F4I4K7

PR
Gene name
FRO3 (FROHC, At1g23020, F19G10.4)
Protein name
Ferric reduction oxidase 3, mitochondrial
Names
AtFRO3, Ferric-chelate reductase 3
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G23020
EC number
1.16.1.7: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

503-584 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for F4I4K7

Entry ID Method Resolution Chain Position Source
AF-F4I4K7-F1 Predicted AlphaFoldDB

104 variants for F4I4K7

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_1_8153526_G_T 2 A>E No 1000Genomes
tmp_1_8153497_C_G 12 G>R No 1000Genomes
ENSVATH01091070 13 N>S No 1000Genomes
ENSVATH04627372 16 F>S No 1000Genomes
tmp_1_8153485_A_C 16 F>V No 1000Genomes
ENSVATH01091069 19 I>L No 1000Genomes
ENSVATH04627371 20 I>T No 1000Genomes
ENSVATH01091068 20 I>V No 1000Genomes
ENSVATH04627370 21 R>K No 1000Genomes
ENSVATH11842849 22 K>N No 1000Genomes
tmp_1_8153320_T_G 36 N>T No 1000Genomes
ENSVATH00038878 44 V>L No 1000Genomes
ENSVATH01091061 73 L>V No 1000Genomes
ENSVATH11842848 79 F>L No 1000Genomes
tmp_1_8152995_T_G 108 K>T No 1000Genomes
ENSVATH01091056 116 N>S No 1000Genomes
ENSVATH01091049 119 M>V No 1000Genomes
ENSVATH01091048 121 R>M No 1000Genomes
ENSVATH01091047 125 D>E No 1000Genomes
ENSVATH00038877 126 K>N No 1000Genomes
ENSVATH11842746 144 T>A No 1000Genomes
tmp_1_8152784_T_G 147 E>A No 1000Genomes
ENSVATH01091046 154 F>L No 1000Genomes
tmp_1_8152719_T_C 169 T>A No 1000Genomes
ENSVATH00038876 181 D>N No 1000Genomes
ENSVATH00038872 191 D>E No 1000Genomes
tmp_1_8152248_G_A 192 S>L No 1000Genomes
ENSVATH13949008 196 R>G No 1000Genomes
ENSVATH04627344 198 G>A No 1000Genomes
ENSVATH04627343 200 T>I No 1000Genomes
tmp_1_8152204_A_G 207 F>L No 1000Genomes
ENSVATH01091011 213 A>P No 1000Genomes
tmp_1_8152169_C_A 218 L>F No 1000Genomes
tmp_1_8152158_A_G 222 V>A No 1000Genomes
ENSVATH04627341 224 L>V No 1000Genomes
ENSVATH00038870 243 L>F No 1000Genomes
ENSVATH04627340 250 C>S No 1000Genomes
tmp_1_8152065_A_C 253 I>S No 1000Genomes
ENSVATH04627336 271 G>C No 1000Genomes
ENSVATH00038866 271 G>D No 1000Genomes
tmp_1_8151783_C_A 278 E>D No 1000Genomes
tmp_1_8151739_G_A 293 P>L No 1000Genomes
tmp_1_8151729_T_G 296 R>S No 1000Genomes
ENSVATH01090992 300 F>Y No 1000Genomes
tmp_1_8151683_C_T 312 V>I No 1000Genomes
ENSVATH04627335 330 F>Y No 1000Genomes
ENSVATH00038864 337 M>I No 1000Genomes
tmp_1_8151602_C_T 339 D>N No 1000Genomes
ENSVATH04627334 360 P>S No 1000Genomes
ENSVATH01090990 361 C>S No 1000Genomes
ENSVATH00038862 367 N>T No 1000Genomes
ENSVATH04627332 371 N>H No 1000Genomes
ENSVATH00038861 375 M>T No 1000Genomes
ENSVATH01090983 377 S>C No 1000Genomes
tmp_1_8151401_G_T 378 P>Q No 1000Genomes
tmp_1_8151326_C_G 403 S>T No 1000Genomes
ENSVATH04627329 411 S>I No 1000Genomes
ENSVATH04627328 417 Q>L No 1000Genomes
ENSVATH01090979 422 S>T No 1000Genomes
ENSVATH01090978 425 H>Y No 1000Genomes
ENSVATH01090977 426 H>Q No 1000Genomes
ENSVATH01090976 430 S>C No 1000Genomes
tmp_1_8151242_G_A 431 S>F No 1000Genomes
ENSVATH00038858 432 N>T No 1000Genomes
tmp_1_8151235_C_A 433 Q>H No 1000Genomes
ENSVATH01090975 435 D>E No 1000Genomes
tmp_1_8151221_G_C 438 A>G No 1000Genomes
tmp_1_8151219_C_A 439 V>F No 1000Genomes
ENSVATH00038857 446 G>V No 1000Genomes
ENSVATH04627326 448 A>T No 1000Genomes
ENSVATH01090974 454 R>G No 1000Genomes
ENSVATH00038855 478 L>I No 1000Genomes
ENSVATH00038854 481 S>N No 1000Genomes
ENSVATH11841711 485 A>T No 1000Genomes
ENSVATH01090970 488 T>I No 1000Genomes
tmp_1_8150966_A_C 493 L>V No 1000Genomes
ENSVATH04627320 494 I>L No 1000Genomes
ENSVATH00038852 499 N>T No 1000Genomes
tmp_1_8150912_G_C 511 P>A No 1000Genomes
ENSVATH01090966 520 I>V No 1000Genomes
ENSVATH04627319 533 V>L No 1000Genomes
ENSVATH11841709 538 M>K No 1000Genomes
ENSVATH04627317 576 M>I No 1000Genomes
ENSVATH11841708 584 I>N No 1000Genomes
ENSVATH01090963 599 E>K No 1000Genomes
ENSVATH01090961 605 T>K No 1000Genomes
tmp_1_8150587_G_C 619 A>G No 1000Genomes
tmp_1_8150573_C_T 624 A>T No 1000Genomes
tmp_1_8150553_C_A 630 K>N No 1000Genomes
ENSVATH01090959 631 S>N No 1000Genomes
ENSVATH01090958 633 F>C No 1000Genomes
ENSVATH01090958 633 F>Y No 1000Genomes
ENSVATH01090955 636 L>* No 1000Genomes
ENSVATH01090956 636 L>I No 1000Genomes
tmp_1_8150527_T_A 639 N>I No 1000Genomes
tmp_1_8150521_T_C 641 D>G No 1000Genomes
ENSVATH04627312 650 S>C No 1000Genomes
ENSVATH00038847 651 S>T No 1000Genomes
tmp_1_8150483_G_A 654 Q>* No 1000Genomes
ENSVATH04627310 669 N>Y No 1000Genomes
tmp_1_8150432_T_C 671 N>D No 1000Genomes
tmp_1_8150307_C_A 678 K>N No 1000Genomes
tmp_1_8150278_C_T 688 G>D No 1000Genomes
ENSVATH01090951 716 N>S No 1000Genomes

