Q9CY94

PR
Gene name
Gins3 (Psf3)
Protein name
DNA replication complex GINS protein PSF3
Names
GINS complex subunit 3
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:78833
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

159-216 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9CY94

Entry ID Method Resolution Chain Position Source
AF-Q9CY94-F1 Predicted AlphaFoldDB

11 variants for Q9CY94

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3399200599 26 L>M No EVA
rs3399514043 26 L>R No EVA
rs3389004462 87 E>K No EVA
rs3399486998 111 K>E No EVA
rs3399309887 111 K>N No EVA
rs3399474755 112 M>I No EVA
rs3399017059 113 G>R No EVA
rs3388954147 172 E>D No EVA
rs217589857 178 I>T No EVA
rs3389005438 182 S>T No EVA
rs3389001030 215 E>D No EVA

No associated diseases with Q9CY94

1 regional properties for Q9CY94

Type Name Position InterPro Accession
domain GINS subunit, domain A 67 - 173 IPR021151

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Chromosome
  • Associates with chromatin
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
CMG complex A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication.
GINS complex A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

4 GO annotations of biological process

Name Definition
DNA unwinding involved in DNA replication The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication.
mitotic DNA replication initiation Any DNA replication initiation involved in mitotic cell cycle DNA replication.
positive regulation of DNA primase activity Any process that activates or increases the frequency, rate or extent of DNA primase activity.
positive regulation of DNA-directed DNA polymerase activity Any process that activates or increases the frequency, rate or extent of DNA-directed DNA polymerase activity.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q12146 PSF3 DNA replication complex GINS protein PSF3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
10 20 30 40 50 60
MSEAYFPVES GALGPEENFL SLDDILMSQE KLPVRVETPM PRLGAFFLER GAGSEPDHPL
70 80 90 100 110 120
PQGTKLELPL WLAKGLFDHK RRILSVELPK MYQEGWRTVF SADANVVDLH KMGPHFYGFG
130 140 150 160 170 180
SQLLHFDSPE NADISQSLLK TFIGRFRRIM DSSQNSYNED TSALVARLDE TERGLFQIGQ
190 200 210
RSLNDFQSWE KGQASQITAS SLVQNYKKRK FTNMED