Q9DC37
Gene name |
Mfsd1 |
Protein name |
Major facilitator superfamily domain-containing protein 1 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:66868 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9DC37
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9DC37-F1 | Predicted | AlphaFoldDB |
16 variants for Q9DC37
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs221056064 | 15 | R>H | No | EVA | |
| rs3388626637 | 144 | V>M | No | EVA | |
| rs3388636642 | 147 | I>T | No | EVA | |
| rs3388626675 | 150 | E>* | No | EVA | |
| rs3388623229 | 162 | S>N | No | EVA | |
| rs3388630310 | 188 | M>V | No | EVA | |
| rs235335315 | 201 | L>S | No | EVA | |
| rs3388638041 | 244 | K>I | No | EVA | |
| rs3388628646 | 259 | K>E | No | EVA | |
| rs3388636606 | 267 | L>V | No | EVA | |
| rs30917245 | 270 | V>I | No | EVA | |
| rs3393175126 | 290 | F>S | No | EVA | |
| rs235137400 | 342 | V>L | No | EVA | |
| rs247258286 | 379 | I>V | No | EVA | |
| rs30921089 | 392 | M>T | No | EVA | |
| rs3388632111 | 449 | N>S | No | EVA |
No associated diseases with Q9DC37
1 regional properties for Q9DC37
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Major facilitator superfamily domain | 41 - 444 | IPR020846 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| lysosomal membrane | The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. |
| lysosome | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| transmembrane transporter activity | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| protein localization to lysosome | A process in which a protein is transported to, or maintained in, a location within a lysosome. |
| protein stabilization | Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q1JQC1 | MFSD1 | Major facilitator superfamily domain-containing protein 1 | Bos taurus (Bovine) | PR |
| Q5ZIT9 | MFSD1 | Major facilitator superfamily domain-containing protein 1 | Gallus gallus (Chicken) | PR |
| Q9H3U5 | MFSD1 | Major facilitator superfamily domain-containing protein 1 | Homo sapiens (Human) | PR |
| Q32LQ6 | mfsd1 | Major facilitator superfamily domain-containing protein 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEDEDGEDRA | LLGGRREADS | AVHGAPRALS | ALCDPSRLAH | RLVVLSLMCF | LGFGSYFCYD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NPAALQTQVK | RDMQVNTTKF | MLLYAWYSWP | NVVLCFLGGF | LIDRIFGIRW | GTVIFSCFVC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IGQVIFALGG | IFNAFWLMEL | GRFVFGIGGE | SLAVAQNTYA | VSWFKGKELN | LVFGLQLSMA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RIGSTVNMNL | MGWLYGKIEA | LLGSAGHMTL | GVTLMIGCIT | CIFSLICALA | LAYLDRRAEK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ILHKEQGKTG | EVIKLRDIKD | FSLPLILVFV | ICVCYYVAVF | PFIGLGKVFF | MEKFRFSSQS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ASAINSIVYI | ISAPMSPLFG | LLVDKTGKNI | IWVLYAVAAT | LVSHMMLAFT | FWNPWIAMCL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LGFSYSLLAC | ALWPMVAFIV | PEHQLGTAYG | FMQSIQNLGL | AVIAILAGMI | LDSKGYLLLE |
| 430 | 440 | 450 | 460 | ||
| VFFIACVSLS | LLAVVCLYLV | NRAQGGNLNY | SAKQRERMKL | SHPE |