AiPD: Autoinhibited Protein Database

Q8WVD3

Gene name	RNF138
Protein name	E3 ubiquitin-protein ligase RNF138
Names	Nemo-like kinase-associated RING finger protein, NLK-associated RING finger protein, hNARF, RING finger protein 138, RING-type E3 ubiquitin transferase RNF138
Species	Homo sapiens (Human)
KEGG Pathway	hsa:51444
EC number	2.3.2.27: Aminoacyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

78-165 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

78-165 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q8WVD3

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8WVD3-F1	Predicted				AlphaFoldDB

117 variants for Q8WVD3

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA402255445 rs1399475410	2	A>V		No	ClinGen gnomAD
CA8930616 rs768736694	3	E>A		No	ClinGen ExAC gnomAD
CA8930617 rs116403100	3	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8930615 rs768736694	3	E>G		No	ClinGen ExAC gnomAD
CA402255447 rs1289349465	3	E>K		No	ClinGen TOPMed
CA402255455 rs1341861985	4	D>A		No	ClinGen gnomAD
CA298319553 rs552128671	5	L>F		No	ClinGen 1000Genomes TOPMed
CA402255462 rs1398614699	5	L>H		No	ClinGen gnomAD
CA8930618 rs770913259	6	S>C		No	ClinGen ExAC gnomAD
rs1326281405 CA402255474	7	A>V		No	ClinGen gnomAD
CA8930619 rs776550133	8	A>S		No	ClinGen ExAC TOPMed gnomAD
CA402255492 rs1254717414	10	S>F		No	ClinGen gnomAD
rs764761557 CA8930621	11	Y>C		No	ClinGen ExAC gnomAD
rs1445480537 CA402255505	12	T>I		No	ClinGen TOPMed gnomAD
CA298319554 rs971442195	14	D>V		No	ClinGen Ensembl
CA402255522 rs1262208209	15	D>H		No	ClinGen gnomAD
CA8930623 rs762391892	20	V>I		No	ClinGen ExAC gnomAD
CA8930626 rs757749867	26	K>R		No	ClinGen ExAC gnomAD
CA298319556 rs927403921	27	T>R		No	ClinGen gnomAD
TCGA novel	29	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8930630 rs780166210	32	T>A		No	ClinGen ExAC TOPMed gnomAD
CA402255635 rs780166210	32	T>S		No	ClinGen ExAC TOPMed gnomAD
rs1193003840 CA402255645	33	A>V		No	ClinGen TOPMed
TCGA novel	35	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA402255661 rs1568220269	35	Q>H		No	ClinGen Ensembl
CA402255654 rs1487578116	35	Q>K		No	ClinGen TOPMed
CA402255658 rs1264931099	35	Q>R		No	ClinGen TOPMed
rs1351514733 CA402255670	37	V>F		No	ClinGen gnomAD
rs758508871 CA8930655	47	M>I		No	ClinGen ExAC TOPMed gnomAD
rs748204194 CA8930654	47	M>V		No	ClinGen ExAC TOPMed gnomAD
CA8930656 rs781300995	48	R>K		No	ClinGen ExAC gnomAD
CA402255775 rs1315971206	50	S>G		No	ClinGen gnomAD
rs775349440 CA8930659	51	G>R		No	ClinGen ExAC gnomAD
rs1481305138 CA402255791	52	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs768267760 CA8930661	53	H>R		No	ClinGen ExAC gnomAD
rs1422182371 CA402255829	58	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1370502566 CA402255844	60	N>S		No	ClinGen TOPMed
CA298321934 rs754554442	63	R>I		No	ClinGen TOPMed gnomAD
TCGA novel	67	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA402255916 rs1363216536	71	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1402590553 CA402255921	72	A>S		No	ClinGen gnomAD
TCGA novel	74	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1175427545 CA402255943	75	L>F		No	ClinGen gnomAD
CA8930663 rs761336148	76	E>Q		No	ClinGen ExAC gnomAD
CA8930664 rs766960918	77	N>Y		No	ClinGen ExAC TOPMed gnomAD
CA8930667 rs200018900	78	I>V		No	ClinGen 1000Genomes ExAC gnomAD
CA402255978 rs1315758650	80	R>K		No	ClinGen gnomAD
rs7229690 CA8930668 VAR_052109	81	K>R		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs766714253 CA8930669	82	F>L		No	ClinGen ExAC gnomAD
TCGA novel	84	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	91	K>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA402256069 rs1483366182	92	Q>H		No	ClinGen gnomAD
rs771639268 CA8930688	95	F>L		No	ClinGen ExAC gnomAD
rs747736592 CA8930686	95	F>Y		No	ClinGen ExAC TOPMed gnomAD
rs761132854 CA8930689	96	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA402256113 rs1455606551	97	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs771435681 CA8930690	97	R>H		No	ClinGen ExAC TOPMed gnomAD
CA402256205 rs1418941462	109	Q>P		No	ClinGen gnomAD
rs1318713318 CA402256210	110	D>N		No	ClinGen gnomAD
CA298322110 rs200800390	117	I>V		No	ClinGen gnomAD
CA402256265 rs1306686290	118	I>V		No	ClinGen gnomAD
rs1352506409 CA402256279	120	N>Y		No	ClinGen gnomAD
rs763261761 CA8930695	122	Q>H		No	ClinGen ExAC gnomAD
rs764136681 CA8930696	123	I>V		No	ClinGen ExAC gnomAD
CA8930700 rs753660399	126	D>G		No	ClinGen ExAC gnomAD
CA8930699 rs780062639	126	D>H		No	ClinGen ExAC TOPMed gnomAD
CA8930701 rs754775307	127	S>A		No	ClinGen ExAC gnomAD
rs1009524449 CA298322111	129	G>A		No	ClinGen TOPMed
CA8930702 rs778679208	130	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA298323221 rs76178144	131	S>R		No	ClinGen Ensembl
rs1330533554 CA402256376	133	R>G		No	ClinGen gnomAD
rs1338322894 CA402256379	133	R>T		No	ClinGen gnomAD
CA298323222 rs78071298	135	E>K		No	ClinGen Ensembl
rs1327006694 CA402256407	137	S>F		No	ClinGen Ensembl
rs1294294734 CA402256411	138	T>A		No	ClinGen gnomAD
rs1357692531 CA402256428	140	D>E		No	ClinGen TOPMed gnomAD
CA402256457 rs1217358916	144	T>I		No	ClinGen TOPMed gnomAD
TCGA novel	144	T>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA402256463 rs1555699737	145	Y>F		No	ClinGen Ensembl
CA298323223 rs1040860551	147	E>D		No	ClinGen TOPMed gnomAD
CA402256490 rs1318740748	149	T>A		No	ClinGen gnomAD
rs1211908053 CA402256518	151	S>F		No	ClinGen gnomAD
rs1282702998 CA402256529	153	G>D		No	ClinGen gnomAD
TCGA novel	155	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA402256547 rs1275655873	156	T>A		No	ClinGen TOPMed
TCGA novel	165	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs772660133 CA298323334	168	T>I		No	ClinGen Ensembl
COSM987714 CA8930742 rs759513121	171	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs554701391 CA8930743	171	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs752580212 CA8930744	174	D>A		No	ClinGen ExAC gnomAD
CA298323335 rs914673896	181	L>R		No	ClinGen Ensembl
rs1477384304 CA402256742	183	Q>H		No	ClinGen gnomAD
CA298323336 rs968861963	184	I>T		No	ClinGen gnomAD
CA402256761 rs1481844928	186	P>L		No	ClinGen gnomAD
TCGA novel	186	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1173920254 CA402256764	187	V>L		No	ClinGen gnomAD
rs1246796336 CA402256794	190	P>A		No	ClinGen TOPMed
rs369606904 CA8930756	193	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs780720605 CA8930755	193	V>M		No	ClinGen ExAC gnomAD
TCGA novel	196	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs971419660 CA298323530	197	W>G		No	ClinGen TOPMed
CA8930758 rs779136044	199	D>N		No	ClinGen ExAC gnomAD
CA402256864 rs1364774010	200	P>S		No	ClinGen gnomAD
rs1309524763 CA402256932	208	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA402256943 rs1390633384	209	S>T		No	ClinGen gnomAD
TCGA novel	213	Q>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	217	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA402257018 rs1328011069	218	D>E		No	ClinGen gnomAD
CA402257072 rs1310311957	224	N>S		No	ClinGen TOPMed gnomAD
CA298323813 rs111517421	226	Q>R		No	ClinGen Ensembl
rs1182230646 CA402257095	228	D>H		No	ClinGen TOPMed
rs777981886 CA8930778	233	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs1274943635 CA402257143	234	Q>R		No	ClinGen gnomAD
rs747164148 CA8930779	235	T>I		No	ClinGen ExAC gnomAD
CA8930780 rs771064744	239	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA402257189 rs1203194550	241	F>S		No	ClinGen gnomAD
rs1251598383 CA402257216	245	I>V		No	ClinGen gnomAD

