Q9DBX2
Gene name |
Pdcl (PhLP1) |
Protein name |
Phosducin-like protein |
Names |
PHLP |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:67466 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9DBX2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9DBX2-F1 | Predicted | AlphaFoldDB |
4 variants for Q9DBX2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs13470039 | 39 | I>S | No | EVA | |
| rs260917749 | 192 | V>I | No | EVA | |
| rs3388548498 | 232 | A>V | No | EVA | |
| rs244227119 | 286 | R>Q | No | EVA |
No associated diseases with Q9DBX2
1 regional properties for Q9DBX2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Phosducin, thioredoxin-like domain | 36 - 299 | IPR024253 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cilium | A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein-containing complex binding | Binding to a macromolecular complex. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| cell projection organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon. |
| heterotrimeric G-protein complex assembly | The aggregation, arrangement and bonding together of a set of components to form a heterotrimeric G-protein complex. |
| negative regulation of protein refolding | Any process that decreases the rate, frequency, or extent of protein refolding. Protein refolding is the process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones. |
| positive regulation of smoothened signaling pathway | Any process that activates or increases the frequency, rate or extent of smoothened signaling. |
| protein folding | The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. |
| regulation of G protein-coupled receptor signaling pathway | Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway. |
| response to stimulus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. |
| visual perception | The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTTLDDKLLG | EKLQYYYSTS | EDEDSDHEDK | DRGRGAPAIS | STPAEAELAG | EGISINTGPK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GVINDWRRFK | QLETEQREEQ | CREMERLIKK | LSMSCRSHLD | EEEEQQKQKD | LQEKISGKMT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LKEFGTKDKN | LDDEEFLQQY | RKQRMEEMRQ | QFHKGPQFKQ | VFEIPSGEGF | LDMIDKEQKS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TLIMVHIYED | GVPGTEAMNG | CMICLATEYP | AVKFCRVRSS | VIGASSRFTR | NALPALLIYK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AGELIGNFVR | VTDQLGEDFF | AVDLEAFLQE | FGLLPEKEVL | VLTSVRNSAT | CHSEDSDLEI |
| D |