 4.62e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA375158168 rs766510440	68	V>L		No	ClinGen ExAC TOPMed gnomAD
rs1173371819 CA375158405	69	V>I		No	ClinGen gnomAD
CA200172818 rs199545552	70	A>T		No	ClinGen 1000Genomes gnomAD
CA5241933 rs753387548	72	T>S		No	ClinGen ExAC gnomAD
rs538080040 CA200172819	74	D>G		No	ClinGen Ensembl
rs1564299604 CA375158441	75	G>S		No	ClinGen Ensembl
rs369827319 CA200172820	76	V>M		No	ClinGen ESP gnomAD
CA5241935 rs778641944	79	D>E		No	ClinGen ExAC gnomAD
CA375158468 rs1220402815	79	D>N		No	ClinGen gnomAD
CA375158506 rs1207883676	84	G>S		No	ClinGen gnomAD
CA5241937 rs758218136	85	L>S		No	ClinGen ExAC gnomAD
rs1262576541 CA375158542	89	K>R		No	ClinGen gnomAD
CA5241939 rs746817932	90	V>I		No	ClinGen ExAC gnomAD
CA375158597 rs143952903	97	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA5241941 rs143952903	97	T>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs531823720 CA200172822	98	R>T		No	ClinGen gnomAD
CA5241942 rs376328919	99	S>*		No	ClinGen ExAC gnomAD
CA375158612 rs1490939928	100	F>C		No	ClinGen TOPMed
TCGA novel	101	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1239244783 CA375158697	110	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1219015533 CA375158728	114	M>I		No	ClinGen gnomAD
rs1351848910 CA375158723	114	M>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA200173390 rs7042337	117	I>M		No	ClinGen Ensembl
CA5241964 rs768910687	117	I>N		No	ClinGen ExAC gnomAD
rs749440278 CA5241963	117	I>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	121	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	121	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA375158785 rs1258960214	122	T>I		No	ClinGen gnomAD
rs1588129610 CA375158794	124	P>H		No	ClinGen Ensembl
rs954591059 CA200173391	125	V>L		No	ClinGen gnomAD
CA375158798 rs954591059	125	V>M		No	ClinGen gnomAD
rs761241798 CA5241969	127	F>Y		No	ClinGen ExAC
rs1366536187 CA375158821	128	I>M		No	ClinGen TOPMed
rs1158805714 CA375158827	129	P>R		No	ClinGen TOPMed gnomAD
CA5241971 rs142076731	130	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs759410517 CA5241973	133	T>M	Variant assessed as Somatic; 4.637e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA5241974 rs751172053	134	V>M		No	ClinGen ExAC gnomAD
rs1378788881 CA375158869	136	T>A		No	ClinGen gnomAD
rs757032890 CA5241975	137	Q>*		No	ClinGen ExAC gnomAD
rs757032890 CA375158875	137	Q>K		No	ClinGen ExAC gnomAD
CA375158933 rs1588134232	143	K>R		No	ClinGen Ensembl
rs1588134237 CA375158959	147	C>G		No	ClinGen Ensembl
CA5241991 rs751132994	148	I>N		No	ClinGen ExAC gnomAD
rs763539920 CA5241990	148	I>V		No	ClinGen ExAC TOPMed gnomAD
CA200173915 rs1046059	153	R>L		No	ClinGen ESP gnomAD
rs1046059 CA375159001	153	R>Q		No	ClinGen ESP gnomAD
CA375159000 rs1218578712	153	R>W		No	ClinGen gnomAD
rs1160633436 CA375159006	154	D>A		No	ClinGen gnomAD
CA5241992 rs762556242	156	T>M		No	ClinGen ExAC gnomAD
CA375159041 rs1265205569	159	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
TCGA novel	160	I>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5241995 rs755918627	163	I>V		No	ClinGen ExAC gnomAD
rs9696000 CA5241996	164	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs868665716 CA200173916	164	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1410440069 CA375159085	166	M>T		No	ClinGen gnomAD
rs778835257 CA5241999	168	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA5241998 rs755037370	168	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs748298929 CA5242000	169	T>A		No	ClinGen ExAC gnomAD
CA5242001 rs758687675	170	K>R		No	ClinGen ExAC gnomAD
CA375159107 rs758687675	170	K>T		No	ClinGen ExAC gnomAD
CA5242002 rs778196558	172	A>V		No	ClinGen ExAC gnomAD
CA5242003 rs747316940	173	P>L		No	ClinGen ExAC gnomAD
CA5242005 rs777234498	174	P>A		No	ClinGen ExAC gnomAD
rs1292132045 CA375159145	176	Y>C		No	ClinGen gnomAD
CA5242006 rs746380516	176	Y>H		No	ClinGen ExAC gnomAD
CA5242007 rs770377005	177	T>M		No	ClinGen ExAC TOPMed gnomAD
CA5242009 rs761447220	178	F>V		No	ClinGen ExAC gnomAD
CA375159162 rs1391738299	179	I>V		No	ClinGen TOPMed
rs1481912764 CA375159348	183	N>K		No	ClinGen gnomAD
rs372966231 CA200174271	184	S>T		No	ClinGen ESP TOPMed
CA5242031 rs766058718	188	W>C		No	ClinGen ExAC gnomAD
rs146439908 CA5242032	189	Y>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM1460043 rs1254051514 CA375159395	190	R>*	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA375159397 rs565843409	190	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5242033 rs565843409	190	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5242035 rs752681926	191	M>T		No	ClinGen ExAC gnomAD
CA5242034 rs765025626	191	M>V		No	ClinGen ExAC gnomAD
rs764287029 CA5242037	193	R>G		No	ClinGen ExAC gnomAD
CA375159425 rs1218173612	195	P>S		No	ClinGen gnomAD
TCGA novel	196	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA200174272 rs944299189	197	N>K		No	ClinGen Ensembl
