Q9DBY8

PR
Gene name
Nvl
Protein name
Nuclear valosin-containing protein-like
Names
NVLp, Nuclear VCP-like protein
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:67459
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

91-256 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q9DBY8

Entry ID Method Resolution Chain Position Source
2RRE NMR - A 1-74 PDB
AF-Q9DBY8-F1 Predicted AlphaFoldDB

46 variants for Q9DBY8

Variant ID(s) Position Change Description Diseaes Association Provenance
rs259359459 6 G>A No EVA
rs3388523033 7 V>I No EVA
rs3388523074 16 R>G No EVA
rs3388520377 65 I>K No EVA
rs3388520358 68 S>I No EVA
rs238546158 76 K>R No EVA
rs3388524330 91 E>D No EVA
rs218298034 96 T>P No EVA
rs3388523417 99 Y>N No EVA
rs32753958 106 M>I No EVA
rs258452003 113 Q>R No EVA
rs256028156 117 P>H No EVA
rs248706985 128 R>K No EVA
rs259710695 132 E>D No EVA
rs234274508 136 T>S No EVA
rs220574822 137 T>A No EVA
rs251354052 140 W>L No EVA
rs230922114 141 G>E No EVA
rs3391088571 146 T>P No EVA
rs245989955 157 G>D No EVA
rs226707733 159 V>M No EVA
rs3388522470 170 G>R No EVA
rs3388518282 182 K>E No EVA
rs3388516121 246 Q>H No EVA
rs3388523442 248 K>R No EVA
rs3388522052 262 K>N No EVA
rs3388523020 266 V>A No EVA
rs3391115277 301 L>P No EVA
rs3388522484 313 L>H No EVA
rs3388522487 327 K>R No EVA
rs32754698 351 Q>H No EVA
rs215346488 374 V>I No EVA
rs265482374 402 R>Q No EVA
rs51443741 476 L>F No EVA
rs3388516528 478 R>Q No EVA
rs3388521966 490 M>K No EVA
rs32753816 513 E>K No EVA
rs3388524289 529 R>S No EVA
rs3388518334 573 T>I No EVA
rs3413052871 606 F>V No EVA
rs3388518531 748 P>L No EVA
rs3388524332 760 I>T No EVA
rs3388522574 772 D>V No EVA
rs3388522907 775 L>M No EVA
rs3388518280 776 E>D No EVA
rs32751966 844 V>M No EVA

No associated diseases with Q9DBY8

9 regional properties for Q9DBY8

Type Name Position InterPro Accession
domain AAA+ ATPase domain 296 - 435 IPR003593-1
domain AAA+ ATPase domain 613 - 749 IPR003593-2
domain ATPase, AAA-type, core 300 - 430 IPR003959-1
domain ATPase, AAA-type, core 617 - 746 IPR003959-2
conserved_site ATPase, AAA-type, conserved site 403 - 421 IPR003960-1
conserved_site ATPase, AAA-type, conserved site 717 - 735 IPR003960-2
domain NVL2, nucleolin binding domain 2 - 71 IPR031996
domain AAA ATPase, AAA+ lid domain 460 - 489 IPR041569-1
domain AAA ATPase, AAA+ lid domain 772 - 828 IPR041569-2

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
  • Nucleus, nucleoplasm
  • Associates with pre-ribosomal particles in the nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
nuclear exosome (RNase complex) A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
telomerase holoenzyme complex Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
preribosome binding Binding to a preribosome.

6 GO annotations of biological process

Name Definition
positive regulation of protein binding Any process that activates or increases the frequency, rate or extent of protein binding.
positive regulation of telomerase activity Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
regulation of protein localization to nucleolus Any process that modulates the frequency, rate or extent of protein localization to nucleolus.
ribosomal large subunit biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.
ribosome biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O15381 NVL Nuclear valosin-containing protein-like Homo sapiens (Human) PR
10 20 30 40 50 60
MKPRPGVFVD RKLKQRVIQY LSSNRCGKYV DTGILASDLQ RLYSVDYGRR KRNAFRIQVE
70 80 90 100 110 120
KVFSIISSEK ELKNLKELED GHLAKRARQD EEDEYTESYS DDDSNMEDYP DPQSANPMNS
130 140 150 160 170 180
SLLSLYRRGN SESVSTTPKW GQREATTSTP LLTSKTGSVP LKTPARESEG GWFIDKTPGG
190 200 210 220 230 240
KKESLPLDLS DDQSNSKKQD SEIQILKDSS LLESDKKRKG RAKGKGNKRK TENLQEVDGE
250 260 270 280 290 300
IEALLQKKAK ARSTELQISN VKFEDVGGND ATLKEVCKML IHMRHPEVYQ HLGVVPPRGV
310 320 330 340 350 360
LLHGPPGCGK TLLAHAIAGE LDLPILKVAA PEIVSGVSGE SEQKLRELFD QAVSNAPCIV
370 380 390 400 410 420
FIDEIDAITP KREVASKDME RRIVAQLLTC MDDLNNVAAT ARVLVIGATN RPDSLDPALR
430 440 450 460 470 480
RAGRFDREVC LGIPDEAARE RILQTLCRKL RLPETFNFCH LAHLTPGFVG ADLMALCREA
490 500 510 520 530 540
AMCAVNRVLM KQQAQQKKKP EIEGLPSEGD QEERLGAEPT SETQDELQRL LGLLRDQDPL
550 560 570 580 590 600
SEEQMQGLCI ELNDFIVALA EVQPSAKREG FVTVPNVTWA DIGALEDIRD ELIMAILAPV
610 620 630 640 650 660
RNPDQFRTLG LGTPAGILLA GPPGCGKTLL AKAVANESGL NFISVKGPEL LNMYVGESER
670 680 690 700 710 720
AVRQVFQRAK NSAPCVIFFD EVDALCPRRS DRETGASVRV VNQLLTEMDG LETRQQVFIL
730 740 750 760 770 780
AATNRPDIID PAILRPGRLD KTLFVGLPPP ADRVAILKTI TKNGTKPPLD EDVNLETIAN
790 800 810 820 830 840
DLRCNCYTGA DLTALVREAS LCALRQEITA QKNGVGAGEL KVSHKHFEDA FKKVKPSISI
850
KDQVMYEALQ RSLSQ