Q9D3A8
Gene name |
Nos1ap |
Protein name |
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein |
Names |
C-terminal PDZ ligand of neuronal nitric oxide synthase protein, Nitric oxide synthase 1 adaptor protein |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:70729 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9D3A8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9D3A8-F1 | Predicted | AlphaFoldDB |
30 variants for Q9D3A8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388514726 | 56 | R>H | No | EVA | |
| rs3388512230 | 59 | R>Q | No | EVA | |
| rs3388515661 | 107 | P>L | No | EVA | |
| rs3388514308 | 110 | R>G | No | EVA | |
| rs3388512227 | 113 | Y>C | No | EVA | |
| rs3388514645 | 118 | S>F | No | EVA | |
| rs3388514760 | 132 | A>V | No | EVA | |
| rs3388514680 | 158 | Q>R | No | EVA | |
| rs3388515178 | 160 | F>L | No | EVA | |
| rs3388511325 | 187 | S>I | No | EVA | |
| rs31457532 | 189 | G>S | No | EVA | |
| rs31460572 | 207 | A>T | No | EVA | |
| rs3388515618 | 233 | T>S | No | EVA | |
| rs31463194 | 274 | P>L | No | EVA | |
| rs3388510683 | 330 | R>* | No | EVA | |
| rs3388517414 | 334 | L>I | No | EVA | |
| rs3388512759 | 337 | Q>* | No | EVA | |
| rs3388514773 | 380 | A>T | No | EVA | |
| rs3390983395 | 396 | H>L | No | EVA | |
| rs3390894503 | 404 | L>W | No | EVA | |
| rs3391004829 | 406 | D>H | No | EVA | |
| rs3390983411 | 409 | H>N | No | EVA | |
| rs3390967916 | 409 | H>Q | No | EVA | |
| rs3388512212 | 465 | S>F | No | EVA | |
| rs3388511318 | 491 | Q>E | No | EVA | |
| rs3388509248 | 491 | Q>E | No | EVA | |
| rs3388515620 | 491 | Q>H | No | EVA | |
| rs3388514805 | 493 | L>M | No | EVA | |
| rs3388511284 | 493 | L>S | No | EVA | |
| rs3388511254 | 503 | V>M | No | EVA |
No associated diseases with Q9D3A8
1 regional properties for Q9D3A8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | PTB/PI domain | 27 - 173 | IPR006020 |
13 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| filopodium | Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nuclear membrane | Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| podosome | An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm. |
| postsynapse | The part of a synapse that is part of the post-synaptic cell. |
| presynapse | The part of a synapse that is part of the presynaptic cell. |
| sarcoplasmic reticulum membrane | The lipid bilayer surrounding the sarcoplasmic reticulum. |
| Z disc | Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| nitric-oxide synthase binding | Binding to nitric-oxide synthase. |
| PDZ domain binding | Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins. |
| protease binding | Binding to a protease or a peptidase. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| postsynaptic actin cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton. |
| regulation of heart rate by chemical signal | The regulation of the rate of heart contraction mediated by chemical signaling, hormonal, autocrine or paracrine. |
| regulation of ventricular cardiac muscle cell membrane repolarization | Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in a ventricular cardiomyocyte. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPSKTKYNLV | DDGHDLRIPL | HNEDAFQHGI | SFEAKYVGSL | DVPRPNSRVE | IVAAMRRIRY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EFKAKNIKKK | KVSIMVSVDG | VKVILKKKKK | KKEWTWDESK | MLVMQDPIYR | IFYVSHDSQD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LKIFSYIARD | GASNIFRCNV | FKSKKKSQAM | RIVRTVGQAF | EVCHKLSLQH | TQQNADGQED |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GESERNSDGS | GDPGRQLTGA | ERVSTAAAEE | TDIDAVEVPL | PGNDILEFSR | GVTDLDAVGK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DGGSHIDSTV | SPHPQEPMLT | ASPRMLLPSS | SSKPPGLGTG | TPLSTHHQMQ | LLQQLLQQQQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QQTQVAVAQV | HLLKDQLAAE | AAARLEAQAR | VHQLLLQNKD | MLQHISLLVK | QVQELELKLS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GQNTMGSQDS | LLEITFRSGA | LPVLCESTTP | KPEDLHSPLL | GAGLADFAHP | AGSPLGRHDC |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LVKLECFRFL | PPEDTQPMMA | QGEPLLGGLE | LIKFRESGIA | SEYESNTDES | EERDSWSQEE |
| 490 | 500 | ||||
| LPRLLNVLQR | QELGDSLDDE | IAV |