Q3MHT3

PR
Gene name
Sohlh2
Protein name
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:619575
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

405-462 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3MHT3

Entry ID Method Resolution Chain Position Source
AF-Q3MHT3-F1 Predicted AlphaFoldDB

1 variants for Q3MHT3

Variant ID(s) Position Change Description Diseaes Association Provenance
rs198376906 336 G>D No EVA

No associated diseases with Q3MHT3

1 regional properties for Q3MHT3

Type Name Position InterPro Accession
domain Myc-type, basic helix-loop-helix (bHLH) domain 200 - 257 IPR011598

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

8 GO annotations of molecular function

Name Definition
DNA-binding transcription activator activity, RNA polymerase II-specific A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
identical protein binding Binding to an identical protein or proteins.
protein heterodimerization activity Binding to a nonidentical protein to form a heterodimer.
protein homodimerization activity Binding to an identical protein to form a homodimer.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
RNA polymerase II transcription regulatory region sequence-specific DNA binding Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
sequence-specific double-stranded DNA binding Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.

7 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
oocyte differentiation The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
primary ovarian follicle growth Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle).
regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
spermatogenesis The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9D489 Sohlh2 Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2 Mus musculus (Mouse) PR
10 20 30 40 50 60
MADRISTGEL GRRPGQGRVD LLLVGDATRY FLAGSVQKFF SSTAQITLTI SNVKKVAALL
70 80 90 100 110 120
AANSFDIIFL KVTSTLTAEE QEAVRLIRSG KKKNTHLLFA FVIPEKLRGY ISDYGADISF
130 140 150 160 170 180
NEPLTLEKVN TVINYWKTYF TNTDMGNTEL PPECRLYFQT SCSELGGHFP TDLFLCSELL
190 200 210 220 230 240
NNDTGLGLKA PLSSPERNKK ASFLHSSKEK LRRERIKFCC EQLRTLLPYV KGRKSDVASV
250 260 270 280 290 300
IEATVDYVKQ VRESLSPAIM AQITESLQSN KRFSKRQMPI ELFLPCTATS QRGDAMLTSA
310 320 330 340 350 360
FSPVQEIQLL ADQGLNVYSM PAAGGPLEEA VRGQPGSVSE DLYKTRVPST TLSLNSFHAV
370 380 390 400 410 420
RYCSGPVSPH EAAARTNQNI SIYLPPTGPS VSSFTPQHCN AMLCPTRPAS SSCLCTSGHE
430 440 450 460
LPASSRTASS SIFRGFRESD SGHQASQQPT GPSLQPQDSS YF