AiPD: Autoinhibited Protein Database

Q6P1K2

Gene name	PMF1
Protein name	Polyamine-modulated factor 1
Names	PMF-1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:11243
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-55 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-55 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for Q6P1K2

Entry ID	Method	Resolution	Chain	Position	Source
5LSJ	X-ray	325 A	B/E	31-205	PDB
5LSK	X-ray	350 A	B	31-205	PDB
8Q5H	EM	450 A	B	1-205	PDB
AF-Q6P1K2-F1	Predicted				AlphaFoldDB

192 variants for Q6P1K2

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA1155777 rs777939436	2	A>D		No	ClinGen ExAC gnomAD
CA1155778 rs749848175	3	E>G		No	ClinGen ExAC gnomAD
rs767498512 CA31035159	4	A>E		No	ClinGen TOPMed gnomAD
rs146867902 CA1155779	4	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs767498512 CA342831754	4	A>V		No	ClinGen TOPMed gnomAD
rs1474510250 CA342831803	6	S>G		No	ClinGen TOPMed
rs778448047 CA1155782	6	S>I		No	ClinGen ExAC TOPMed gnomAD
rs778448047 CA1155780	6	S>N		No	ClinGen ExAC TOPMed gnomAD
rs778448047 CA1155781	6	S>T		No	ClinGen ExAC TOPMed gnomAD
rs775216061 CA1155783	8	N>H		No	ClinGen ExAC TOPMed gnomAD
CA342831873 rs1382705777	8	N>K		No	ClinGen gnomAD
CA1155784 rs746586716	11	S>G		No	ClinGen ExAC gnomAD
rs1353582802 CA342831923	11	S>N		No	ClinGen gnomAD
CA342831932 rs1414253839	11	S>R		No	ClinGen gnomAD
rs1558186229 CA342831954	12	G>A		No	ClinGen Ensembl
CA1155785 rs768555004	12	G>C		No	ClinGen ExAC TOPMed gnomAD
CA342831978 rs1237224129	13	C>F		No	ClinGen TOPMed gnomAD
rs377730230 CA1155786	13	C>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs201504927 CA1155787	13	C>W		No	ClinGen ExAC gnomAD
CA342831972 rs1237224129	13	C>Y		No	ClinGen TOPMed gnomAD
rs201900663 CA31035222	14	E>G		No	ClinGen gnomAD
CA1155789 rs773234191	15	E>G		No	ClinGen ExAC gnomAD
rs1001667083 CA31035248	17	R>T		No	ClinGen Ensembl
CA342832108 rs1256304903	18	H>P		No	ClinGen gnomAD
rs1370706308 CA342832117	19	E>K		No	ClinGen TOPMed
CA342832163 rs1449576325	20	G>E		No	ClinGen TOPMed
CA1155792 rs752974319	20	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1572471692 CA342832189	21	S>A		No	ClinGen Ensembl
rs764581905 CA1155794	21	S>L		No	ClinGen ExAC TOPMed gnomAD
rs995807995 CA31035276	22	S>F		No	ClinGen Ensembl
CA1155797 rs146208639	24	E>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA1155798 rs746310331	25	S>P		No	ClinGen ExAC gnomAD
CA31035329 rs765440844	26	V>M		No	ClinGen Ensembl
rs1389889375 CA342832324	27	P>L		No	ClinGen TOPMed gnomAD
CA342832311 rs1381486325	27	P>S		No	ClinGen gnomAD
CA342832314 rs1381486325	27	P>T		No	ClinGen gnomAD
rs779418661 CA1155801	28	P>H		No	ClinGen ExAC TOPMed gnomAD
rs779418661 CA1155800	28	P>R		No	ClinGen ExAC TOPMed gnomAD
rs757941220 CA1155799	28	P>T		No	ClinGen ExAC gnomAD
CA1155803 rs776537237	29	G>C		No	ClinGen ExAC gnomAD
CA1155804 rs200909305	29	G>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA342832374 rs1212275118	30	T>A		No	ClinGen gnomAD
CA342832409 rs1483980342	31	T>I		No	ClinGen gnomAD
rs769670305 CA1155805	32	I>S		No	ClinGen ExAC gnomAD
CA342832438 rs1201769847	33	S>A		No	ClinGen TOPMed
rs773285630 CA1155806	37	L>F		No	ClinGen ExAC TOPMed gnomAD
CA31035426 rs758510947	38	L>F		No	ClinGen Ensembl
rs762922221 CA1155807	40	T>I		No	ClinGen ExAC gnomAD
rs1345305369 CA342832571	41	M>K		No	ClinGen TOPMed
rs1176793557 CA342832580	42	V>L		No	ClinGen gnomAD
CA1155810 rs767691638	45	F>S		No	ClinGen ExAC gnomAD
rs772185695	45	F>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA1155811 rs775423643	46	L>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA342832642 rs1324263311	47	Q>K		No	ClinGen gnomAD
CA1155813 rs564773343	48	K>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA342832670 rs1304069342	49	L>V		No	ClinGen gnomAD
rs377154093 CA1155816	52	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs377154093 CA1155817	52	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs750988132 CA1155818	53	G>S		No	ClinGen ExAC TOPMed
rs758828671 CA1155819	54	S>N		No	ClinGen ExAC gnomAD
