Q5ZHP7

PR
Gene name
EAF2 (RCJMB04_34m12)
Protein name
ELL-associated factor 2
Names
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:424243
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

142-220 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5ZHP7

Entry ID Method Resolution Chain Position Source
AF-Q5ZHP7-F1 Predicted AlphaFoldDB

No variants for Q5ZHP7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5ZHP7

No associated diseases with Q5ZHP7

1 regional properties for Q5ZHP7

Type Name Position InterPro Accession
domain Transcription elongation factor Eaf, N-terminal 16 - 113 IPR019194

Functions

Description
EC Number
Subcellular Localization
  • Nucleus speckle
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
nuclear speck A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
super elongation complex A transcription elongation factor complex that increases the overall rate of RNA polymerase II transcription elongation by suppressing transient polymerase pausing. At minimum, the complex contains a transcription factor of the ELL family, an EAF protein, and an AFF family protein or distant relative and most likely also P-TEFb and AF9 or ENL. The complex is conserved from yeast to humans. In Schizosaccharomyces pombe it contains Ell1, Eaf1, and Ebp1, but it is absent from S. cerevisiae.
transcription elongation factor complex Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation.

1 GO annotations of molecular function

Name Definition
transcription elongation factor activity A molecular function that stimulates the elongation properties of the RNA polymerase during the elongation phase of transcription. A subclass of transcription elongation factors enable the transition from transcription initiation to elongation, while another class rescue stalled RNA polymerases.

2 GO annotations of biological process

Name Definition
positive regulation of DNA-templated transcription Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
regulation of transcription elongation by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9D4C5 Eaf1 ELL-associated factor 1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MNGMAPPLFE PKERVLQLGE TFEKQPRCAF HTVRYDFKPA SIDTACEGDL EVGKGEQVTI
70 80 90 100 110 120
TLPNIEGSTP PVTVFKGSKK PYLKECILII NHDTGECRLE KLSSNITVKK IRAEGSSKVQ
130 140 150 160 170 180
SRIEQQQQQI RNSSKTPNNI KNSPPKDKMF PSSPMDDIER ELKAEASIMD QLSSSDSSSD
190 200 210 220 230 240
SKSSSSSSSS SENSSSDSED EEARPSLPMS MPYLQPQPTL SAIPHQAVPD KDASHNRSQE
250 260
NSGHMMNTLR SDLQLSESGS DSDD