Q9D4C5

PR
Gene name
Eaf1
Protein name
ELL-associated factor 1
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:74427
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

124-193 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9D4C5

Entry ID Method Resolution Chain Position Source
AF-Q9D4C5-F1 Predicted AlphaFoldDB

7 variants for Q9D4C5

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389331819 2 N>H No EVA
rs3389331734 35 Y>H No EVA
rs252255792 128 A>T No EVA
rs3389324976 132 Q>H No EVA
rs3405102345 229 P>A No EVA
rs3404929514 234 P>A No EVA
rs3389318219 253 L>F No EVA

No associated diseases with Q9D4C5

1 regional properties for Q9D4C5

Type Name Position InterPro Accession
domain Transcription elongation factor Eaf, N-terminal 16 - 113 IPR019194

Functions

Description
EC Number
Subcellular Localization
  • Nucleus speckle
  • Nucleus, Cajal body
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

9 GO annotations of cellular component

Name Definition
Cajal body A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA.
intercellular bridge A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised.
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
nuclear body Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
nuclear speck A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
super elongation complex A transcription elongation factor complex that increases the overall rate of RNA polymerase II transcription elongation by suppressing transient polymerase pausing. At minimum, the complex contains a transcription factor of the ELL family, an EAF protein, and an AFF family protein or distant relative and most likely also P-TEFb and AF9 or ENL. The complex is conserved from yeast to humans. In Schizosaccharomyces pombe it contains Ell1, Eaf1, and Ebp1, but it is absent from S. cerevisiae.
transcription elongation factor complex Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation.

1 GO annotations of molecular function

Name Definition
transcription elongation factor activity A molecular function that stimulates the elongation properties of the RNA polymerase during the elongation phase of transcription. A subclass of transcription elongation factors enable the transition from transcription initiation to elongation, while another class rescue stalled RNA polymerases.

3 GO annotations of biological process

Name Definition
positive regulation of DNA-templated transcription Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of transcription elongation by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5ZHP7 EAF2 ELL-associated factor 2 Gallus gallus (Chicken) PR
10 20 30 40 50 60
MNGTANPLLD REEHCLRLGE SFEKRPRASF HTIRYDFKPA SIDTSCEGEL QVGKGDEVTI
70 80 90 100 110 120
TLPHIPGSTP PMTVFKGNKR PYQKDCVLII NHDTGEYVLE KLSSSIQVKK TRAEGSSKIQ
130 140 150 160 170 180
ARMEQQPARP PQPSQPPPPP PPMPFRAPTK PPAGPKTSPL KDNPSPEPQL DDIKRELRAE
190 200 210 220 230 240
VDIIEQMSSS SGSSSSDSES SSGSDDDSSS SAGEDNGPAS PPQPSHQQPY NSRPAVANGT
250 260
SRPQGSSQLM NTLRNDLQLS ESGSDSDD