CA342836923 rs1386414799	56	Q>E		No	ClinGen gnomAD
TCGA novel	56	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1155883 rs756934419	58	F>L		No	ClinGen ExAC gnomAD
rs1042744406 CA31050158	60	D>G		No	ClinGen TOPMed
CA1155884 rs764982739	61	C>F		No	ClinGen ExAC gnomAD
CA31050163 rs764982739	61	C>Y		No	ClinGen ExAC gnomAD
rs1333096573 CA342837025	62	Y>C		No	ClinGen gnomAD
CA1155886 rs147468189	65	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs756196951 CA1155890	71	A>G		No	ClinGen ExAC TOPMed gnomAD
CA1155889 rs756196951	71	A>V		No	ClinGen ExAC TOPMed gnomAD
CA1155891 rs749539268	72	M>I		No	ClinGen ExAC gnomAD
CA342837218 rs1425372371	72	M>K		No	ClinGen TOPMed gnomAD
CA342837220 rs1425372371	72	M>T		No	ClinGen TOPMed gnomAD
rs945773581 CA31050254	73	T>A		No	ClinGen Ensembl
CA342837242 rs1190784458	74	Q>*		No	ClinGen TOPMed
CA1155893 rs1052053	75	Q>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1155892 rs1052053 VAR_034147	75	Q>R		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA342837284 rs1258650400	77	Y>C		No	ClinGen gnomAD
rs1407001469 CA342837298	78	D>A		No	ClinGen gnomAD
CA342837348 rs1339850190	81	I>M		No	ClinGen TOPMed gnomAD
rs907005503 CA31050258	82	A>V		No	ClinGen Ensembl
rs1400721909 CA342837374	84	L>M		No	ClinGen gnomAD
CA342837391 rs1280293649	85	Q>*		No	ClinGen gnomAD
CA342837419 rs532329234	87	S>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs772522149 CA1155895	87	S>P		No	ClinGen ExAC gnomAD
CA1155896 rs532329234	87	S>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs773324194 CA1155898	89	R>Q		No	ClinGen ExAC gnomAD
rs150630684 CA1155897	89	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA342837447 rs1465617335	90	E>D		No	ClinGen gnomAD
rs1558196153 CA342837449	91	E>K		No	ClinGen Ensembl
CA342837477 rs1303591719	94	D>E		No	ClinGen gnomAD
rs762578734 CA1155920	95	I>V		No	ClinGen ExAC gnomAD
rs1572502384 CA342837485	96	K>E		No	ClinGen Ensembl
CA1155922 rs149817565	99	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA1155924 rs767507954	100	N>Y		No	ClinGen ExAC gnomAD
CA31051287 rs971132932	101	L>V		No	ClinGen TOPMed
CA31051294 rs752534455 COSM897142	102	E>*	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA1155925 rs752534455	102	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA31051298 rs11548876	103	A>V		No	ClinGen Ensembl
CA342837539 rs1309885401	104	V>A		No	ClinGen gnomAD
rs757360180 CA1155926	107	A>S		No	ClinGen ExAC gnomAD
TCGA novel	110	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA342837605 rs1200001096	114	E>K		No	ClinGen Ensembl
CA342837617 rs1196437202	115	G>A		No	ClinGen gnomAD
rs1196437202 CA342837618	115	G>V		No	ClinGen gnomAD
rs750744751 CA1155928	116	K>E		No	ClinGen ExAC gnomAD
rs758667378 CA1155929	118	R>C		No	ClinGen ExAC TOPMed gnomAD
rs141326392 CA1155930	118	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs369423554 CA1155933	120	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs377059409 CA1155932	120	E>K		No	ClinGen ESP ExAC gnomAD
rs748544819 CA1155934	122	A>T		No	ClinGen ExAC gnomAD
rs771971437 CA1155959 COSM675670	124	R>C	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA342839397 rs1487327435	124	R>H		No	ClinGen gnomAD
rs1229804115 CA342839414	125	P>S		No	ClinGen TOPMed
CA342839434 rs1264057676	126	S>T		No	ClinGen gnomAD
CA1155962 rs766235404	127	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1006626784 CA31053363	128	I>F		No	ClinGen TOPMed
rs1405159530 CA342839484	129	P>A		No	ClinGen TOPMed gnomAD
rs1163067794 CA342839494	129	P>L		No	ClinGen TOPMed gnomAD
rs1405159530 CA342839481	129	P>T		No	ClinGen TOPMed gnomAD
CA342839510 rs1167465484	130	E>G		No	ClinGen gnomAD
rs763130134 CA1155964	131	K>E		No	ClinGen ExAC TOPMed gnomAD
CA342839564 rs1297012800	132	D>E		No	ClinGen gnomAD
CA1155965 rs766510624	132	D>G		No	ClinGen ExAC TOPMed gnomAD
rs1044925132 CA31053378	134	H>Y		No	ClinGen TOPMed
CA1155966 rs751868897	135	S>G		No	ClinGen ExAC TOPMed gnomAD
CA342839594 rs751868897	135	S>R		No	ClinGen ExAC TOPMed gnomAD
CA342839608 rs1558197641	136	V>I		No	ClinGen Ensembl
