Q12463

PR
Gene name
TRM11 (YOL124C)
Protein name
tRNA (guanine(10)-N2)-methyltransferase
Names
tRNA [Gm10] methyltransferase, tRNA guanosine-2'-O-methyltransferase TRM11, tRNA methylase 11
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YOL124C
EC number
2.1.1.214: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

52-121 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q12463

Entry ID Method Resolution Chain Position Source
AF-Q12463-F1 Predicted AlphaFoldDB

8 variants for Q12463

Variant ID(s) Position Change Description Diseaes Association Provenance
s15-86504 85 R>H No SGRP
s15-86462 99 H>L No SGRP
s15-86434 108 C>W No SGRP
s15-86295 155 V>F No SGRP
s15-86085 225 V>I No SGRP
s15-85809 317 M>V No SGRP
s15-85688 357 G>D No SGRP
s15-85524 412 S>P No SGRP

No associated diseases with Q12463

2 regional properties for Q12463

Type Name Position InterPro Accession
domain Ribosomal RNA large subunit methyltransferase K/L-like, FLD domain 184 - 297 IPR000241
conserved_site DNA methylase, N-6 adenine-specific, conserved site 288 - 294 IPR002052

Functions

Description
EC Number 2.1.1.214 Methyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
tRNA (m2G10) methyltransferase complex A protein complex required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNA. In S. cerevisiae, this complex consists of at least two subunits, Trm11p and Trm112p.

3 GO annotations of molecular function

Name Definition
methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule.
tRNA (guanine-N2-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing guanine = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine.
tRNA binding Binding to a transfer RNA.

2 GO annotations of biological process

Name Definition
tRNA methylation The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule.
tRNA modification The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q6YJI5 TRMT11 tRNA (guanine(10)-N2)-methyltransferase homolog Gallus gallus (Chicken) PR
Q9CWH5 Trmt11 tRNA (guanine(10)-N2)-methyltransferase homolog Mus musculus (Mouse) PR
10 20 30 40 50 60
MKKYLLYMVQ VHLNFRRAEL ESLADLYNLS IDFSQYDANS PFFIVELEND QQAKDWIKRS
70 80 90 100 110 120
ILTRGIYEYW GQGTTLDELH KDIQRQSNFE QDLQLKFKHS TFKFEFECYK GNSKAKRVEQ
130 140 150 160 170 180
IETFRYLGFE GKIDMKHPQE VFTVIEEYTP ISENVGGKTP TRIYFGRQVQ MSNRSAMEKY
190 200 210 220 230 240
DLKKRPYKGT TSFEAELSLV SANIAQVKPG TIMYDPFAGT GSFLVAGGHF GSLVIGSDID
250 260 270 280 290 300
GRMIRGKGAQ VNISANFKKY GESSQFLDVL TMDFTNNALR NNLVIDTILC DPPYGIRESI
310 320 330 340 350 360
KVLGAKDPER FLGKEDMEID GEKAYLRRDY IPTKKPYALD SLLDDLLQYS SERLPIGGRL
370 380 390 400 410 420
AFWMPTANDA NIETIVPMHE NLELKYNCVQ EFNKWSRRLL VYINRGSTFN GSSNHGIKRS
430
KDNFRERYFN NFN