Q9BYV8
PR
Gene name |
CEP41 (TSGA14) |
Protein name |
Centrosomal protein of 41 kDa |
Names |
Cep41, Testis-specific gene A14 protein |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:95681 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9BYV8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9BYV8-F1 | Predicted | AlphaFoldDB |
312 variants for Q9BYV8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA4485757 RCV001041591 RCV002551499 rs782769549 |
2 | S>A | Joubert syndrome 15 Inborn genetic diseases [ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
rs782137799 RCV001060291 RCV001573282 CA4485756 |
2 | S>F | Joubert syndrome 15 [ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
rs147494464 CA4485751 RCV001567050 RCV000878049 |
7 | I>T | Joubert syndrome 15 [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
RCV001352531 CA4485747 rs149373377 |
10 | P>A | Joubert syndrome 15 [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
RCV003166643 RCV001295485 CA4485748 rs149373377 |
10 | P>T | Joubert syndrome 15 Inborn genetic diseases [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
rs1797714880 RCV001304239 |
14 | M>I | Joubert syndrome 15 [ClinVar] | Yes |
ClinVar dbSNP |
|
rs111688621 RCV003151768 CA4485715 RCV000326349 |
18 | P>L | Variant assessed as Somatic; 0.0 impact. Joubert syndrome 15 [NCI-TCGA, ClinVar] | Yes |
ClinGen ClinVar ExAC NCI-TCGA TOPMed dbSNP gnomAD |
|
CA369287167 rs1584901211 RCV000023829 |
28 | S>* | Joubert syndrome 15 (jbts15) Joubert syndrome 15 [Ensembl, ClinVar] | Yes |
ClinGen ClinVar Ensembl dbSNP |
|
RCV001544767 VAR_067053 rs368178632 RCV000023827 RCV000268974 CA129495 RCV001261715 |
36 | M>T | Joubert syndrome 15 (jbts15) Familial Autism Spectrum Disorder Joubert syndrome 9/15, digenic Joubert syndrome 15 probable disease-associated variant found in a patient with Joubert syndrome; digenic inheritance; the patient also carries a truncating mutation in CC2D2A [Ensembl, ClinVar, UniProt] | Yes |
ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
RCV001233731 rs1797355895 |
38 | K>E | Joubert syndrome 15 [ClinVar] | Yes |
ClinVar dbSNP |
|
RCV001211806 CA4485678 rs138907207 COSM389639 |
44 | E>K | lung Variant assessed as Somatic; 0.0 impact. Joubert syndrome 15 [Cosmic, NCI-TCGA, ClinVar] | Yes |
ClinGen cosmic curated ClinVar ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD |
|
rs782426353 CA4485646 RCV001317454 |
67 | A>V | Joubert syndrome 15 [ClinVar] | Yes |
ClinGen ClinVar ExAC dbSNP gnomAD |
|
RCV001045024 rs1797171250 |
76 | L>V | Joubert syndrome 15 [ClinVar] | Yes |
ClinVar dbSNP |
|
rs1797171055 RCV001316027 |
77 | S>C | Joubert syndrome 15 [ClinVar] | Yes |
ClinVar dbSNP |
|
rs1562984087 RCV000778821 CA369289874 |
82 | E>* | Joubert syndrome 15 [ClinVar] | Yes |
ClinGen ClinVar Ensembl dbSNP |
|
CA166908655 RCV001880024 rs946180222 RCV001261714 |
85 | A>P | Joubert syndrome 15 (jbts15) Familial Autism Spectrum Disorder Joubert syndrome 15 [Ensembl, ClinVar] | Yes |
ClinGen ClinVar Ensembl dbSNP |
|
CA369289462 rs1554417870 RCV001219060 |
93 | D>G | Joubert syndrome 15 [ClinVar] | Yes |
ClinGen ClinVar dbSNP gnomAD |
|
RCV001346924 rs1797169504 |
93 | D>H | Joubert syndrome 15 [ClinVar] | Yes |
ClinVar dbSNP |
|
rs200516165 RCV000322711 CA10623293 |
97 | A>T | Joubert syndrome 15 [ClinVar] | Yes |
ClinGen ClinVar dbSNP gnomAD |
|
rs141025803 RCV000224397 CA4485603 RCV000265231 RCV001261713 |
107 | A>G | Familial Autism Spectrum Disorder Joubert syndrome 15 [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
CA4485591 RCV000809209 rs782436531 |
128 | N>S | Joubert syndrome 15 [ClinVar] | Yes |
ClinGen ClinVar ExAC dbSNP gnomAD |
|
