Q6KAU4
Gene name |
Mvb12b (Fam125b) |
Protein name |
Multivesicular body subunit 12B |
Names |
ESCRT-I complex subunit MVB12B, Protein FAM125B |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:72543 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6KAU4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6KAU4-F1 | Predicted | AlphaFoldDB |
19 variants for Q6KAU4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388543227 | 38 | E>* | No | EVA | |
| rs3388548694 | 40 | L>M | No | EVA | |
| rs3388543220 | 42 | E>Q | No | EVA | |
| rs3388547742 | 58 | N>Y | No | EVA | |
| rs3388549581 | 60 | A>T | No | EVA | |
| rs3388550253 | 60 | A>V | No | EVA | |
| rs3391460905 | 95 | T>S | No | EVA | |
| rs3388547723 | 102 | N>S | No | EVA | |
| rs3391460907 | 148 | F>L | No | EVA | |
| rs3388549559 | 158 | I>F | No | EVA | |
| rs3388540066 | 171 | P>S | No | EVA | |
| rs3388550182 | 173 | Q>R | No | EVA | |
| rs224767061 | 175 | T>S | No | EVA | |
| rs3388543859 | 186 | W>L | No | EVA | |
| rs3388545968 | 206 | Q>R | No | EVA | |
| rs3388543849 | 224 | T>S | No | EVA | |
| rs3388549289 | 258 | M>K | No | EVA | |
| rs3388549558 | 297 | E>Q | No | EVA | |
| rs262818546 | 314 | I>M | No | EVA |
No associated diseases with Q6KAU4
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| early endosome | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. |
| ESCRT I complex | An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes. |
| late endosome | A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. |
| late endosome membrane | The lipid bilayer surrounding a late endosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| vesicle | Any small, fluid-filled, spherical organelle enclosed by membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| lipid binding | Binding to a lipid. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| regulation of epidermal growth factor receptor signaling pathway | Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity. |
| viral budding | A viral process by which enveloped viruses acquire a host-derived membrane enriched in viral proteins to form their external envelope. The process starts when nucleocapsids, assembled or in the process of being built, induce formation of a membrane curvature in the host plasma or organelle membrane and wrap up in the forming bud. The process ends when the bud is eventually pinched off by membrane scission to release the enveloped particle into the lumenal or extracellular space. |
| virus maturation | The refolding and structural rearrangements of virion parts to transition from the intermediate virion to the more mature virion. Maturation usually involves proteolysis events and changes in the folding of the virion proteins. Can occur inside the host cell or after release. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9H7P6 | MVB12B | Multivesicular body subunit 12B | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRSCFCVRRS | RDPPPPQPPP | PQRGTDQATM | PEVKELSEAL | PETPMDPITG | VGVVASRNRA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PTGYDVVAQT | ADGVDADLWK | DGLFKSKVTR | YLCFTRSFSK | ENSHLGNVLV | DMKLIDVKDT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LPVGFIPIQE | TVDTQEVVFR | KKRLCIKFIP | RDSTEAAICD | IRIMGRTKQA | PPQYTFIGEL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NSMGIWYRMG | RVPRNHDSSQ | PTTPSQSSAS | STPAPNLPRH | ISLTLPATFR | GRNNTSTDYE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YQLSNLYAIS | AMDGVPFMIS | EKFSCIPESM | QPFDLLGITI | KSLAEIEKEY | EYSFRTEQSA |
| 310 | |||||
| AARLPPSPTR | CQQIPQS |