Q9ES00
PR
Gene name |
Ube4b |
Protein name |
Ubiquitin conjugation factor E4 B |
Names |
RING-type E3 ubiquitin transferase E4 B, Ubiquitin fusion degradation protein 2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:63958 |
EC number |
2.3.2.27: Aminoacyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q9ES00
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2KR4 | NMR | - | A | 1092-1173 | PDB |
| AF-Q9ES00-F1 | Predicted | AlphaFoldDB |
43 variants for Q9ES00
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388731602 | 30 | T>K | No | EVA | |
| rs3388721594 | 32 | P>S | No | EVA | |
| rs3388738061 | 124 | S>T | No | EVA | |
| rs3388732047 | 170 | W>* | No | EVA | |
| rs3388718335 | 264 | S>C | No | EVA | |
| rs3388718257 | 307 | R>* | No | EVA | |
| rs3388733799 | 375 | E>K | No | EVA | |
| rs3395112717 | 408 | E>D | No | EVA | |
| rs3388729110 | 422 | L>V | No | EVA | |
| rs3388734374 | 457 | Q>R | No | EVA | |
| rs3388709263 | 476 | A>S | No | EVA | |
| rs3388738052 | 499 | S>T | No | EVA | |
| rs3388709232 | 530 | S>I | No | EVA | |
| rs3388725692 | 569 | S>N | No | EVA | |
| rs3388721607 | 595 | E>D | No | EVA | |
| rs3388734673 | 606 | N>K | No | EVA | |
| rs3388734683 | 658 | N>S | No | EVA | |
| rs3388732021 | 672 | K>* | No | EVA | |
| rs3388732021 | 672 | K>E | No | EVA | |
| rs3388727184 | 680 | H>Q | No | EVA | |
| rs3395083644 | 810 | F>I | No | EVA | |
| rs3394980956 | 810 | F>Y | No | EVA | |
| rs3395081387 | 830 | H>P | No | EVA | |
| rs3388721572 | 865 | Y>F | No | EVA | |
| rs3388731595 | 881 | H>Q | No | EVA | |
| rs3388725668 | 893 | Q>R | No | EVA | |
| rs3388729063 | 903 | N>D | No | EVA | |
| rs3388732344 | 931 | Q>R | No | EVA | |
| rs3388732123 | 961 | A>V | No | EVA | |
| rs3388718250 | 998 | Q>* | No | EVA | |
| rs3388734903 | 1001 | G>V | No | EVA | |
| rs3388738055 | 1013 | E>V | No | EVA | |
| rs3388727206 | 1014 | K>S | No | EVA | |
| rs3388741015 | 1026 | L>M | No | EVA | |
| rs3388718254 | 1027 | T>I | No | EVA | |
| rs3388731615 | 1035 | C>Y | No | EVA | |
| rs3388734441 | 1046 | Q>L | No | EVA | |
| rs3388732336 | 1048 | S>F | No | EVA | |
| rs3388734429 | 1064 | A>T | No | EVA | |
| rs3388729112 | 1114 | D>V | No | EVA | |
| rs3395138172 | 1123 | V>I | No | EVA | |
| rs3388734725 | 1166 | R>K | No | EVA | |
| rs3395136846 | 1174 | H>E | No | EVA |
No associated diseases with Q9ES00
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.2.27 | Aminoacyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| ubiquitin ligase complex | A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATPase binding | Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP. |
| enzyme binding | Binding to an enzyme, a protein with catalytic activity. |
| ubiquitin protein ligase activity | Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues. |
| ubiquitin-ubiquitin ligase activity | Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin -> Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue. |
| unfolded protein binding | Binding to an unfolded protein. |
14 GO annotations of biological process
| Name | Definition |
|---|---|
| granzyme-mediated apoptotic signaling pathway | The series of molecular signals induced by granzymes which triggers the apoptotic death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of apoptosis is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce apoptosis in target cells. |
| neuron projection development | The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
| proteasome-mediated ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. |
| protein autoubiquitination | The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink. |
| protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. |
| protein folding | The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. |
| protein monoubiquitination | Addition of a single ubiquitin group to a protein. |
| protein polyubiquitination | Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain. |
| protein ubiquitination | The process in which one or more ubiquitin groups are added to a protein. |
| response to endoplasmic reticulum stress | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. |
| response to UV | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. |
| ubiquitin-dependent ERAD pathway | The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. |
| ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein. |
| ventricular trabecula myocardium morphogenesis | The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEELSADEIR | RRRLARLAGG | QTSQPTTPLT | SPQRENPPGP | PIAASAPGPS | QSLGLNVHNM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TPATSPIGAA | GVAHRSQSSE | GVSSLSSSPS | NSLETQSQSL | SRSQSMDIDG | VSCEKSMSQV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DVDSGIENME | VDENDRREKR | SLSDKEPSSG | PEVSEEQALQ | LVCKIFRVSW | KDRDRDVIFL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SSLSAQFKQN | PKEVFSDFKD | LIGQILMEVL | MMSTQTRDEN | PFASLTATSQ | PIATAARSPD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RNLMLNTGSS | SGTSPMFCNM | GSFSTSSLSS | LGASGGASNW | DSYSDHFTIE | TCKETDMLNY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LIECFDRVGI | EEKKAPKMCS | QPAVSQLLSN | IRSQCISHTA | LVLQGSLTQP | RSLQQPSFLV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PYMLCRNLPY | GFIQELVRTT | HQDEEVFKQI | FIPILQGLAL | AAKECSLESD | YFKYPLMALG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ELCETKFGKT | HPMCNLVASL | PLWLPKSLSP | GSGRELQRLS | YLGAFFSFSV | FAEDDAKVVE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KYFSGPAITL | ENTRVVSQSL | QHYLELGRQE | LFKILHSILL | NGETREAALS | YMAALVNANM |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KKAQMQADDR | LVSTDGFMLN | LLWVLQQLST | KIKLETVDPT | YIFHPRCRIT | LPNDETRINA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TMEDVNERLT | ELYGDQPPFS | EPKFPTECFF | LTLHAHHLSI | LPSCRRYIRR | LRAIRELNRT |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VEDLKNNESQ | WKDSPLATRH | REMLKRCKTQ | LKKLVRCKAC | ADAGLLDESF | LRRCLNFYGL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LIQLMLRILD | PAYPDVTLPL | NSEVPKVFAA | LPEFYVEDVA | EFLFFIVQYS | PQVLYEPCTQ |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DIVMFLVVML | CNQNYIRNPY | LVAKLVEVMF | MTNPSVQPRT | QKFFEMIENH | PLSTKLLVPS |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LMKFYTDVEH | TGATSEFYDK | FTIRYHISTI | FKSLWQNIAH | HGTFMEEFNS | GKQFVRYINM |
| 910 | 920 | 930 | 940 | 950 | 960 |
| LINDTTFLLD | ESLESLKRIH | EVQEEMKNKE | QWDQLPRDQQ | QARQSQLAQD | ERVSRSYLAL |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| ATETVDMFHL | LTKQVQKPFL | RPELGPRLAA | MLNFNLQQLC | GPKCRDLKVE | NPEKYGFEPK |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| KLLDQLTDIY | LQLDCARFAK | AIADDQRSYS | KELFEEVISK | MRKAGIKSTI | AIEKFKLLAE |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| KVEEIVAKNA | RAEIDYSDAP | DEFRDPLMDT | LMTDPVRLPS | GTVMDRSIIL | RHLLNSPTDP |
| 1150 | 1160 | 1170 | |||
| FNRQMLTESM | LEPVPELKEQ | IQAWMREKQS | SDH |