Q9CR59

PR
Gene name
Gadd45gip1 (Mrpl59)
Protein name
Growth arrest and DNA damage-inducible proteins-interacting protein 1
Names
39S ribosomal protein L59, mitochondrial, MRP-L59
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:102060
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-222 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9CR59

Entry ID Method Resolution Chain Position Source
AF-Q9CR59-F1 Predicted AlphaFoldDB

8 variants for Q9CR59

Variant ID(s) Position Change Description Diseaes Association Provenance
rs50271456 19 G>S No EVA
rs33181488 71 P>L No EVA
rs3399369364 77 P>L No EVA
rs3398447532 104 R>Q No EVA
rs3389001304 142 R>C No EVA
rs3388994272 181 D>V No EVA
rs3389001319 208 S>F No EVA
rs51467123 209 A>V No EVA

No associated diseases with Q9CR59

No regional properties for Q9CR59

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9CR59

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion
  • Nucleus
  • Using N-terminally tagged constructs, has been found in the nucleus
  • C-terminally tagged constructs are targeted exclusively to mitochondria
  • This discrepancy may be explained by masking of a potential N-terminal mitochondrial targeting signal by the tag
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial large ribosomal subunit The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
mitochondrial translation The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8TAE8 GADD45GIP1 Growth arrest and DNA damage-inducible proteins-interacting protein 1 Homo sapiens (Human) PR
Q5XJW2 Gadd45gip1 Growth arrest and DNA damage-inducible proteins-interacting protein 1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MAALAMRSGY LLRLSVALGP RSRSYRAPPP PRRRPGPHSP DPENLLTPRW QLTPRYVAKQ
70 80 90 100 110 120
FGRHGAISGV PPASLWPTPE QLRELEAEEQ EWYPSLATMQ ESLRLQQQAL EARRQAREQR
130 140 150 160 170 180
IAECMAKMPQ MIENWRKQKR ERWEKIQADK ERRARLQAEA QERLGYHVDP RSARFQELLQ
190 200 210 220
DLDKQQRKRL KEERQRQKKE ARIAAMASAE AQDSAVSGEP SS