rs1313905405 CA375159440	197	N>S		No	ClinGen gnomAD
TCGA novel	199	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA375159459 rs1173873310	200	S>T		No	ClinGen gnomAD
CA5242039 rs757552035	201	S>T		No	ClinGen ExAC gnomAD
rs1287355434 CA375159478	203	P>T		No	ClinGen TOPMed
rs750697603 CA5242041	205	T>A		No	ClinGen ExAC gnomAD
rs141017138 CA200174273	205	T>M		No	ClinGen ESP TOPMed gnomAD
CA200174274 rs992314382	206	P>S		No	ClinGen TOPMed
rs1296155210 CA375159503	207	S>F		No	ClinGen TOPMed
rs1226095209 CA375159533	212	A>T		No	ClinGen TOPMed
rs918208813 CA200174275	214	T>A		No	ClinGen TOPMed gnomAD
rs749819404 CA5242044	216	A>P		No	ClinGen ExAC TOPMed gnomAD
rs769200378 CA5242045	216	A>V		No	ClinGen ExAC gnomAD
CA5242046 rs200109520	218	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA375159577 rs200109520	218	N>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	218	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA375159590 rs1400193932	219	L>F		No	ClinGen gnomAD
CA5242048 rs374523885	221	R>K		No	ClinGen ESP ExAC gnomAD
rs1297568643 CA375158189	222	H>Y		No	ClinGen TOPMed
CA5242068 rs571157881	223	I>V		No	ClinGen 1000Genomes ExAC gnomAD
rs267602133 CA200177425	224	S>F		No	ClinGen TOPMed
CA5242069 rs769378924	225	L>V		No	ClinGen ExAC gnomAD
rs768659812 CA5242072	232	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA375158253 rs1490893027	233	G>S		No	ClinGen gnomAD
CA5242073 rs774438553	233	G>V		No	ClinGen ExAC gnomAD
CA5242074 rs761762511	235	N>S		No	ClinGen ExAC gnomAD
rs375748135 CA200177426	236	S>N		No	ClinGen ESP
TCGA novel	236	S>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA375158279 rs1477147176	237	T>A		No	ClinGen gnomAD
CA375158285 rs1374009612	238	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs767658868 CA5242075	238	R>W		No	ClinGen ExAC gnomAD
rs144763623 CA5242076	239	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA375158295 rs1246613225	240	D>N		No	ClinGen TOPMed gnomAD
CA200177427 rs1017712032	241	Y>C		No	ClinGen TOPMed
CA375158308 rs1490977058	242	E>Q		No	ClinGen TOPMed
CA375158334 rs1291158072	245	H>Y		No	ClinGen TOPMed
rs1357992930 CA375158362	249	Y>H		No	ClinGen gnomAD
rs1354609063 CA375158374	250	A>G		No	ClinGen TOPMed
rs1282083425 CA375158378	251	I>T		No	ClinGen TOPMed
rs754187798 CA5242079	251	I>V		No	ClinGen ExAC gnomAD
COSM1701739 rs1215491682 CA375159194	254	M>I	skin [Cosmic]	No	ClinGen cosmic curated gnomAD
rs376094935 CA5242110	254	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs748974816 CA5242111	257	V>L		No	ClinGen ExAC
CA5242113 rs778819852	260	M>I		No	ClinGen ExAC TOPMed gnomAD
CA375159235 rs1178379740	260	M>T		No	ClinGen gnomAD
rs1256409466 CA375159231	260	M>V		No	ClinGen TOPMed
CA5242115 rs772034708	263	E>Q		No	ClinGen ExAC gnomAD
rs370464876 CA5242139	272	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs746940748 CA5242138	272	M>V		No	ClinGen ExAC gnomAD
TCGA novel	274	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA375159607 rs1205634054	275	F>V		No	ClinGen gnomAD
CA200184446 rs1007603235	276	D>G		No	ClinGen Ensembl
rs775582985 CA5242143	280	I>V		No	ClinGen ExAC TOPMed
rs1207064930 CA375159661	281	T>P		No	ClinGen TOPMed
rs763339136 CA5242144	282	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1268902363 CA375159679	283	K>N		No	ClinGen TOPMed gnomAD
CA5242145 rs768929152	285	L>V		No	ClinGen ExAC gnomAD
CA5242147 rs762380210	286	A>E		No	ClinGen ExAC TOPMed gnomAD
rs1163803026 CA375159711	289	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA200186806 rs568988744	293	E>*		No	ClinGen 1000Genomes TOPMed gnomAD
CA375160283 rs1281782939	293	E>D		No	ClinGen gnomAD
rs568988744 CA200186805	293	E>K		No	ClinGen 1000Genomes TOPMed gnomAD
rs1285680556 CA375160292	294	Y>C		No	ClinGen gnomAD
rs772651109 CA5242169	297	R>C		No	ClinGen ExAC TOPMed gnomAD
rs772651109 CA200186807	297	R>G		No	ClinGen ExAC TOPMed gnomAD
rs760736690 CA200186808	297	R>H		No	ClinGen TOPMed gnomAD
rs1462526680 CA375160348	298	T>I		No	ClinGen TOPMed gnomAD
CA375160370 rs1195637299	300	Q>*		No	ClinGen TOPMed
rs1244044886 CA375160376	300	Q>H		No	ClinGen gnomAD
rs1337872176 CA375160396 COSM3432863	302	A>T	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA375160405 rs1175567748	303	A>D		No	ClinGen gnomAD
rs759075392 CA375160413	304	A>S		No	ClinGen ExAC gnomAD
CA5242171 rs759075392	304	A>T		No	ClinGen ExAC gnomAD
rs762477987 CA5242174	308	P>S		No	ClinGen ExAC gnomAD
CA375160465 rs1334819047	309	S>G		No	ClinGen gnomAD
CA375160487 rs1281381731	310	P>L		No	ClinGen TOPMed
rs987416431 CA200186811	311	T>I		No	ClinGen Ensembl
rs1280815752 CA375160501	312	R>G		No	ClinGen gnomAD
rs1373364905 CA375160519	313	C>Y		No	ClinGen gnomAD
CA375160528 rs1218108054	314	Q>*		No	ClinGen gnomAD
CA375160531 rs1459776483	314	Q>R		No	ClinGen TOPMed gnomAD
rs763869651 CA5242175	316	I>T		No	ClinGen ExAC gnomAD
rs778783906 CA200186812	317	P>L		No	ClinGen TOPMed gnomAD
CA375160579 rs1257125115	318	Q>K		No	ClinGen TOPMed gnomAD

