AiPD: Autoinhibited Protein Database

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-51 (Predicted disordered autoinhibitory region) PR

1-51 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9D312-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3402291438	6	Q>E	No	EVA
rs3389197651	11	S>N	No	EVA
rs13481189	24	S>N	No	EVA
rs1135346617	28	Y>C	No	EVA
rs3389201812	31	G>E	No	EVA
rs3389136415	35	R>E*	No	EVA
rs3389201738	86	D>Y	No	EVA
rs226307514	121	I>V	No	EVA
rs3389201776	133	E>G	No	EVA
rs47126635	151	R>Q	No	EVA
rs250476481	160	E>D	No	EVA
rs29385411	173	R>H	No	EVA
rs3389199106	211	L>V	No	EVA
rs237792576	221	V>A	No	EVA
rs248977819	252	R>K	No	EVA
rs3389170200	259	K>R	No	EVA
rs3389188758	285	E>K	No	EVA
rs229895088	319	R>H	No	EVA
rs3389174959	329	A>V	No	EVA
rs3389174961	333	A>T	No	EVA
rs3389188755	385	D>H	No	EVA
rs1132884221	391	Y>C	No	EVA
rs3389211520	425	K>*	No	EVA

Type	Name	Position	InterPro Accession
conserved_site	Intermediate filament protein, conserved site	374 - 382	IPR018039
domain	Intermediate filament, rod domain	76 - 388	IPR039008

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton	A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
intermediate filament	A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins.

Name	Definition
structural molecule activity	The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.

Name	Definition
apoptotic process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
cellular response to starvation	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
epithelial cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
intermediate filament organization	Control of the spatial distribution of intermediate filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
regulation of protein secretion	Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q61781	Krt14	Keratin, type I cytoskeletal 14	Mus musculus (Mouse)	PR
P19001	Krt19	Keratin, type I cytoskeletal 19	Mus musculus (Mouse)	PR
Q9QWL7	Krt17	Keratin, type I cytoskeletal 17	Mus musculus (Mouse)	PR