Q9CWH5

PR
Gene name
Trmt11
Protein name
tRNA (guanine(10)-N2)-methyltransferase homolog
Names
tRNA guanosine-2'-O-methyltransferase TRM11 homolog
Species
Mus musculus (Mouse)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

285-358 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9CWH5

Entry ID Method Resolution Chain Position Source
AF-Q9CWH5-F1 Predicted AlphaFoldDB

No variants for Q9CWH5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9CWH5

No associated diseases with Q9CWH5

2 regional properties for Q9CWH5

Type Name Position InterPro Accession
domain Ribosomal RNA large subunit methyltransferase K/L-like, FLD domain 190 - 320 IPR000241
conserved_site DNA methylase, N-6 adenine-specific, conserved site 305 - 311 IPR002052

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule.
tRNA (guanine-N2-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing guanine = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine.
tRNA binding Binding to a transfer RNA.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q12463 TRM11 tRNA (guanine(10)-N2)-methyltransferase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q6YJI5 TRMT11 tRNA (guanine(10)-N2)-methyltransferase homolog Gallus gallus (Chicken) PR
10 20 30 40 50 60
MALPGSLNRY LLLMAQEHLE FRLPEIKSLL SVIGGQFTNS QETYGKSPFW ILNIPSEDIA
70 80 90 100 110 120
RNLMKRTVCA KSIFELWGHG KSPEELYTSL KSYPVEKMVP YLHSDSTYKI KIHTFNKTLT
130 140 150 160 170 180
QEEKVKRIDA LEFLPFQGKV NLKKPQHVFS ILEDYGLDPN SIPKDPHNIY FGRWIADGQR
190 200 210 220 230 240
ELIESYSVKK RHFIGNTSMD AGLSFIMTNH AKVKENDLVF DPFVGTGGLL IASAHFGAYV
250 260 270 280 290 300
CGTDIDYNTV HGLGKASRKN QKWRGPDENI RANLRQYGLE KFYLDVLVSD ASKPSWRKGT
310 320 330 340 350 360
YFDAIITDPP YGIRESTRRS GSQKDIPKGI EKCPESHVPV SLSYHLSDMF FDLLNFAAET
370 380 390 400 410 420
LVLGGRLVYW LPVYTPEYTE EMVPWHPCLR LISNCEQKLS SHTARRLITM EKVKEFENRD
430 440 450
KYSHLLSDHF LPYQGHNSFR EKYFSGVTKR IAKEEKCSHE