RCV000356697 rs781848162 RCV002519041 CA4485584 |
140 | Q>* | Joubert syndrome 15 [ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
RCV000498626 RCV001041906 CA4485567 rs145850728 |
144 | S>N | Joubert syndrome 15 [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
CA369288970 RCV001230486 rs1170058733 |
146 | V>A | Joubert syndrome 15 [ClinVar] | Yes |
ClinGen ClinVar TOPMed dbSNP gnomAD |
|
RCV000690921 rs1554417299 CA369288894 |
158 | K>R | Joubert syndrome 15 [ClinVar] | Yes |
ClinGen ClinVar dbSNP gnomAD |
|
RCV001229664 rs781914996 CA4485559 |
172 | P>S | Joubert syndrome 15 [ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
VAR_067055 RCV000023826 rs140259402 CA129494 COSM1448065 RCV001362438 |
179 | R>H | Variant assessed as Somatic; 0.0 impact. Joubert syndrome 12/15, digenic large_intestine Joubert syndrome 15 probable disease-associated variant found in a patient with Joubert syndrome; digenic inheritance; the patient also carries a truncating mutation in KIF7 [NCI-TCGA, ClinVar, Cosmic, UniProt] | Yes |
ClinGen cosmic curated ClinVar UniProt ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD |
|
CA4485554 RCV001302249 rs782587361 RCV003166701 |
185 | Q>E | Joubert syndrome 15 Inborn genetic diseases [ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
CA166903776 rs146662384 RCV001261712 |
201 | S>C | Familial Autism Spectrum Disorder [ClinVar] | Yes |
ClinGen ClinVar ESP dbSNP gnomAD |
|
CA4485524 RCV001880023 RCV001261711 rs782188831 |
204 | M>V | Familial Autism Spectrum Disorder Joubert syndrome 15 [ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
RCV000878420 rs143303575 RCV001702359 VAR_067056 RCV001261666 RCV000483238 CA4485523 |
206 | P>A | Familial Autism Spectrum Disorder Joubert syndrome 15 found in a patient with autism; unknown pathological significance [ClinVar, UniProt] | Yes |
ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
RCV001315916 rs1796853863 |
214 | Y>F | Joubert syndrome 15 [ClinVar] | Yes |
ClinVar dbSNP |
|
CA4485496 RCV001298862 rs527896814 |
218 | H>P | Joubert syndrome 15 [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
RCV000915939 CA4485493 rs782704307 |
227 | D>N | Joubert syndrome 15 [ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
rs1796819026 RCV001349076 |
233 | S>G | Joubert syndrome 15 [ClinVar] | Yes |
ClinVar dbSNP |
|
CA4485487 RCV001345228 rs200882016 |
239 | M>T | Joubert syndrome 15 [ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
CA152310 rs113941736 VAR_067057 RCV000116677 RCV000514927 RCV001084476 |
240 | C>G | Joubert syndrome 15 (jbts15) Joubert syndrome 15 found in a patient with autism; unknown pathological significance [Ensembl, ClinVar, UniProt] | Yes |
ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
rs1554416667 RCV001320724 CA369287800 |
242 | R>C | Joubert syndrome 15 [ClinVar] | Yes |
ClinGen ClinVar dbSNP gnomAD |
|
CA4485483 RCV001261665 RCV001880022 rs191246968 |
242 | R>H | Familial Autism Spectrum Disorder Joubert syndrome 15 [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
rs201834429 CA4485478 RCV000443886 RCV002522643 RCV001163694 |
252 | G>R | Joubert syndrome 15 Inborn genetic diseases [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
RCV001235020 CA166903005 rs1050700461 |
258 | A>V | Joubert syndrome 15 [ClinVar] | Yes |
ClinGen ClinVar TOPMed dbSNP |
|
rs200709703 RCV001050962 RCV002553243 CA4485459 COSM1085545 |
262 | P>L | Variant assessed as Somatic; 0.0 impact. endometrium Joubert syndrome 15 Inborn genetic diseases [NCI-TCGA, Cosmic, ClinVar] | Yes |
ClinGen cosmic curated ClinVar ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD |
|
rs782105300 CA4485449 RCV000426821 RCV001322686 |
