Q63342

PR
Gene name
Dmgdh
Protein name
Dimethylglycine dehydrogenase, mitochondrial
Names
ME2GLYDH
Species
Rattus norvegicus (Rat)
KEGG Pathway
EC number
1.5.8.4: With a flavin as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-67 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for Q63342

Entry ID Method Resolution Chain Position Source
4P9S X-ray 232 A A/B 22-857 PDB
4PAA X-ray 226 A A/B 22-857 PDB
4PAB X-ray 185 A A/B 2-857 PDB
AF-Q63342-F1 Predicted AlphaFoldDB

No variants for Q63342

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q63342

No associated diseases with Q63342

8 regional properties for Q63342

Type Name Position InterPro Accession
repeat WD40 repeat 51 - 91 IPR001680-1
repeat WD40 repeat 101 - 140 IPR001680-2
repeat WD40 repeat 199 - 238 IPR001680-3
repeat WD40 repeat 242 - 279 IPR001680-4
repeat WD40 repeat 399 - 478 IPR001680-5
repeat WD40 repeat 504 - 543 IPR001680-6
domain Lethal giant larvae homologue 2 290 - 398 IPR013577
domain v-SNARE, coiled-coil homology domain 1094 - 1154 IPR042855

Functions

Description
EC Number 1.5.8.4 With a flavin as acceptor
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

4 GO annotations of molecular function

Name Definition
dimethylglycine dehydrogenase activity Catalysis of the reaction: N,N-dimethylglycine + electron-transfer flavoprotein + H2O = sarcosine + formaldehyde + reduced electron-transfer flavoprotein.
flavin adenine dinucleotide binding Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
folic acid binding Binding to folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

4 GO annotations of biological process

Name Definition
amino-acid betaine catabolic process The chemical reactions and pathways resulting in the breakdown of any betaine, the N-trimethyl derivative of an amino acid.
choline catabolic process The chemical reactions and pathways resulting in the breakdown of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.
choline metabolic process The chemical reactions and pathways involving choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.
tetrahydrofolate interconversion The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9DBT9 Dmgdh Dimethylglycine dehydrogenase, mitochondrial Mus musculus (Mouse) PR
10 20 30 40 50 60
MLRLGALRLR GLALRSSQGR PSSAGLREGQ ESPPSPPEWK DRAETVIIGG GCVGVSLAYH
70 80 90 100 110 120
LAKAGMRDVV LLEKSELTAG STWHAAGLTT YFHPGINLKK IHYDSIKLYE RLEEETGQVV
130 140 150 160 170 180
GFHQPGSIRL ATTPERVDEF KYQMTRTNWH ATEQYIIEPE KIHELFPLLN MDKILAGLYN
190 200 210 220 230 240
PGDGHIDPYS LTMALATGAR KYGVLLKYPA PVTSLKPRPD GTWDVETPQG SVRANRIVNA
250 260 270 280 290 300
AGFWAREVGK MIGLDHPLIP VQHQYVVTST IPEVKALKRE LPVLRDLEGS YYLRQERDGL
310 320 330 340 350 360
LFGPYESQEK MKLQASWVAH GVPPGFGKEL FESDLDRITE HVEAAMEMVP VLKKADIINI
370 380 390 400 410 420
VNGPITYSPD ILPMVGPHQG VRNYWVAIGF GYGIIHAGGV GKYLSDWILH GEPPFDLIEL
430 440 450 460 470 480
DPNRYGKWTT TQYTEAKARE SYGFNNIVGY PKEERFAGRP TQRVSGLYKI LESKCSMGFH
490 500 510 520 530 540
AGWEQPHWFY KPGQDTQYRP SFRRTNWFRP VGSEYKQVMQ RVGVIDLSPF GKFNIKGQDS
550 560 570 580 590 600
TQLLDHLCAN VIPKVGFTNI SHMLTPRGRV YAELTVSHQS PGEFLLITGS GSELHDLRWI
610 620 630 640 650 660
EEAAVRGGYD VEIRNITDEL GVLGVAGPYA RRVLQKLTSE DLSDDVFKFL QTKSLKISDI
670 680 690 700 710 720
PVTAIRISYT GELGWELYHR REDSAALYER IMNAGQEEGI DNFGTYALNA LRLEKAFRAW
730 740 750 760 770 780
GSEMNCDTNP LEAGLDYFIK LNKPADFTGK QALKQIKAKG LKRRLVCLTL ATDDVDPEGN
790 800 810 820 830 840
ESVWYKGKVI GNTTSGSYSY SIQKSLAFAY VPVELSEVGQ QVEVELLGKN YPATIIQEPL
850
VLTEPTRTRL QKDGRKS