Q8K2A1

PR
Gene name
Gulp1 (Ced6)
Protein name
PTB domain-containing engulfment adapter protein 1
Names
Cell death protein 6 homolog, PTB domain adapter protein CED-6, Protein GULP
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:70676
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

154-226 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8K2A1

Entry ID Method Resolution Chain Position Source
AF-Q8K2A1-F1 Predicted AlphaFoldDB

7 variants for Q8K2A1

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389916639 6 S>SRKKGKNTDLAVKFSYLSFC* No EVA
rs3389917306 43 T>ASLTTSVPFGCSTSVLPRN* No EVA
rs46365462 118 S>F No EVA
rs3388467681 136 E>V No EVA
rs3388468788 151 K>* No EVA
rs3388467660 151 K>N No EVA
rs3388468011 165 Q>K No EVA

No associated diseases with Q8K2A1

1 regional properties for Q8K2A1

Type Name Position InterPro Accession
domain PTB/PI domain 22 - 158 IPR006020

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • May associate with the cytoplasmic side of the plasma membrane and early endosomes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
lipid transport The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
phagocytosis, engulfment The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9UBP9 GULP1 PTB domain-containing engulfment adapter protein 1 Homo sapiens (Human) PR
Q9D3A8 Nos1ap Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein Mus musculus (Mouse) PR
10 20 30 40 50 60
MNRAFSRKKD KTWMHTPEAL SKHYIPYNAK FLGSTEVEQP KGTEVVRDAV RKLKFARHIK
70 80 90 100 110 120
KSEGQKIPKV ELQISIYGVK ILEPKTKEVQ HNCQLHRISF CADDKTDKRI FTFICKDSES
130 140 150 160 170 180
NKHLCFVFDS EKCAEEITLT IGQAFDLAYR KFLESGGKDV ETRKQIAGMQ KRIQDLETEN
190 200 210 220 230 240
MELKNKVQDL ESRLRTTQVS TSPAHGVTVM SPSTDIFDMI PFSPISHQSP TSARNGTQLP
250 260 270 280 290 300
PIPSRSAETK RDLFGAEPFD PFNCGSGDFP PDIQSKLDEM QEGFKMGLTL EGTVFCLDPL
DSRC