CA1155969 rs1052067 VAR_034148	137	M>I		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs767964139 CA1155968	137	M>T		No	ClinGen ExAC TOPMed gnomAD
CA1155967 rs146023155	137	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA1155970 rs555212220	138	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs778280527 CA1155971	140	Y>D		No	ClinGen ExAC gnomAD
rs1239408709 CA342839701	143	Q>*		No	ClinGen TOPMed gnomAD
CA31053416 rs1031004715	144	Q>H		No	ClinGen TOPMed gnomAD
CA1155972 rs573328595	144	Q>K		No	ClinGen 1000Genomes ExAC gnomAD
CA1155974 rs778285141	145	R>Q		No	ClinGen ExAC gnomAD
CA1155973 rs149553436	145	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs62001898 CA1155977	149	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1155976 rs140410413	149	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs62001899 CA1155978	150	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs768500887 CA1155979	150	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs371184439 CA1155980	151	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1329327337 CA342839917	153	Q>H		No	ClinGen TOPMed
TCGA novel	154	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1331747405 CA342839921	154	K>Q		No	ClinGen gnomAD
CA31053465 rs374332989	154	K>R		No	ClinGen ESP TOPMed
rs1410082687 CA342839936	155	Q>*		No	ClinGen TOPMed
CA1155981 rs761830699	156	E>G		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	157	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1155985 rs767655347	158	E>K		No	ClinGen ExAC TOPMed gnomAD
CA342839987 rs1445871536	158	E>V		No	ClinGen gnomAD
CA1155986 rs148649401	159	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs761027917 CA1155987	160	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA1155988 rs764380670	160	Q>R		No	ClinGen ExAC gnomAD
COSM463146 CA342840055 rs1205873320	165	A>V	kidney [Cosmic]	No	ClinGen cosmic curated gnomAD
rs141293459 CA1155991	166	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1170275332 CA342840094	170	R>Q		No	ClinGen gnomAD
CA1155993 rs548726372	170	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA1155995 rs367865962	172	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1572506653 CA342840119	173	V>G		No	ClinGen Ensembl
CA342840114 rs1178149427	173	V>M		No	ClinGen gnomAD
rs1572506659 CA342840128	174	E>G		No	ClinGen Ensembl
rs370310915 CA1155998	175	E>D		No	ClinGen ESP ExAC gnomAD
rs1233377219 CA342840149	177	Q>*		No	ClinGen TOPMed
CA1155999 rs769830916	178	L>I		No	ClinGen ExAC gnomAD
CA342840165 rs1331904881	179	Q>*		No	ClinGen gnomAD
CA1156000 rs773153057	179	Q>R		No	ClinGen ExAC gnomAD
CA342840171 rs180708431	180	V>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1572506730 CA342840175	180	V>G		No	ClinGen Ensembl
rs180708431 CA1156001	180	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs772118740 CA1156002	181	Q>*		No	ClinGen ExAC gnomAD
rs528319714 CA1156003	182	A>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1156005 rs764484778	184	Q>H		No	ClinGen ExAC gnomAD
CA31053570 rs1030430623	184	Q>P		No	ClinGen TOPMed gnomAD
rs754182108 CA1156006	185	Q>*		No	ClinGen ExAC
rs917756111 CA31053582	188	Q>*		No	ClinGen TOPMed
CA31001575 rs202060317	189	A>P		No	ClinGen gnomAD
CA342816151 rs202060317	189	A>T		No	ClinGen gnomAD
CA31001588 rs769669279	193	E>A		No	ClinGen TOPMed gnomAD
rs747282929 CA1156025	193	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1374510120 CA342816260	194	Q>R		No	ClinGen gnomAD
TCGA novel	195	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768891606 CA1156026	199	A>T		No	ClinGen ExAC gnomAD
CA31001606 rs984804277	200	V>M		No	ClinGen Ensembl
rs551755441 CA1156027	201	L>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs570064124 CA1156028	202	R>K		No	ClinGen 1000Genomes ExAC gnomAD
CA31001625 rs1045059204	203	E>D		No	ClinGen TOPMed gnomAD
rs765580235 CA1156029	204	P>A		No	ClinGen ExAC TOPMed gnomAD
CA1156030 rs765580235	204	P>S		No	ClinGen ExAC TOPMed gnomAD
CA1156032 rs765849095	205	E>D		No	ClinGen ExAC gnomAD
CA1156031 rs763512993	205	E>K		No	ClinGen ExAC TOPMed gnomAD

