Q9FH04

PR
Gene name
At5g42250 (K5J14.5)
Protein name
Alcohol dehydrogenase-like 7
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G42250
EC number
1.1.1.1: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-60 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9FH04

Entry ID Method Resolution Chain Position Source
AF-Q9FH04-F1 Predicted AlphaFoldDB

44 variants for Q9FH04

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_5_16894092_A_T 2 E>D No 1000Genomes
ENSVATH03319694 14 H>L No 1000Genomes
ENSVATH03319695 16 P>A No 1000Genomes
ENSVATH12366704 22 A>V No 1000Genomes
ENSVATH03319699 27 A>V No 1000Genomes
tmp_5_16894300_C_G 40 P>A No 1000Genomes
ENSVATH03319704 66 Q>E No 1000Genomes
ENSVATH07299530 67 V>A No 1000Genomes
ENSVATH07299552 87 V>A No 1000Genomes
tmp_5_16895923_T_C 95 V>A No 1000Genomes
tmp_5_16895922_G_A 95 V>I No 1000Genomes
ENSVATH12366959 96 E>V No 1000Genomes
tmp_5_16895974_T_C 112 V>A No 1000Genomes
tmp_5_16895982_A_C 115 K>Q No 1000Genomes
ENSVATH00695926 137 D>E Plants were checked bi-weekly for presence of first buds and the average flowering time of 4 plants of the same accession were collected [10c and 16 hrs daylight] Plants were checked bi-weekly for presence of first buds and the average flowering time of 4 plants of the same accession were collected [16c and 16 hrs daylight] Plants were checked bi-weekly for presence of first buds and the average flowering time of 4 plants of the same accession were collected [22c and 16 hrs daylight] [EnsemblGenome] No 1000Genomes
ENSVATH12366964 145 L>V No 1000Genomes
ENSVATH07299553 146 N>H No 1000Genomes
ENSVATH03319774 148 E>A No 1000Genomes
ENSVATH03319773 148 E>Q No 1000Genomes
ENSVATH12366995 161 E>A No 1000Genomes
ENSVATH07299556 167 V>I No 1000Genomes
tmp_5_16896166_C_T 176 S>L No 1000Genomes
ENSVATH07299558 178 P>L No 1000Genomes
tmp_5_16896171_C_T 178 P>S No 1000Genomes
tmp_5_16896177_A_C 180 S>R No 1000Genomes
tmp_5_16896304_G_T 195 A>S No 1000Genomes
tmp_5_16896313_G_T 198 E>* No 1000Genomes
ENSVATH03319779 198 E>A No 1000Genomes
tmp_5_16896315_G_T 198 E>D No 1000Genomes
ENSVATH03319779 198 E>V No 1000Genomes
ENSVATH12366998 204 K>N No 1000Genomes
ENSVATH14566932 204 K>R No 1000Genomes
ENSVATH07299571 243 Q>E No 1000Genomes
tmp_5_16896861_T_A 256 S>T No 1000Genomes
tmp_5_16896865_T_A 257 M>K No 1000Genomes
ENSVATH07299575 259 C>W No 1000Genomes
ENSVATH07299576 260 E>D No 1000Genomes
ENSVATH07299578 262 N>K No 1000Genomes
tmp_5_16896880_A_C 262 N>T No 1000Genomes
ENSVATH03319815 273 D>G No 1000Genomes
ENSVATH12367117 285 S>T No 1000Genomes
ENSVATH12367118 293 Y>F No 1000Genomes
ENSVATH12367120 330 M>I No 1000Genomes
tmp_5_16897295_A_G 340 K>E No 1000Genomes

No associated diseases with Q9FH04

7 regional properties for Q9FH04

Type Name Position InterPro Accession
domain DNA topoisomerase, type IA, domain 2 146 - 242 IPR003601
domain DNA topoisomerase, type IA, DNA-binding domain 289 - 545 IPR003602
domain TOPRIM domain 3 - 155 IPR006171
domain DNA topoisomerase, type IA, central 112 - 125 IPR013497-1
domain DNA topoisomerase, type IA, central 170 - 593 IPR013497-2
active_site DNA topoisomerase, type IA, active site 326 - 340 IPR023406
domain DNA topoisomerase 3-like, TOPRIM domain 3 - 167 IPR034144

Functions

Description
EC Number 1.1.1.1 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
alcohol dehydrogenase activity, zinc-dependent Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of zinc.
S-(hydroxymethyl)glutathione dehydrogenase activity Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
formaldehyde catabolic process The chemical reactions and pathways resulting in the breakdown of formaldehyde (methanal, H2C=O), the simplest aldehyde.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q0V7W6 At4g22110 Alcohol dehydrogenase-like 5 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MENGNSSSDN KSSHKPIRCK AAVSRKAGEP LVMEEIMVAP PQPFEVRIRI ICTALCHSDV
70 80 90 100 110 120
TFWKLQVPPA CFPRILGHEA IGVVESVGEN VKEVVEGDTV LPTFMPDCGD CVDCKSHKSN
130 140 150 160 170 180
LCSKFPFKVS PWMPRYDNSS RFTDLNGETL FHFLNVSSFS EYTVLDVANV VKIDSSIPPS
190 200 210 220 230 240
RACLLSCGVS TGVGAAWETA KVEKGSTVVI FGLGSIGLAV AEGARLCGAS RIIGVDINPT
250 260 270 280 290 300
KFQVGQKFGV TEFVNSMTCE KNRVSEVINE MTDGGADYCF ECVGSSSLVQ EAYACCRQGW
310 320 330 340 350 360
GKTITLGVDK PGSQICLDSF DVLHHGKILM GSLFGGLKAK THIPILLKRY LSNELELDKF
370 380
VTHEMKFEEI NDAFQLLLEG KCIRCVLWMG