AiPD: Autoinhibited Protein Database

Gene name	DIT2-1 (DIT2, At5g64290, MSJ1.13)
Protein name	Dicarboxylate transporter 2.1, chloroplastic
Names	AtpDCT1, Glutamate/malate translocator
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT5G64290
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-124 (Predicted disordered autoinhibitory region) PR

1-124 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9FMF7-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
tmp_5_25716539_G_T	35	T>N	No	1000Genomes
ENSVATH12925755	35	T>P	No	1000Genomes
ENSVATH00750827	62	I>T	No	1000Genomes
tmp_5_25716415_G_T	76	N>K	No	1000Genomes
ENSVATH07477120	84	S>F	No	1000Genomes
tmp_5_25716375_A_C	90	S>A	No	1000Genomes
tmp_5_25716372_G_A	91	P>S	No	1000Genomes
tmp_5_25716174_C_T	157	V>I	No	1000Genomes
ENSVATH14647706	162	S>P	No	1000Genomes
ENSVATH03473172	256	S>F	No	1000Genomes
tmp_5_25715877_A_G	256	S>P	No	1000Genomes
tmp_5_25715413_T_A	317	I>F	No	1000Genomes
tmp_5_25715146_C_G	377	E>D	No	1000Genomes
tmp_5_25715148_C_G	377	E>Q	No	1000Genomes
tmp_5_25715087_A_T	397	L>Q	No	1000Genomes
tmp_5_25714992_T_C	429	T>A	No	1000Genomes
ENSVATH00750806	437	M>I	No	1000Genomes
tmp_5_25714910_A_C	456	F>C	No	1000Genomes
tmp_5_25714763_T_C	505	N>S	No	1000Genomes
ENSVATH07477110	555	F>Y	No	1000Genomes
ENSVATH12925690	559	F>C	No	1000Genomes

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9FMF7

		Description
EC Number
Subcellular Localization	Plastid, chloroplast inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
chloroplast	A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
chloroplast envelope	The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
chloroplast inner membrane	The inner, i.e. lumen-facing, lipid bilayer of the chloroplast envelope; also faces the chloroplast stroma.
chloroplast thylakoid	Sac-like membranous structures (cisternae) in a chloroplast combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. An example of this component is found in Arabidopsis thaliana.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plastid	Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.

Name	Definition
L-glutamate transmembrane transporter activity	Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid.
malate transmembrane transporter activity	Enables the transfer of malate from one side of a membrane to the other. Malate is a chiral hydroxydicarboxylic acid, hydroxybutanedioic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle.
oxaloacetate transmembrane transporter activity	Enables the transfer of oxaloacetate, the anion of oxobutanedioic acid, from one side of a membrane to the other.

Name	Definition
ammonia assimilation cycle	The pathway by which ammonia is processed and incorporated into a cell. In an energy-rich (glucose-containing), nitrogen-poor environment, glutamine synthetase and glutamate synthase form an ammonia assimilatory cycle, in which ammonia is incorporated into L-glutamate to form L-glutamine, which then combines with alpha-ketoglutarate to regenerate L-glutamate. This ATP-dependent cycle is essential for nitrogen-limited growth and for steady-state growth with some sources of nitrogen.
L-glutamate transmembrane transport	The directed movement of L-glutamate across a membrane.
malate transmembrane transport	A process in which a malate ion is transported across a membrane.
oxaloacetate transport	The directed movement of oxaloacetate, the anion of oxobutanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
response to nematode	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a nematode.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9FMF8	DIT2-2	Dicarboxylate transporter 2.2, chloroplastic	Arabidopsis thaliana (Mouse-ear cress)	PR