AiPD: Autoinhibited Protein Database

Gene name	LKHA4 (At5g13520, T6I14_50)
Protein name	Leucine aminopeptidase
Names	Epoxide hydrolase, Leukotriene A-4 hydrolase homolog, LTA-4 hydrolase
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT5G13520
EC number	3.3.2.10: Ether hydrolases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

33-108 (Predicted disordered autoinhibitory region) PR

33-108 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9FY49-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
tmp_5_4344495_A_T	26	L>H	No	1000Genomes
tmp_5_4344397_C_A	59	A>S	No	1000Genomes
ENSVATH06963164	64	P>S	No	1000Genomes
ENSVATH06963163	68	E>K	No	1000Genomes
tmp_5_4344361_G_C	71	P>A	No	1000Genomes
tmp_5_4344280_T_G	98	I>L	No	1000Genomes
tmp_5_4344115_C_A	153	V>F	No	1000Genomes
tmp_5_4344076_C_A	166	A>S	No	1000Genomes
ENSVATH06963162	174	A>P	No	1000Genomes
ENSVATH00620476	184	A>T	No	1000Genomes
ENSVATH14017948	187	L>P	No	1000Genomes
tmp_5_4343991_C_T	194	G>D	No	1000Genomes
ENSVATH03053638	210	P>L	No	1000Genomes
tmp_5_4343923_C_T	217	V>I	No	1000Genomes
tmp_5_4343847_T_C	242	D>G	No	1000Genomes
ENSVATH06963161	243	A>E	No	1000Genomes
tmp_5_4343698_G_T,A	292	L>M	No	1000Genomes
tmp_5_4343447_A_T	334	F>Y	No	1000Genomes
tmp_5_4343382_T_C	356	I>V	No	1000Genomes
ENSVATH06963157	387	D>N	No	1000Genomes
ENSVATH06963156	404	V>A	No	1000Genomes
ENSVATH10732221	430	K>N	No	1000Genomes
ENSVATH06963150	436	T>I	No	1000Genomes
ENSVATH06963149	443	A>V	No	1000Genomes
ENSVATH00620473	454	L>I	No	1000Genomes
tmp_5_4342983_C_T	461	V>I	No	1000Genomes
ENSVATH10732218	534	D>N	No	1000Genomes
ENSVATH10732217	551	R>I	No	1000Genomes
tmp_5_4342307_T_C	554	H>R	No	1000Genomes
ENSVATH00620469	583	T>S	No	1000Genomes
tmp_5_4342183_T_A	595	E>D	No	1000Genomes
ENSVATH10732216	597	R>Q	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Peptidase M1, membrane alanine aminopeptidase	257 - 443	IPR014782
domain	Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal	473 - 612	IPR015211
domain	Aminopeptidase N-like, N-terminal domain	19 - 168	IPR045357

		Description
EC Number	3.3.2.10	Ether hydrolases
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Name	Definition
epoxide hydrolase activity	Catalysis of the reaction: an epoxide + H2O = a glycol.
metallopeptidase activity	Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
zinc ion binding	Binding to a zinc ion (Zn).

Name	Definition
leukotriene biosynthetic process	The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.
proteolysis	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8N6M6	AOPEP	Aminopeptidase O	Homo sapiens (Human)	PR
Q84TA3	LKHA4	Leucine aminopeptidase	Oryza sativa subsp japonica (Rice)	PR