Q84TA3

PR
Gene name
LKHA4 (Os03g0819100, LOC_Os03g60460, OJ1754_E06.9, OsJ_13129)
Protein name
Leucine aminopeptidase
Names
Epoxide hydrolase, Leukotriene A-4 hydrolase homolog, LTA-4 hydrolase
Species
Oryza sativa subsp japonica (Rice)
KEGG Pathway
osa:4334583
EC number
3.3.2.10: Ether hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-214 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q84TA3

Entry ID Method Resolution Chain Position Source
AF-Q84TA3-F1 Predicted AlphaFoldDB

No variants for Q84TA3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q84TA3

No associated diseases with Q84TA3

3 regional properties for Q84TA3

Type Name Position InterPro Accession
domain Peptidase M1, membrane alanine aminopeptidase 248 - 440 IPR014782
domain Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal 469 - 607 IPR015211
domain Aminopeptidase N-like, N-terminal domain 23 - 167 IPR045357

Functions

Description
EC Number 3.3.2.10 Ether hydrolases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
epoxide hydrolase activity Catalysis of the reaction: an epoxide + H2O = a glycol.
metallopeptidase activity Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
zinc ion binding Binding to a zinc ion (Zn).

2 GO annotations of biological process

Name Definition
leukotriene biosynthetic process The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8N6M6 AOPEP Aminopeptidase O Homo sapiens (Human) PR
Q9FY49 LKHA4 Leucine aminopeptidase Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MPPVDPHSYT DGDHPVTAKA ALAFYLDFAA STIHASALLT LSAPHSGDLL LDTRALAVHS
70 80 90 100 110 120
ASTASGPPSP IPFSLADAAD PVLGSALTLT LPPDTTSFLL TFSTSPSASA LQWLSPPQTA
130 140 150 160 170 180
SSLPFVFSQC QSIHARSVFP CHDTPAARIT FDLLLNVPTQ LSAVAAARHV SRRDPLPSDH
190 200 210 220 230 240
RGACDDALWC APGRIVEEFQ MEQSVPPYLF AFAAGGIGFR DLGPRTRVYA EGGDKVLDEA
250 260 270 280 290 300
AREFAGVEEM VKVGESLFGP YEWERFDLLV LPPSFPYGGM ENPRMVFLTP TVIKGDAAGA
310 320 330 340 350 360
QVVAHELAHS WTGNLITNKT NEDFWLNEGF TTYAERRIVE VVQGEERAAL NMGIGWRGLN
370 380 390 400 410 420
RMMERFKDNM EYTKLKPKMA GIDPDDVYSE VPYEKGFQFL WRIERQIGRP AFDEFLKNYI
430 440 450 460 470 480
STFKFKSIDT ETFLEFLKTN VPGIENQIDL QLWIEGTGIP PDAMEPESAI YKKICSLAAE
490 500 510 520 530 540
FKSGKLPSED EVADWSGQEW ELYLENLPTD VEASQVTALD ERYKLSESCD YEVKVAFLQL
550 560 570 580 590 600
AIPTGCRCYF NEVEKCLKQV GRMKYLRPLY SSLARCSGEE KMLAHRIFSE AHEFYHPIAR
610
SVAESILSKH G