AiPD: Autoinhibited Protein Database

Gene name	Izumo1
Protein name	Izumo sperm-egg fusion protein 1
Names	Oocyte binding/fusion factor, OBF, Sperm-specific protein izumo
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:73456
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

222-397 (Predicted disordered autoinhibitory region) PR

222-397 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
5B5K	X-ray	250 A	A	22-257	PDB
AF-Q9D9J7-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388907395	4	H>Q	No	EVA
rs3388913264	13	A>V	No	EVA
rs3388888235	16	L>M	No	EVA
rs227485349	43	D>N	No	EVA
rs256178251	45	L>V	No	EVA
rs3388913269	47	H>D	No	EVA
rs3388903529	55	R>W	No	EVA
rs214938285	59	H>L	No	EVA
rs3388911386	75	L>M	No	EVA
rs235294387	87	T>S	No	EVA
rs3388907403	103	K>E	No	EVA
rs246868647	150	L>F	No	EVA
rs3388888223	174	R>H	No	EVA
rs257412064	188	R>H	No	EVA
rs3388883267	199	Y>N	No	EVA
rs235071913	240	Q>E	No	EVA
rs3397879335	324	L>S	No	EVA
rs261586499	360	A>V	No	EVA
rs234410303	362	G>R	No	EVA
rs3388912745	373	M>K	No	EVA

Type	Name	Position	InterPro Accession
domain	Izumo protein, immunoglobulin domain	168 - 254	IPR032699

		Description
EC Number
Subcellular Localization	Cell membrane ; Single-pass type I membrane protein Cytoplasmic vesicle, secretory vesicle, acrosome membrane ; Single-pass type I membrane protein	Localizes initially to the acrosome membrane of the sperm head (both outer and inner acrosomal membranes) During the acrosome reaction, translocates to the plasma membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
acrosomal membrane	The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization.
acrosomal vesicle	A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
identical protein binding	Binding to an identical protein or proteins.
protein binding involved in heterotypic cell-cell adhesion	Binding to a protein or protein complex contributing to the adhesion of two different types of cells.
protein homodimerization activity	Binding to an identical protein to form a homodimer.
signaling receptor binding	Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

Name	Definition
cell adhesion	The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
fusion of sperm to egg plasma membrane involved in single fertilization	The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of single fertilization. In sperm with flagella, binding occurs at the posterior (post-acrosomal) region of the sperm head.
heterotypic cell-cell adhesion	The attachment of a cell to a cell of a different type via adhesion molecules.
single fertilization	The union of male and female gametes to form a zygote.
sperm-egg recognition	The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8IYV9	IZUMO1	Izumo sperm-egg fusion protein 1	Homo sapiens (Human)	PR
Q6AY06	Izumo1	Izumo sperm-egg fusion protein 1	Rattus norvegicus (Rat)	PR