Q32LQ6

PR
Gene name
mfsd1 (zgc:123187)
Protein name
Major facilitator superfamily domain-containing protein 1
Names
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:641486
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-55 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q32LQ6

Entry ID Method Resolution Chain Position Source
AF-Q32LQ6-F1 Predicted AlphaFoldDB

No variants for Q32LQ6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q32LQ6

No associated diseases with Q32LQ6

1 regional properties for Q32LQ6

Type Name Position InterPro Accession
domain Major facilitator superfamily domain 37 - 443 IPR020846

Functions

Description
EC Number
Subcellular Localization
  • Lysosome membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
lysosomal membrane The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
lysosome A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.

2 GO annotations of molecular function

Name Definition
protein homodimerization activity Binding to an identical protein to form a homodimer.
transmembrane transporter activity Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

2 GO annotations of biological process

Name Definition
protein localization to lysosome A process in which a protein is transported to, or maintained in, a location within a lysosome.
protein stabilization Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q1JQC1 MFSD1 Major facilitator superfamily domain-containing protein 1 Bos taurus (Bovine) PR
Q5ZIT9 MFSD1 Major facilitator superfamily domain-containing protein 1 Gallus gallus (Chicken) PR
Q9H3U5 MFSD1 Major facilitator superfamily domain-containing protein 1 Homo sapiens (Human) PR
Q9DC37 Mfsd1 Major facilitator superfamily domain-containing protein 1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MADREEHQGL LDGDRDEDEG DKAPSVHLNP ICDPNHLLHR ILVLIFMCFL GFGSYFCYDN
70 80 90 100 110 120
PAALQSQVIQ DMNLNTASFM QLYAWYSWPN VVLCFLGGFL LDRVFGIRLG TVIFSLFVLV
130 140 150 160 170 180
GQIIFAAGAL ANHFWLMNVG RFVFGIGGES LAVAQNTYAV NWFKGKELNL VFGLQLSMAR
190 200 210 220 230 240
LGSTVNMNVI GWVYGRIQMS MGSAGPTTLG ITLMIAASTC LFSLICALVL GFLDKRAERI
250 260 270 280 290 300
LNKEQGKTGE VIKLTDVKDF SVSLWLIFII CVAYYVAIFP FIGLGQVFFI EKFGFTPVQA
310 320 330 340 350 360
RAINSVVYII SAPASPLLGF LVDKTGRNVM WVMLAVITTL LSHMMLAFTF WNPWIAMSLL
370 380 390 400 410 420
GVSYSLLACA LWPMVAFVVP EHQLGTAYGF MQSIQNLGLA VMSIAAGSIL DVRGYLFLEV
430 440 450 460
FFIACLCMAL LAVVLLYLFD YYKEGGLNLS AATRSKRAKP E