Q12146

PR
Gene name
PSF3
Protein name
DNA replication complex GINS protein PSF3
Names
Partner of Sld five 3
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YOL146W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

109-194 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

24 structures for Q12146

Entry ID Method Resolution Chain Position Source
3JC5 EM 470 A C 1-194 PDB
3JC6 EM 370 A C 1-194 PDB
3JC7 EM 480 A C 1-194 PDB
5U8S EM 610 A C 1-194 PDB
5U8T EM 490 A C 1-194 PDB
6HV9 EM 498 A E 1-194 PDB
6PTJ EM 380 A C 1-194 PDB
6PTN EM 580 A C/c 1-194 PDB
6PTO EM 700 A C/c/p 1-194 PDB
6SKL EM 370 A C 1-194 PDB
6U0M EM 390 A C 3-193 PDB
7PMK EM 320 A C 1-194 PDB
7QHS EM 330 A C 1-194 PDB
7Z13 EM 340 A C/J 1-194 PDB
8B9A EM 350 A E 1-194 PDB
8B9B EM 350 A E 1-194 PDB
8B9C EM 460 A E 1-194 PDB
8KG6 EM 307 A C 1-194 PDB
8KG8 EM 423 A C 1-194 PDB
8KG9 EM 452 A C 1-194 PDB
8W7M EM 412 A C 1-194 PDB
8W7S EM 739 A C 1-194 PDB
8XGC EM 370 A C 1-194 PDB
AF-Q12146-F1 Predicted AlphaFoldDB

2 variants for Q12146

Variant ID(s) Position Change Description Diseaes Association Provenance
s15-48962 34 P>A No SGRP
s15-48996 45 S>N No SGRP

No associated diseases with Q12146

1 regional properties for Q12146

Type Name Position InterPro Accession
domain GINS subunit, domain A 45 - 174 IPR021151

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
CMG complex A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication.
DNA replication preinitiation complex A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins might include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present.
GINS complex A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks.
nuclear replication fork The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
replication fork protection complex A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

6 GO annotations of biological process

Name Definition
DNA unwinding involved in DNA replication The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication.
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.
double-strand break repair via break-induced replication The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome.
mitotic DNA replication initiation Any DNA replication initiation involved in mitotic cell cycle DNA replication.
positive regulation of DNA primase activity Any process that activates or increases the frequency, rate or extent of DNA primase activity.
positive regulation of DNA-directed DNA polymerase activity Any process that activates or increases the frequency, rate or extent of DNA-directed DNA polymerase activity.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9CY94 Gins3 DNA replication complex GINS protein PSF3 Mus musculus (Mouse) PR
10 20 30 40 50 60
MGYYDIDDVL ADGTEFPCKF QYDIPGLGYL ENNPGRPITK NTKLSLPLWL ARILAIVGGD
70 80 90 100 110 120
EALVDEEPVP FVELLPPDMF STKVMNAIKT DPVALDLHSI NSHFFSLAIK WIMLFSEKEL
130 140 150 160 170 180
ANVVSELLLQ RAQELNHHAS SLSIDLNADS TGKNSANTNI ATSTFLLKLE EMEKEIYKKS
190
HESYKDTKRW MFKK