284 | R>Q | Joubert syndrome 15 [ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
RCV001236338 CA166902838 rs782392521 |
304 | P>R | Joubert syndrome 15 [ClinVar] | Yes |
ClinGen ClinVar TOPMed dbSNP gnomAD |
|
rs1308536722 RCV001345414 |
310 | I>V | Joubert syndrome 15 [ClinVar] | Yes |
ClinVar dbSNP |
|
RCV000853324 rs1584867379 |
315 | E>missing | Joubert syndrome 15 [ClinVar] | Yes |
ClinVar dbSNP |
|
RCV001236772 rs782610112 RCV000722981 |
317 | E>missing | Joubert syndrome 15 [ClinVar] | Yes |
ClinVar dbSNP |
|
CA4485417 rs782286004 RCV000778820 |
326 | R>* | Variant assessed as Somatic; 0.0 impact. Joubert syndrome 15 [NCI-TCGA, ClinVar] | Yes |
ClinGen ClinVar ExAC NCI-TCGA TOPMed dbSNP gnomAD |
|
RCV003160384 RCV001049490 rs782387467 CA4485415 |
326 | R>L | Joubert syndrome 15 Inborn genetic diseases [ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
RCV001245147 CA4485416 rs782387467 |
326 | R>Q | Joubert syndrome 15 [ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
RCV000354546 CA4485413 rs368525533 RCV001261664 |
330 | A>P | Joubert syndrome 15 (jbts15) Familial Autism Spectrum Disorder Joubert syndrome 15 [Ensembl, ClinVar] | Yes |
ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD |
|
RCV001210996 rs1796760925 |
333 | S>P | Joubert syndrome 15 [ClinVar] | Yes |
ClinVar dbSNP |
|
RCV001313184 CA4485411 RCV001773624 rs564625875 |
334 | G>R | Joubert syndrome 15 (jbts15) Joubert syndrome 15 [Ensembl, ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
RCV000794924 rs782672149 CA4485410 |
335 | R>K | Joubert syndrome 15 [ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
rs147444165 CA4485409 RCV000441831 RCV001087358 |
337 | S>P | Joubert syndrome 15 [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
rs1554416156 RCV001235693 |
341 | G>D | Joubert syndrome 15 [ClinVar] | Yes |
ClinVar dbSNP |
|
CA4485403 RCV001222269 rs184146463 RCV002562551 |
345 | A>S | Joubert syndrome 15 Inborn genetic diseases [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
CA4485402 RCV001207993 rs184146463 |
345 | A>T | Joubert syndrome 15 [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
rs782371437 RCV001051405 RCV002553253 RCV001772257 CA4485401 |
346 | Q>R | Joubert syndrome 15 (jbts15) Joubert syndrome 15 Inborn genetic diseases [Ensembl, ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
CA4485400 rs782131552 RCV002561202 RCV001205893 |
347 | N>S | Joubert syndrome 15 Inborn genetic diseases [ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
RCV001230240 COSM3411587 CA4485396 rs782590600 |
352 | G>S | Variant assessed as Somatic; 0.0 impact. central_nervous_system Joubert syndrome 15 [NCI-TCGA, Cosmic, ClinVar] | Yes |
ClinGen cosmic curated ClinVar ExAC NCI-TCGA TOPMed dbSNP gnomAD |
|
CA4485393 rs201490201 RCV001316706 |
354 | A>T | Joubert syndrome 15 [ClinVar] | Yes |
ClinGen ClinVar ExAC dbSNP gnomAD |
|
RCV000536528 RCV001584325 rs116313397 CA4485389 |
355 | S>R | Joubert syndrome 15 [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
RCV000023828 VAR_067058 rs371812716 CA129496 RCV001295978 |
360 | R>C | Joubert syndrome 9/15, digenic Joubert syndrome 15 probable disease-associated variant found in a patient with Joubert syndrome; digenic inheritance; the patient also carries mutation A-1447 in CC2D2A [ClinVar, UniProt] | Yes |
ClinGen ClinVar UniProt ExAC TOPMed dbSNP gnomAD |
|
CA4485384 rs201504407 RCV001314529 |
363 | S>G | Joubert syndrome 15 [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
rs1796754986 RCV001229788 |
364 | S>missing | Joubert syndrome 15 [ClinVar] | Yes |
ClinVar dbSNP |
|
RCV001232057 rs139909606 CA4485377 |
372 | W>* | Joubert syndrome 15 [ClinVar] | Yes |
ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD |
| TCGA novel | 1 | M>? | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA369289591 rs782137799 |
2 | S>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1270454400 CA369289581 |
3 | L>P | No |
ClinGen TOPMed |
|
|
rs371561300 CA4485754 |
4 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA4485753 COSM1737741 rs782048004 |
5 | R>G | central_nervous_system [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
rs1240057172 CA369289564 |
5 | R>K | No |
ClinGen TOPMed |
|
|
CA4485752 rs147494464 |
7 | I>N | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA369289503 rs1554427535 |
9 | N>S | No |
ClinGen gnomAD |
|
|
CA369289491 rs1456565706 |
10 | P>R | No |
ClinGen TOPMed |
|
|
CA4485749 rs149373377 |
10 | P>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 11 | E>= | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA369287373 rs1348618417 |
18 | P>S | No |
ClinGen TOPMed |
|
|
rs782733242 CA4485714 |
21 | P>R | No |
ClinGen ExAC gnomAD |
|
|
CA4485713 rs782047730 |
23 | Y>D | No |
ClinGen ExAC |
|
|
rs577102638 CA4485712 |
24 | Q>E | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA369287243 rs1554424117 |
24 | Q>R | No |
ClinGen gnomAD |
|
|
CA369287211 rs1554424111 |
26 | I>V | No |
ClinGen gnomAD |
|
|
CA4485711 rs371724040 |
30 | L>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 31 | D>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs976909451 CA166871019 |
33 | G>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs782494512 CA4485685 |
33 | G>V | No |
ClinGen ExAC gnomAD |
|
|
rs1554421049 CA369284662 |
34 | N>D | No |
ClinGen gnomAD |
|
|
rs781793746 CA369284646 |
34 | N>K | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 35 | S>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 36 | M>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA4485683 rs782728353 |
36 | M>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA166864453 rs1037868181 |
37 | T>A | No |
ClinGen Ensembl |
|
|
rs1182566204 CA369284567 |
39 | Y>H | No |
ClinGen TOPMed |
|
|
CA4485681 rs782779830 |
41 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs781963259 CA4485679 |
43 | L>V | No |
ClinGen ExAC gnomAD |
|
|
rs1554421027 CA369284433 |
46 | I>T | No |
ClinGen gnomAD |
|
|
rs782061584 CA4485677 |
46 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs889368989 CA166864413 |
47 | K>E | No |
ClinGen Ensembl |
|
|
rs1161916455 CA369284377 |
49 | N>Y | No |
ClinGen TOPMed |
|
|
rs782788278 CA4485656 |
50 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA369290859 rs1562984818 RCV000723142 |
50 | Y>H | No |
ClinGen ClinVar Ensembl dbSNP |
|
|
CA369290821 rs1554419929 |
52 | Y>N | No |
ClinGen gnomAD |
|
|
CA369290803 rs1554419921 |
53 | K>E | No |
ClinGen gnomAD |
|
|
CA369290768 rs1164943584 |
54 | K>N | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 55 | D>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA4485654 rs781848679 |
55 | D>N | No |
ClinGen ExAC |
|
| rs781888984 | 55 | D>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs782776244 CA4485652 |
55 | D>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA369290758 rs781848679 |
55 | D>Y | No |
ClinGen ExAC |
|
|
rs964301542 CA166909243 |
57 | L>V | No |
ClinGen Ensembl |
|
|
CA369290653 rs1160416225 |
60 | R>G | No |
ClinGen TOPMed |
|
|
CA369290620 rs1554419898 |
62 | K>Q | No |
ClinGen gnomAD |
|
|
CA369290601 rs1554419897 |
63 | V>D | No |
ClinGen Ensembl |
|
|
CA4485648 rs782070060 |
65 | T>A | No |
ClinGen ExAC gnomAD |
|
|
rs782023923 CA4485647 |
66 | F>C | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 69 | L>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs781991354 CA4485628 |