No associated diseases with Q9H7P6

2 regional properties for Q9H7P6

Type	Name	Position	InterPro Accession
domain	UMA domain	254 - 303	IPR023340
domain	MABP domain	47 - 193	IPR023341

Functions

		Description
EC Number
Subcellular Localization	Endosome Late endosome membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

10 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
early endosome	A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
endosome membrane	The lipid bilayer surrounding an endosome.
ESCRT I complex	An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
late endosome	A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
late endosome membrane	The lipid bilayer surrounding a late endosome.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
vesicle	Any small, fluid-filled, spherical organelle enclosed by membrane.

1 GO annotations of molecular function

Name	Definition
lipid binding	Binding to a lipid.

8 GO annotations of biological process

Name	Definition
membrane fission	A process that is carried out at the cellular level which results in the separation of a single continuous membrane into two membranes.
multivesicular body assembly	The aggregation, arrangement and bonding together of a set of components to form a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.
protein transport	The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	The process of directing proteins towards the vacuole that contributes to protein catabolism via the multivesicular body (MVB) pathway.
regulation of epidermal growth factor receptor signaling pathway	Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation.
viral budding	A viral process by which enveloped viruses acquire a host-derived membrane enriched in viral proteins to form their external envelope. The process starts when nucleocapsids, assembled or in the process of being built, induce formation of a membrane curvature in the host plasma or organelle membrane and wrap up in the forming bud. The process ends when the bud is eventually pinched off by membrane scission to release the enveloped particle into the lumenal or extracellular space.
virus maturation	The refolding and structural rearrangements of virion parts to transition from the intermediate virion to the more mature virion. Maturation usually involves proteolysis events and changes in the folding of the virion proteins. Can occur inside the host cell or after release.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q6KAU4	Mvb12b	Multivesicular body subunit 12B	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MRSCFCVRRS	RDPPPPQPPP	PPPQRGTDQS	TMPEVKDLSE	ALPETSMDPI	TGVGVVASRN
70	80	90	100	110	120
RAPTGYDVVA	QTADGVDADL	WKDGLFKSKV	TRYLCFTRSF	SKENSHLGNV	LVDMKLIDIK
130	140	150	160	170	180
DTLPVGFIPI	QETVDTQEVA	FRKKRLCIKF	IPRDSTEAAI	CDIRIMGRTK	QAPPQYTFIG
190	200	210	220	230	240
ELNSMGIWYR	MGRVPRNHDS	SQPTTPSQSS	AASTPAPNLP	RHISLTLPAT	FRGRNSTRTD
250	260	270	280	290	300
YEYQHSNLYA	ISAMDGVPFM	ISEKFSCVPE	SMQPFDLLGI	TIKSLAEIEK	EYEYSFRTEQ
310
SAAARLPPSP	TRCQQIPQS