No associated diseases with Q8WVD3

1 regional properties for Q8WVD3

Type	Name	Position	InterPro Accession
domain	HemY, N-terminal	27 - 116	IPR010817

Functions

		Description
EC Number	2.3.2.27	Aminoacyltransferases
Subcellular Localization	Chromosome	Recruited at DNA damage sites (PubMed:26502055) Localizes to sites of double-strand break: localization to double-strand break sites is mediated by the zinc fingers (PubMed:26502055, PubMed:26502057)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
site of double-strand break	A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.

4 GO annotations of molecular function

Name	Definition
metal ion binding	Binding to a metal ion.
protein kinase binding	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
single-stranded DNA binding	Binding to single-stranded DNA.
ubiquitin protein ligase activity	Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.

4 GO annotations of biological process

Name	Definition
DNA double-strand break processing involved in repair via single-strand annealing	The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang that results in the repair of a double strand break via single-strand annealing.
double-strand break repair via homologous recombination	The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.
protein ubiquitination	The process in which one or more ubiquitin groups are added to a protein.
Wnt signaling pathway	The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9CQE0	Rnf138	E3 ubiquitin-protein ligase RNF138	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MAEDLSAATS	YTEDDFYCPV	CQEVLKTPVR	TTACQHVFCR	KCFLTAMRES	GAHCPLCRGN
70	80	90	100	110	120
VTRRERACPE	RALDLENIMR	KFSGSCRCCA	KQIKFYRMRH	HYKSCKKYQD	EYGVSSIIPN
130	140	150	160	170	180
FQISQDSVGN	SNRSETSTSD	NTETYQENTS	SSGHPTFKCP	LCQESNFTRQ	RLLDHCNSNH
190	200	210	220	230	240
LFQIVPVTCP	ICVSLPWGDP	SQITRNFVSH	LNQRHQFDYG	EFVNLQLDEE	TQYQTAVEES

FQVNI