AiPD: Autoinhibited Protein Database

Gene name	Dmgdh
Protein name	Dimethylglycine dehydrogenase, mitochondrial
Names	ME2GLYDH
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:74129
EC number	1.5.8.4: With a flavin as acceptor
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

821-869 (Predicted disordered autoinhibitory region) PR

821-869 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9DBT9-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3404286939	10	R>G	No	EVA
rs3404614188	12	L>P	No	EVA
rs3404804174	14	L>Q	No	EVA
rs3389294674	39	W>*	No	EVA
rs3389313513	104	D>G	No	EVA
rs3389224706	150	H>Q	No	EVA
rs3389254566	190	S>Y	No	EVA
rs3389280891	263	H>R	No	EVA
rs3389304698	266	V>I	No	EVA
rs3389270644	286	D>G	No	EVA
rs3389270667	286	D>Y	No	EVA
rs3389299557	328	K>M	No	EVA
rs3389299409	347	E>*	No	EVA
rs3389313508	383	N>Y	No	EVA
rs3389290059	387	A>T	No	EVA
rs3389299595	390	F>L	No	EVA
rs3389292060	405	S>N	No	EVA
rs3389263831	421	D>N	No	EVA
rs3389270693	491	K>T	No	EVA
rs3389294616	535	I>T	No	EVA
rs3389270689	561	S>G	No	EVA
rs3389313512	582	G>W	No	EVA
rs3389294904	586	L>V	No	EVA
rs3389289993	609	Y>*	No	EVA
rs3389299548	633	V>I	No	EVA
rs30382820	656	N>Y	No	EVA
rs3389263832	729	N>H	No	EVA
rs3389224667	749	G>E	No	EVA
rs30386353	758	T>A	No	EVA
rs3389294912	767	C>G	No	EVA
rs3389298832	770	V>M	No	EVA
rs247340973	774	D>N	No	EVA
rs3404067131	829	K>N	No	EVA
rs3404615087	830	N>I	No	EVA
rs3404505197	830	N>Y	No	EVA
rs3389224616	836	I>R	No	EVA
rs3389298773	841	V>I	No	EVA
rs3389224696	850	L>F	No	EVA
rs3389280959	857	T>I	No	EVA
rs3389280939	859	L>P	No	EVA
rs249020971	865	R>L	No	EVA

Type	Name	Position	InterPro Accession
domain	FAD dependent oxidoreductase	45 - 407	IPR006076
domain	Aminomethyltransferase, folate-binding domain	473 - 737	IPR006222
domain	Glycine cleavage T-protein, C-terminal barrel domain	763 - 840	IPR013977
domain	FAD dependent oxidoreductase, central domain	410 - 463	IPR032503

		Description
EC Number	1.5.8.4	With a flavin as acceptor
Subcellular Localization	Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
mitochondrial matrix	The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

Name	Definition
dimethylglycine dehydrogenase activity	Catalysis of the reaction: N,N-dimethylglycine + electron-transfer flavoprotein + H2O = sarcosine + formaldehyde + reduced electron-transfer flavoprotein.
flavin adenine dinucleotide binding	Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
folic acid binding	Binding to folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
oxidoreductase activity	Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Name	Definition
amino-acid betaine catabolic process	The chemical reactions and pathways resulting in the breakdown of any betaine, the N-trimethyl derivative of an amino acid.
choline catabolic process	The chemical reactions and pathways resulting in the breakdown of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.
tetrahydrofolate interconversion	The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q63342	Dmgdh	Dimethylglycine dehydrogenase, mitochondrial	Rattus norvegicus (Rat)	PR