73 | V>L | No |
ClinGen ExAC gnomAD |
|
|
CA369289967 rs1554419625 |
74 | A>V | No |
ClinGen gnomAD |
|
|
rs1554419617 CA369289946 |
76 | L>P | No |
ClinGen gnomAD |
|
|
CA4485627 rs782718109 |
79 | Q>L | No |
ClinGen ExAC gnomAD |
|
|
rs782093879 CA4485626 |
80 | T>K | No |
ClinGen ExAC gnomAD |
|
|
rs1554419609 CA369289862 |
83 | V>M | No |
ClinGen gnomAD |
|
|
CA369289833 rs1554419595 |
85 | A>G | No |
ClinGen gnomAD |
|
| VAR_067054 | 89 | Q>E | found in a patient with Meckel syndrome; unknown pathological significance [UniProt] | No | UniProt |
|
rs781918475 CA4485623 |
91 | L>V | No |
ClinGen ExAC gnomAD |
|
|
rs150251054 CA4485609 |
100 | D>H | No |
ClinGen ESP ExAC |
|
|
CA369289410 rs1554417856 |
101 | P>S | No |
ClinGen gnomAD |
|
|
CA4485607 rs781835148 |
102 | D>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1554417847 CA369289399 |
103 | A>T | No |
ClinGen gnomAD |
|
|
CA4485606 rs369687508 |
103 | A>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1237526302 CA369289394 |
104 | E>K | No |
ClinGen TOPMed |
|
|
rs782060662 CA4485605 |
105 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA4485604 rs141025803 |
107 | A>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs781994102 CA4485601 |
108 | R>K | No |
ClinGen ExAC gnomAD |
|
|
CA369289358 rs1554417824 |
110 | N>D | No |
ClinGen gnomAD |
|
|
CA369289355 rs1554417823 |
110 | N>S | No |
ClinGen gnomAD |
|
| TCGA novel | 111 | G>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs782349245 CA4485600 |
117 | E>G | No |
ClinGen ExAC gnomAD |
|
|
rs781927158 CA4485598 |
118 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
rs782235279 CA4485599 |
118 | Q>R | No |
ClinGen ExAC |
|
|
CA4485597 rs377707022 |
119 | S>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA369289294 rs377707022 |
119 | S>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA4485596 rs782275564 |
120 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782508627 CA4485594 |
121 | S>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA166905306 rs907155632 |
121 | S>R | No |
ClinGen TOPMed gnomAD |
|
|
rs782508627 CA369289285 |
121 | S>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782614895 CA369289274 |
123 | E>* | No |
ClinGen ExAC gnomAD |
|
|
rs782614895 CA4485592 |
123 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
rs1467651379 CA369289248 |
125 | F>L | No |
ClinGen TOPMed |
|
|
rs782784827 CA4485589 COSM1085547 |
129 | A>T | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs1554417797 CA369289187 |
129 | A>V | No |
ClinGen gnomAD |
|
|
rs1554417794 CA369289171 |
131 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA369289142 rs1554417790 |
133 | D>A | No |
ClinGen TOPMed gnomAD |
|
|
rs1554417790 CA369289145 |
133 | D>V | No |
ClinGen TOPMed gnomAD |
|
|
rs781846728 CA4485588 |
134 | S>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs781846728 CA4485587 |
134 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1445024969 CA369289134 |
134 | S>P | No |
ClinGen TOPMed gnomAD |
|
|
CA166905273 rs782212510 |
135 | S>G | No |
ClinGen Ensembl |
|
|
CA166905268 rs200669032 |
136 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
CA4485586 rs546106020 |
136 | R>H | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1554417775 CA369289093 |
137 | S>L | No |
ClinGen gnomAD |
|
|
CA4485585 rs782079407 |
137 | S>P | No |
ClinGen ExAC gnomAD |
|
|
rs1319297274 CA369289088 |
138 | T>A | No |
ClinGen TOPMed gnomAD |
|
|
rs1219186829 CA369289081 |
138 | T>I | No |
ClinGen TOPMed |
|
|
rs1562978882 CA369288995 |
142 | V>A | No |
ClinGen Ensembl |
|
|
CA4485568 rs782614635 |
143 | I>T | No |
ClinGen ExAC gnomAD |
|
|
