Q9CPV5

PR
Gene name
Pmf1
Protein name
Polyamine-modulated factor 1
Names
PMF-1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:67037
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-55 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9CPV5

Entry ID Method Resolution Chain Position Source
AF-Q9CPV5-F1 Predicted AlphaFoldDB

15 variants for Q9CPV5

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388643195 13 R>G No EVA
rs3388621884 37 A>T No EVA
rs32889020 52 Y>F No EVA
rs3388643768 85 I>T No EVA
rs3388632394 93 K>* No EVA
rs3388630002 111 E>K No EVA
rs32888348 112 G>D No EVA
rs32888345 115 R>H No EVA
rs3388639916 119 A>V No EVA
rs3388643791 167 R>C No EVA
rs3388630032 167 R>E No EVA
rs3388632370 170 V>G No EVA
rs3388632316 170 V>L No EVA
rs237964105 176 Q>E No EVA
rs1132511244 200 A>T No EVA

No associated diseases with Q9CPV5

No regional properties for Q9CPV5

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9CPV5

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Chromosome, centromere, kinetochore
  • Associated with the kinetochore
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
kinetochore A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
MIS12/MIND type complex A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans, it consists of MIS12, DSN1, NSL1 and PMF1.
NMS complex A supercomplex formed by the association of two subcomplexes (known as MIND and Ndc80 in Schizosaccharomyces) with additional proteins at the kinetochores of condensed nuclear chromosomes.
nuclear MIS12/MIND complex A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore of a chromosome in the nucleus. It helps to recruit outer kinetochore subunits that will bind to microtubules. Nuclear localization arises in some organisms because the nuclear envelope is not broken down during mitosis. In S. cerevisiae, it consists of at least four proteins: Mtw1p, Nnf1p, Nsl1p, and Dsn1.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

2 GO annotations of molecular function

Name Definition
leucine zipper domain binding Binding to a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns.
transcription coactivator activity A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator.

3 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
chromosome segregation The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q6P1K2 PMF1 Polyamine-modulated factor 1 Homo sapiens (Human) PR
10 20 30 40 50 60
MAEVSRDSEA AERGPEGSSP EAVPGDATIP RVKLLDAIVD TFLQKLVADR SYERFTTCYK
70 80 90 100 110 120
HFHQLNPEVT QRIYDKFVAQ LQTSIREEIS EIKEEGNLEA VLNSLDKIIE EGRERGEPAW
130 140 150 160 170 180
RPSGIPEKDL CSVMAPYFLK QQDTLCHQVR KQEAKNQELA DAVLAGRRQV EELQQQVRAL
190 200
QQTWQALHRE QRELLSVLRA PE