Q9D489
PR
Gene name |
Sohlh2 (Tohlh2) |
Protein name |
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:74434 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9D489
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9D489-F1 | Predicted | AlphaFoldDB |
30 variants for Q9D489
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388631990 | 13 | R>M | No | EVA | |
| rs232602277 | 41 | P>S | No | EVA | |
| rs3388631956 | 91 | K>N | No | EVA | |
| rs3388633066 | 100 | A>T | No | EVA | |
| rs3388633011 | 147 | N>I | No | EVA | |
| rs3388631969 | 159 | Q>H | No | EVA | |
| rs3388633071 | 165 | L>F | No | EVA | |
| rs3388634539 | 175 | L>P | No | EVA | |
| rs255541198 | 186 | L>F | No | EVA | |
| rs3388612552 | 225 | T>M | No | EVA | |
| rs3388631595 | 232 | G>E | No | EVA | |
| rs3392685223 | 240 | V>D | No | EVA | |
| rs3392877207 | 241 | I>N | No | EVA | |
| rs3392998741 | 242 | E>D | No | EVA | |
| rs233778112 | 347 | Y>F | No | EVA | |
| rs252959825 | 350 | R>H | No | EVA | |
| rs216013203 | 353 | S>N | No | EVA | |
| rs3388625282 | 354 | T>I | No | EVA | |
| rs230820198 | 356 | R>L | No | EVA | |
| rs3388619126 | 377 | A>G | No | EVA | |
| rs3393108724 | 390 | P>H | No | EVA | |
| rs3388625632 | 392 | A>P | No | EVA | |
| rs3393066224 | 395 | V>G | No | EVA | |
| rs3392866371 | 396 | S>C | No | EVA | |
| rs3393103601 | 397 | N>K | No | EVA | |
| rs3388634568 | 403 | C>F | No | EVA | |
| rs3388631105 | 430 | R>C | No | EVA | |
| rs30565169 | 436 | I>V | No | EVA | |
| rs245965909 | 445 | A>D | No | EVA | |
| rs3388631976 | 468 | F>= | No | EVA |
No associated diseases with Q9D489
1 regional properties for Q9D489
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Myc-type, basic helix-loop-helix (bHLH) domain | 200 - 257 | IPR011598 |
Functions
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
8 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription activator activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. |
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| identical protein binding | Binding to an identical protein or proteins. |
| protein heterodimerization activity | Binding to a nonidentical protein to form a heterodimer. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
| RNA polymerase II transcription regulatory region sequence-specific DNA binding | Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II. |
| sequence-specific double-stranded DNA binding | Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| oocyte differentiation | The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| primary ovarian follicle growth | Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle). |
| regulation of gene expression | Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| spermatogenesis | The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3MHT3 | Sohlh2 | Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MADRISTGEL | GRRPGQGRVN | LLLVGDATRY | FLAGSMQKFF | PSTAQITLTI | SNVKKVAVLL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AANSFDIIFL | KVTSTLTAEE | QEAAKLIRSG | KKKNTHLLFA | FVIPERLKGY | VSEYGADISF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SEPLTLEKVN | TVIHYWKTYF | TNTDMENTEL | PPECRLYFQT | SRSELGGRFS | TDMFLCSELL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KNDARLGLKA | PLSSLDKSKQ | ASFLHSTKEK | LRRERIKSCC | EQLRTLLPYV | KGRKSDVASV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IEATVDYVKQ | VRESLSPAIM | AQVTEAIQNN | RRFSKRQMPI | ELFLPFSATS | QREDAMLTSA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FSPVQEIQLL | ADRGLNVYSM | TAAGGALEGA | VRGQPGSVSE | SSIEDLYKTR | VPSTARSLNS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FHSVKYTSGT | VSPHEAAART | NQNISTYLPP | TAPSVSNFIP | QHCNAMLCPA | RPTSPNCLCT |
| 430 | 440 | 450 | 460 | ||
| PGHELAASSR | AASASIFRGF | RAASASDHQA | SQPPALPSPQ | PHDSSYF |