Q9CQE0

PR
Gene name
Rnf138
Protein name
E3 ubiquitin-protein ligase RNF138
Names
RING finger protein 138, RING-type E3 ubiquitin transferase RNF138
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:56515
EC number
2.3.2.27: Aminoacyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

82-175 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9CQE0

Entry ID Method Resolution Chain Position Source
AF-Q9CQE0-F1 Predicted AlphaFoldDB

3 variants for Q9CQE0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3408352009 44 L>P No EVA
rs3408287814 101 H>L No EVA
rs3389490828 225 L>F No EVA

No associated diseases with Q9CQE0

4 regional properties for Q9CQE0

Type Name Position InterPro Accession
domain Zinc finger, RING-type 18 - 58 IPR001841-1
domain Zinc finger, RING-type 159 - 192 IPR001841-2
domain Drought induced 19 protein type, zinc-binding domain 156 - 216 IPR008598
domain Zinc finger C2HC RNF-type 80 - 112 IPR034734

Functions

Description
EC Number 2.3.2.27 Aminoacyltransferases
Subcellular Localization
  • Chromosome
  • Recruited at DNA damage sites
  • Localizes to sites of double-strand break: localization to double-strand break sites is mediated by the zinc fingers
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
site of double-strand break A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.

4 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
single-stranded DNA binding Binding to single-stranded DNA.
ubiquitin protein ligase activity Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.

5 GO annotations of biological process

Name Definition
cellular response to leukemia inhibitory factor Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus.
DNA double-strand break processing involved in repair via single-strand annealing The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang that results in the repair of a double strand break via single-strand annealing.
double-strand break repair via homologous recombination The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.
protein ubiquitination The process in which one or more ubiquitin groups are added to a protein.
Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8WVD3 RNF138 E3 ubiquitin-protein ligase RNF138 Homo sapiens (Human) PR
10 20 30 40 50 60
MSEELSAATS YTEDDFYCPV CQEVLKTPVR TAACQHVFCR KCFLTAMRES GIHCPLCRGS
70 80 90 100 110 120
VTRRERACPE RALDLENIMR RFSGSCRCCS KKIKFYRMRH HYKSCKKYQD EYGVSSVIPN
130 140 150 160 170 180
FKISQDSVRS SNRSETSASD NTETYQEDTS SSGHPTFKCP LCQESNFTRQ RLLDHCNSNH
190 200 210 220 230 240
LFQIVPVTCP ICVSLPWGDP SQITRNFVSH LNQRHQFDYG EFVNLQLDEE TQYQTAVEES
FQVNM