No associated diseases with Q6P1K2

3 regional properties for Q6P1K2

Type	Name	Position	InterPro Accession
binding_site	Peptidase M16, zinc-binding site	88 - 111	IPR001431
domain	Peptidase M16, C-terminal	220 - 404	IPR007863
domain	Peptidase M16, N-terminal	68 - 214	IPR011765

Functions

		Description
EC Number
Subcellular Localization	Nucleus Chromosome, centromere, kinetochore	Associated with the kinetochore
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

9 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
kinetochore	A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
MIS12/MIND type complex	A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans, it consists of MIS12, DSN1, NSL1 and PMF1.
NMS complex	A supercomplex formed by the association of two subcomplexes (known as MIND and Ndc80 in Schizosaccharomyces) with additional proteins at the kinetochores of condensed nuclear chromosomes.
nuclear MIS12/MIND complex	A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore of a chromosome in the nucleus. It helps to recruit outer kinetochore subunits that will bind to microtubules. Nuclear localization arises in some organisms because the nuclear envelope is not broken down during mitosis. In S. cerevisiae, it consists of at least four proteins: Mtw1p, Nnf1p, Nsl1p, and Dsn1.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
transcription regulator complex	A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.

2 GO annotations of molecular function

Name	Definition
leucine zipper domain binding	Binding to a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns.
transcription coactivator activity	A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator.

4 GO annotations of biological process

Name	Definition
cell cycle	The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
chromosome segregation	The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
transcription by RNA polymerase II	The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9CPV5	Pmf1	Polyamine-modulated factor 1	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MAEASSANLG	SGCEEKRHEG	SSSESVPPGT	TISRVKLLDT	MVDTFLQKLV	AAGSYQRFTD
70	80	90	100	110	120
CYKCFYQLQP	AMTQQIYDKF	IAQLQTSIRE	EISDIKEEGN	LEAVLNALDK	IVEEGKVRKE
130	140	150	160	170	180
PAWRPSGIPE	KDLHSVMAPY	FLQQRDTLRR	HVQKQEAENQ	QLADAVLAGR	RQVEELQLQV
190	200
QAQQQAWQAL	HREQRELVAV	LREPE