CA4485566 rs781814259 |
145 | G>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs369257635 CA4485565 |
150 | D>N | No |
ClinGen ESP ExAC gnomAD |
|
|
CA166904319 rs547614936 |
152 | D>G | No |
ClinGen Ensembl |
|
|
rs1426742181 CA369288927 |
153 | K>R | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 154 | G>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1554417303 CA369288921 |
154 | G>W | No |
ClinGen gnomAD |
|
|
CA369288915 rs1303842941 |
155 | P>S | No |
ClinGen TOPMed |
|
|
CA369288901 COSM484828 rs1364977994 |
157 | K>R | kidney Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA TOPMed |
|
rs1554417299 CA369288892 |
158 | K>I | No |
ClinGen gnomAD |
|
|
CA369288884 rs1554417296 |
159 | A>V | No |
ClinGen gnomAD |
|
|
rs1554417292 CA369288873 |
161 | P>L | No |
ClinGen gnomAD |
|
|
rs933949303 CA166904316 |
161 | P>S | No |
ClinGen Ensembl |
|
|
CA369288868 rs1554417291 |
162 | H>Y | No |
ClinGen gnomAD |
|
|
rs782167856 CA4485563 |
165 | D>G | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 167 | P>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA369288823 rs1554417288 |
168 | Y>C | No |
ClinGen gnomAD |
|
|
CA4485561 rs782795776 |
169 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA369288731 rs782036013 |
179 | R>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs782036013 CA4485556 |
179 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA369288716 rs1246167043 |
180 | D>G | No |
ClinGen TOPMed |
|
|
CA369288683 rs1554417268 |
182 | D>E | No |
ClinGen gnomAD |
|
|
CA4485555 rs782252494 |
182 | D>N | No |
ClinGen ExAC |
|
|
rs1554417263 CA369288674 |
183 | S>C | No |
ClinGen gnomAD |
|
|
CA4485553 rs782352855 |
186 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
CA4485551 rs782591147 |
189 | I>L | No |
ClinGen ExAC gnomAD |
|
|
rs782591147 CA369288592 |
189 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA369288578 rs1554417253 |
190 | V>F | No |
ClinGen gnomAD |
|
|
CA369288582 rs1554417253 |
190 | V>I | No |
ClinGen gnomAD |
|
|
rs868975261 CA369288565 |
191 | G>* | No |
ClinGen Ensembl |
|
|
rs782542855 CA4485550 |
191 | G>E | No |
ClinGen ExAC gnomAD |
|
|
CA369288461 rs201818904 |
193 | Y>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4485530 rs201818904 |
193 | Y>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1554417028 CA369288429 COSM203809 |
195 | Y>C | large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
rs782044490 CA4485529 |
196 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs782265732 CA4485527 |
197 | I>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782265732 CA4485528 |
197 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782605784 CA4485526 |
198 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA369288346 rs1554417018 |
203 | T>A | No |
ClinGen gnomAD |
|
|
rs782188831 CA4485525 |
204 | M>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA369288331 rs1230657361 |
204 | M>T | No |
ClinGen TOPMed |
|
|
CA369288306 rs1554417012 |
205 | N>K | No |
ClinGen gnomAD |
|
|
rs143303575 CA369288303 |
206 | P>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA4485522 rs782541988 |
207 | Y>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA369288228 rs1584869641 |
211 | I>T | No |
ClinGen Ensembl |
|
| TCGA novel | 212 | L>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1490823242 CA369288220 |
212 | L>I | No |
ClinGen TOPMed |
|
|
rs782466306 CA4485519 |
213 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4485502 rs782434620 |
215 | K>E | No |
ClinGen ExAC |
|
|
CA4485500 rs781813813 |
216 | N>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs368968232 CA4485499 |
217 | A>T | No |
ClinGen ESP ExAC gnomAD |
