Q9FIJ0

PR
Gene name
RBOHD
Protein name
Respiratory burst oxidase homolog protein D
Names
NADPH oxidase RBOHD, AtRBOHD
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G47910
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-183 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9FIJ0

Entry ID Method Resolution Chain Position Source
AF-Q9FIJ0-F1 Predicted AlphaFoldDB

27 variants for Q9FIJ0

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH07365268 14 L>F No 1000Genomes
ENSVATH07365270 48 A>T No 1000Genomes
tmp_5_19397753_G_A 57 D>N No 1000Genomes
ENSVATH00717852 64 N>S No 1000Genomes
ENSVATH00717853 87 S>A No 1000Genomes
tmp_5_19397879_G_A 99 G>S No 1000Genomes
tmp_5_19397930_C_A 116 L>I No 1000Genomes
ENSVATH03384086 123 T>N No 1000Genomes
tmp_5_19398045_C_G 154 A>G No 1000Genomes
ENSVATH14607780 159 D>A No 1000Genomes
tmp_5_19398153_A_G 190 D>G No 1000Genomes
ENSVATH07365277 199 L>V No 1000Genomes
tmp_5_19398376_G_A 234 G>S No 1000Genomes
ENSVATH12614154 342 L>F No 1000Genomes
ENSVATH03384107 349 K>N No 1000Genomes
ENSVATH03384108 356 S>R No 1000Genomes
ENSVATH00717865 360 V>L No 1000Genomes
tmp_5_19399934_C_A 427 L>I No 1000Genomes
tmp_5_19400051_A_G 466 I>V No 1000Genomes
ENSVATH07365318 524 V>L No 1000Genomes
tmp_5_19400235_C_T 527 A>V No 1000Genomes
tmp_5_19400350_C_G 565 I>M No 1000Genomes
ENSVATH00717874 572 I>V No 1000Genomes
tmp_5_19400977_G_A 693 E>K No 1000Genomes
ENSVATH14607803 735 K>N No 1000Genomes
tmp_5_19401109_G_A 737 D>N No 1000Genomes
ENSVATH03384117 892 M>I No 1000Genomes

No associated diseases with Q9FIJ0

3 regional properties for Q9FIJ0

Type Name Position InterPro Accession
domain Protein kinase domain 197 - 525 IPR000719
active_site Serine/threonine-protein kinase, active site 318 - 330 IPR008271
binding_site Protein kinase, ATP binding site 203 - 226 IPR017441

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.

4 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
ferric-chelate reductase activity Catalysis of the reaction: 2 Fe3+-siderophore + electron donor -> 2 Fe3+-siderophore + electron acceptor.
NAD(P)H oxidase H2O2-forming activity Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide.
peroxidase activity Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O.

8 GO annotations of biological process

Name Definition
carbohydrate homeostasis A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell.
cellular response to hypoxia Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
defense response to fungus Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.
negative regulation of programmed cell death Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.
osmosensory signaling pathway The series of molecular signals initiated in response to osmotic change.
reactive oxygen species metabolic process The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
response to heat Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
response to wounding Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q96PH1 NOX5 NADPH oxidase 5 Homo sapiens (Human) EV
Q948U0 RBOHA Respiratory burst oxidase homolog protein A Solanum tuberosum (Potato) PR
Q948T9 RBOHB Respiratory burst oxidase homolog protein B Solanum tuberosum (Potato) PR
Q2HXK9 RBOHD Respiratory burst oxidase homolog protein D Solanum tuberosum (Potato) PR
Q5ZAJ0 RBOHB Respiratory burst oxidase homolog protein B Oryza sativa subsp japonica (Rice) PR
O48538 RBOHF Respiratory burst oxidase homolog protein F Arabidopsis thaliana (Mouse-ear cress) PR
P92949 CDC5 Ferric reduction oxidase 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q8W110 FRO4 Ferric reduction oxidase 4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FJD6 RBOHH Putative respiratory burst oxidase homolog protein H Arabidopsis thaliana (Mouse-ear cress) PR
Q9SUT8 RBOHI Probable respiratory burst oxidase homolog protein I Arabidopsis thaliana (Mouse-ear cress) PR
F4I4K7 FRO3 Ferric reduction oxidase 3, mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
O81211 RBOHE Respiratory burst oxidase homolog protein E Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MKMRRGNSSN DHELGILRGA NSDTNSDTES IASDRGAFSG PLGRPKRASK KNARFADDLP
70 80 90 100 110 120
KRSNSVAGGR GDDDEYVEIT LDIRDDSVAV HSVQQAAGGG GHLEDPELAL LTKKTLESSL
130 140 150 160 170 180
NNTTSLSFFR STSSRIKNAS RELRRVFSRR PSPAVRRFDR TSSAAIHALK GLKFIATKTA
190 200 210 220 230 240
AWPAVDQRFD KLSADSNGLL LSAKFWECLG MNKESKDFAD QLFRALARRN NVSGDAITKE
250 260 270 280 290 300
QLRIFWEQIS DESFDAKLQV FFDMVDKDED GRVTEEEVAE IISLSASANK LSNIQKQAKE
310 320 330 340 350 360
YAALIMEELD PDNAGFIMIE NLEMLLLQAP NQSVRMGDSR ILSQMLSQKL RPAKESNPLV
370 380 390 400 410 420
RWSEKIKYFI LDNWQRLWIM MLWLGICGGL FTYKFIQYKN KAAYGVMGYC VCVAKGGAET
430 440 450 460 470 480
LKFNMALILL PVCRNTITWL RNKTKLGTVV PFDDSLNFHK VIASGIVVGV LLHAGAHLTC
490 500 510 520 530 540
DFPRLIAADE DTYEPMEKYF GDQPTSYWWF VKGVEGWTGI VMVVLMAIAF TLATPWFRRN
550 560 570 580 590 600
KLNLPNFLKK LTGFNAFWYT HHLFIIVYAL LIVHGIKLYL TKIWYQKTTW MYLAVPILLY
610 620 630 640 650 660
ASERLLRAFR SSIKPVKMIK VAVYPGNVLS LHMTKPQGFK YKSGQFMLVN CRAVSPFEWH
670 680 690 700 710 720
PFSITSAPGD DYLSVHIRTL GDWTRKLRTV FSEVCKPPTA GKSGLLRADG GDGNLPFPKV
730 740 750 760 770 780
LIDGPYGAPA QDYKKYDVVL LVGLGIGATP MISILKDIIN NMKGPDRDSD IENNNSNNNS
790 800 810 820 830 840
KGFKTRKAYF YWVTREQGSF EWFKGIMDEI SELDEEGIIE LHNYCTSVYE EGDARVALIA
850 860 870 880 890 900
MLQSLQHAKN GVDVVSGTRV KSHFAKPNWR QVYKKIAVQH PGKRIGVFYC GMPGMIKELK
910 920
NLALDFSRKT TTKFDFHKEN F