Q3SZ22
Gene name |
MRPL46 |
Protein name |
39S ribosomal protein L46, mitochondrial |
Names |
L46mt, MRP-L46 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:540720 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3SZ22
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3SZ22-F1 | Predicted | AlphaFoldDB |
68 variants for Q3SZ22
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs716977241 | 5 | T>R | No | EVA | |
| rs457535469 | 8 | T>S | No | EVA | |
| rs447244006 | 9 | V>A | No | EVA | |
| rs478732297 | 11 | G>E | No | EVA | |
| rs441722295 | 13 | A>E | No | EVA | |
| rs476808758 | 15 | C>* | No | EVA | |
| rs463157104 | 16 | W>S | No | EVA | |
| rs724028898 | 18 | R>W | No | EVA | |
| rs41973399 | 19 | F>L | No | EVA | |
| rs471337039 | 20 | E>G | No | EVA | |
| rs454118006 | 21 | S>C | No | EVA | |
| rs475114949 | 23 | W>G | No | EVA | |
| rs469760235 | 30 | L>F | No | EVA | |
| rs456184934 | 31 | T>A | No | EVA | |
| rs456184934 | 31 | T>S | No | EVA | |
| rs464320795 | 35 | A>P | No | EVA | |
| rs464320795 | 35 | A>S | No | EVA | |
| rs478613639 | 37 | S>P | No | EVA | |
| rs468217050 | 39 | S>R | No | EVA | |
| rs482782387 | 40 | A>E | No | EVA | |
| rs448041821 | 40 | A>S | No | EVA | |
| rs439882431 | 41 | S>T | No | EVA | |
| rs477671643 | 44 | R>S | No | EVA | |
| rs133320623 | 46 | L>M | No | EVA | |
| rs454921115 | 47 | G>V | No | EVA | |
| rs475750398 | 48 | A>P | No | EVA | |
| rs456172586 | 53 | R>G | No | EVA | |
| rs464208288 | 55 | P>Q | No | EVA | |
| rs468107298 | 58 | S>A | No | EVA | |
| rs482787110 | 60 | Q>E | No | EVA | |
| rs469095948 | 61 | L>V | No | EVA | |
| rs446244038 | 62 | T>P | No | EVA | |
| rs477561048 | 63 | P>T | No | EVA | |
| rs460762501 | 64 | M>R | No | EVA | |
| rs440644385 | 66 | E>A | No | EVA | |
| rs461296786 | 71 | L>V | No | EVA | |
| rs135824281 | 72 | L>Q | No | EVA | |
| rs475693378 | 73 | Q>P | No | EVA | |
| rs458866171 | 76 | E>G | No | EVA | |
| rs1116612874 | 107 | K>E | No | EVA | |
| rs472988556 | 124 | Q>E | No | EVA | |
| rs479988881 | 170 | M>I | No | EVA | |
| rs463192095 | 181 | T>P | No | EVA | |
| rs1117499393 | 191 | A>T | No | EVA | |
| rs481436444 | 196 | N>T | No | EVA | |
| rs461184999 | 199 | E>K | No | EVA | |
| rs444459093 | 200 | A>D | No | EVA | |
| rs475756536 | 202 | F>L | No | EVA | |
| rs439418758 | 208 | C>R | No | EVA | |
| rs470786925 | 210 | H>Q | No | EVA | |
| rs453968709 | 211 | Y>* | No | EVA | |
| rs454561553 | 218 | A>G | No | EVA | |
| rs474555208 | 218 | A>S | No | EVA | |
| rs437696083 | 219 | V>E | No | EVA | |
| rs797890724 | 220 | R>W | No | EVA | |
| rs469101988 | 221 | A>G | No | EVA | |
| rs452608307 | 222 | E>Q | No | EVA | |
| rs432526876 | 223 | G>D | No | EVA | |
| rs467160865 | 226 | G>E | No | EVA | |
| rs447093098 | 227 | A>T | No | EVA | |
| rs467595013 | 230 | F>L | No | EVA | |
| rs450826274 | 231 | F>L | No | EVA | |
| rs458844958 | 235 | L>R | No | EVA | |
| rs438905415 | 240 | D>A | No | EVA | |
| rs799611068 | 243 | P>L | No | EVA | |
| rs477189281 | 247 | K>E | No | EVA | |
| rs384866025 | 250 | H>Y | No | EVA | |
| rs460309092 | 258 | L>P | No | EVA |
No associated diseases with Q3SZ22
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell junction | A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. |
| mitochondrial inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. |
| mitochondrial large ribosomal subunit | The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site). |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| structural constituent of ribosome | The action of a molecule that contributes to the structural integrity of the ribosome. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
3 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAPTRRTVL | GLARCWRRFE | SPWSLGSRSL | TLAAAPSNSA | SPWRLLGALC | LQRPPLVSKQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LTPMQEEMAA | LLQQMEIERS | LYSDHELRAL | DEAEQLEKKK | SDLYEEKDEK | NILLVQDLED |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MWEQKFLQFK | PGARITDADV | KNDRSSLHRK | LDRNLILLVK | DKLGDQDVWM | LPQAEWQPGE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TLRQTAERTL | ATLSENNLEA | KFLGNAPCGH | YKFKFPQAVR | AEGSLGAKIF | FFKALLLTGD |
| 250 | 260 | 270 | |||
| FSPAVEKGRH | VWASKEELGD | YLKPKYLAQV | RRFLLDL |