|
|
CA4485497 rs527896814 |
218 | H>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA4485498 rs782550186 |
218 | H>Y | No |
ClinGen ExAC gnomAD |
|
|
CA369288040 rs1554416718 |
220 | K>N | No |
ClinGen gnomAD |
|
|
rs1472855500 CA369288044 |
220 | K>R | No |
ClinGen TOPMed |
|
|
CA4485495 rs560824415 |
222 | I>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA369287992 rs1409468056 |
224 | L>P | No |
ClinGen TOPMed |
|
|
rs1554416694 CA369287942 |
228 | D>N | No |
ClinGen gnomAD |
|
|
CA369287933 rs1554416692 |
228 | D>V | No |
ClinGen gnomAD |
|
|
CA369287919 rs1554416688 |
229 | E>A | No |
ClinGen gnomAD |
|
|
CA166903290 rs1057178000 |
230 | R>S | No |
ClinGen TOPMed |
|
|
CA4485491 rs373669246 |
232 | A>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA4485490 rs370522984 |
235 | A>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs781947734 CA4485488 |
239 | M>V | No |
ClinGen ExAC gnomAD |
|
|
rs782411902 CA4485485 |
241 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 246 | N>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1251966803 CA369287728 |
247 | L>V | No |
ClinGen TOPMed |
|
|
rs1562977278 CA369287695 |
249 | M>R | No |
ClinGen Ensembl |
|
|
CA4485480 rs782627258 |
250 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs1554416656 CA369287657 |
252 | G>E | No |
ClinGen gnomAD |
|
|
CA4485462 rs782548890 |
256 | V>I | No |
ClinGen ExAC gnomAD |
|
|
CA4485461 rs782548890 |
256 | V>L | No |
ClinGen ExAC gnomAD |
|
|
rs782241458 CA4485460 |
261 | F>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs781836610 CA4485457 |
268 | G>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA369287363 rs781836610 |
268 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA166902949 rs545675609 |
269 | S>F | No |
ClinGen 1000Genomes |
|
|
rs1584867599 CA369287354 |
269 | S>P | No |
ClinGen Ensembl |
|
|
rs782704918 CA4485456 |
271 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4485455 COSM1195170 rs782444437 |
272 | A>T | lung [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
CA4485454 rs781883377 |
275 | Q>E | No |
ClinGen ExAC gnomAD |
|
|
rs782815662 CA4485453 |
276 | Q>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1210916591 CA369287257 |
280 | P>S | No |
ClinGen TOPMed |
|
|
rs1554416501 CA369287250 |
281 | G>R | No |
ClinGen gnomAD |
|
|
rs782005408 CA4485451 |
283 | A>S | No |
ClinGen ExAC gnomAD |
|
|
CA369287229 rs1236914615 |
283 | A>V | No |
ClinGen TOPMed |
|
|
rs782729874 CA4485450 |
284 | R>W | No |
ClinGen ExAC gnomAD |
|
|
rs139123547 CA4485448 |
286 | R>* | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs11769911 CA4485447 |
286 | R>P | No |
ClinGen ExAC gnomAD |
|
|
rs11769911 CA166902866 |
286 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
CA4485446 rs782277834 |
288 | S>G | No |
ClinGen ExAC gnomAD |
|
|
CA369287178 rs1554416491 |
289 | P>S | No |
ClinGen gnomAD |
|
|
rs1180413412 CA369287137 |
293 | P>R | No |
ClinGen TOPMed gnomAD |
|
|
rs782208031 CA4485442 |
293 | P>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA369287128 rs1414616861 |
294 | L>P | No |
ClinGen TOPMed |
|
|
rs1554416471 CA369287058 |
301 | R>G | No |
ClinGen gnomAD |
|
|
CA369287031 rs1431624175 |
305 | E>* | No |
ClinGen TOPMed |
|
| TCGA novel | 309 | K>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs782435349 CA4485439 |
310 | I>K | No |
ClinGen ExAC gnomAD |
|
|
rs1308536722 CA369286992 |
310 | I>L | No |
ClinGen TOPMed |
|
|
CA369286988 rs1554416457 |
311 | E>* | No |
ClinGen gnomAD |
|
|
rs782192154 CA4485438 |
311 | E>G | No |
ClinGen ExAC gnomAD |
|
|
CA369286980 rs1349743180 |
312 | Y>H | No |
ClinGen TOPMed |
|