No associated diseases with F4I4K7

4 regional properties for F4I4K7

Type Name Position InterPro Accession
domain FAD-binding 8 349 - 449 IPR013112
domain Ferric reductase, NAD binding domain 455 - 701 IPR013121
domain Ferric reductase transmembrane component-like domain 198 - 318 IPR013130
domain FAD-binding domain, ferredoxin reductase-type 346 - 451 IPR017927

Functions

Description
EC Number 1.16.1.7 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Mitochondrion membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial membrane Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
ferric-chelate reductase (NADH) activity Catalysis of the reaction: 2 Fe3+-siderophore + NAD(+) + H(+) -> 2 Fe2+-siderophore + NADH.
ferric-chelate reductase activity Catalysis of the reaction: 2 Fe3+-siderophore + electron donor -> 2 Fe3+-siderophore + electron acceptor.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
ion transport The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q96PH1 NOX5 NADPH oxidase 5 Homo sapiens (Human) EV
Q948U0 RBOHA Respiratory burst oxidase homolog protein A Solanum tuberosum (Potato) PR
Q948T9 RBOHB Respiratory burst oxidase homolog protein B Solanum tuberosum (Potato) PR
Q5ZAJ0 RBOHB Respiratory burst oxidase homolog protein B Oryza sativa subsp japonica (Rice) PR
O48538 RBOHF Respiratory burst oxidase homolog protein F Arabidopsis thaliana (Mouse-ear cress) PR
O81211 RBOHE Respiratory burst oxidase homolog protein E Arabidopsis thaliana (Mouse-ear cress) PR
P92949 CDC5 Ferric reduction oxidase 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q8W110 FRO4 Ferric reduction oxidase 4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FIJ0 RBOHD Respiratory burst oxidase homolog protein D Arabidopsis thaliana (Mouse-ear cress) PR
Q9FJD6 RBOHH Putative respiratory burst oxidase homolog protein H Arabidopsis thaliana (Mouse-ear cress) PR
Q9SUT8 RBOHI Probable respiratory burst oxidase homolog protein I Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAARGRLVVA RGNRSFSSII RKYSLKRETN KKVIKNVIKL LTMVILMGTV VIWIMMPTST
70 80 90 100 110 120
YKKIWLKSMR AKLGKSIYFG KPGVNLLVYM FPMILLASLG SIYLHLKKQT RVNQFNSRMD
130 140 150 160 170 180
RKKIDKFGAL KRPMLVKAGL GIVTVTEVMF LMMFMALLLW SLANYFYHTF VTITPQSLPT
190 200 210 220 230 240
DGDNLWQARL DSIAVRLGLT GNICLGFLFY PVARGSSLLA AVGLTSESST KYHIWLGNLV
250 260 270 280 290 300
MTLFTSHGLC YCIYWISTNQ VSQMLEWDRT GISHLAGEIA LVAGLLMWAT TFPAIRRRFF
310 320 330 340 350 360
EVFFYTHYLY MVFMLFFVFH VGISYALISF PGFYIFMVDR FLRFLQSRNN VKLVSARVLP
370 380 390 400 410 420
CETVELNFSK NPMLMYSPTS ILFVNIPSIS KLQWHPFTIT SSSKLEPKKL SVMIKSQGKW
430 440 450 460 470 480
SSKLHHMLAS SNQIDHLAVS VEGPYGPAST DYLRHDSLVM VSGGSGITPF ISIIRDLLYV
490 500 510 520 530 540
SSTNAYKTPK ITLICAFKNS SDLSMLNLIL PNSTEISSFI DIQIKAFVTR EKVSTCNMNI
550 560 570 580 590 600
IKTLSFKPYV SDQPISPILG PNSWLWLATI LSSSFMIFII IIAIISRYHI YPIDQSSKEY
610 620 630 640 650 660
TSAYTSLIYL LAISISVVAT STVAMLCNKK SYFKGLYQNV DALSPLMIES SPDQLLPEFT
670 680 690 700 710
NIHYGERPNL NKLLVGLKGS SVGVLVCGPR KMREEVAKIC SFGSAANLQF ESISFNW