Q9EQI8
Gene name |
Mrpl46 |
Protein name |
39S ribosomal protein L46, mitochondrial |
Names |
L46mt, MRP-L46 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:67308 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9EQI8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9EQI8-F1 | Predicted | AlphaFoldDB |
15 variants for Q9EQI8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs241832457 | 17 | R>Q | No | EVA | |
| rs235711811 | 30 | L>F | No | EVA | |
| rs3388917640 | 55 | P>S | No | EVA | |
| rs243907232 | 75 | I>V | No | EVA | |
| rs3388916064 | 100 | K>R | No | EVA | |
| rs3388913084 | 102 | D>E | No | EVA | |
| rs3388878174 | 116 | Q>* | No | EVA | |
| rs218309196 | 133 | A>T | No | EVA | |
| rs36720558 | 154 | N>S | No | EVA | |
| rs3388898536 | 160 | R>S | No | EVA | |
| rs36984691 | 166 | Q>H | No | EVA | |
| rs224026949 | 175 | E>K | No | EVA | |
| rs3388906732 | 179 | G>W | No | EVA | |
| rs3388911670 | 184 | G>R | No | EVA | |
| rs13464381 | 220 | Q>R | No | EVA |
No associated diseases with Q9EQI8
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell junction | A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. |
| mitochondrial inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. |
| mitochondrial large ribosomal subunit | The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site). |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| structural constituent of ribosome | The action of a molecule that contributes to the structural integrity of the ribosome. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| mitochondrial translation | The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code. |
3 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAPVGRTLL | GLARGWRQLD | RFWAGSSRGL | SLEAASSSSR | SPWRLSGALC | LQRPPLITKA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LTPLQEEMAG | LLQQIEVERS | LYSDHELRAL | DEAQRLAKKK | ADLYDEEQEQ | GITLAQDLED |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MWEQAFLQFR | PGARETEADK | KNDRTSLHRK | LDRNLVLLVR | EKLGDQDVWM | LPQVEWQPGE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TLRGTAERIL | ATLSENNMEA | KFLGNAPCGH | YKFKFPKAIQ | TESDLGVKVF | FFKALLLTGD |
| 250 | 260 | 270 | 280 | ||
| FVQAGKKSRH | VWASKEELGD | YLQPKYLAQV | RRFLLDSDGL | SCL |