| TCGA novel | 315 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs782654308 CA4485436 |
317 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 317 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs781856872 CA4485434 |
322 | D>Y | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA4485433 rs782780788 |
323 | H>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA4485432 rs782474335 |
324 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4485412 rs782447449 |
330 | A>G | No |
ClinGen ExAC gnomAD |
|
|
rs368525533 CA4485414 |
330 | A>T | Joubert syndrome 15 (jbts15) [Ensembl] | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
CA369286833 rs1554416172 |
332 | S>C | No |
ClinGen gnomAD |
|
|
CA369286822 rs868934842 |
334 | G>A | No |
ClinGen Ensembl |
|
|
rs781865266 CA4485408 |
340 | P>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs781865266 CA369286786 |
340 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA369286777 rs1554416156 |
341 | G>V | No |
ClinGen gnomAD |
|
|
CA4485407 rs782738694 |
343 | R>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
COSM3765315 rs782089459 CA4485406 |
343 | R>Q | Variant assessed as Somatic; 0.0 impact. central_nervous_system breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs1584865994 CA369286764 |
344 | S>N | No |
ClinGen Ensembl |
|
|
CA369286749 rs1175088517 |
346 | Q>H | No |
ClinGen TOPMed |
|
|
rs781952691 CA4485399 |
349 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1393202405 CA369286730 |
350 | G>S | No |
ClinGen TOPMed gnomAD |
|
|
rs782359743 CA4485398 |
350 | G>V | No |
ClinGen ExAC |
|
|
CA166902122 rs894814775 |
351 | G>S | No |
ClinGen TOPMed gnomAD |
|
|
CA4485395 rs193073161 |
352 | G>A | No |
ClinGen ExAC gnomAD |
|
|
rs193073161 CA166900277 |
352 | G>D | No |
ClinGen ExAC gnomAD |
|
|
rs782590600 CA369286519 |
352 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1296687719 CA369286506 |
353 | P>H | No |
ClinGen TOPMed |
|
|
CA369286502 rs1296687719 |
353 | P>L | No |
ClinGen TOPMed |
|
|
rs1554416123 CA369286507 |
353 | P>S | No |
ClinGen gnomAD |
|
|
CA4485392 rs201490201 |
354 | A>P | No |
ClinGen ExAC gnomAD |
|
|
CA4485391 rs781832103 |
354 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM1187435 rs782809600 CA4485388 |
359 | P>A | lung [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
RCV000722982 rs1554416099 |
359 | P>LQVPHQANFFVF* | No |
ClinVar dbSNP |
|
|
rs1036892115 CA166900233 |
359 | P>R | No |
ClinGen Ensembl |
|
|
rs782809600 CA4485387 |
359 | P>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA4485386 rs781878740 |
360 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs781878740 CA369286420 |
360 | R>P | No |
ClinGen ExAC gnomAD |
|
|
CA231012 RCV000116676 rs587780311 |
361 | S>P | No |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
|
rs1437589015 CA369286370 |
365 | G>S | No |
ClinGen TOPMed |
|
|
rs782713689 CA4485383 |
366 | H>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782042321 CA4485381 |
367 | L>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1248130871 CA369286340 |
367 | L>V | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 368 | Q>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA4485379 rs782211413 |
371 | P>T | No |
ClinGen ExAC |
|
|
rs1451295403 CA369286273 |
372 | W>* | No |
ClinGen TOPMed |
No associated diseases with Q9BYV8
1 regional properties for Q9BYV8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cytochrome b5-like heme/steroid binding domain | 64 - 162 | IPR001199 |
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| centriole | A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle. |
| centrosome | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. |
| ciliary basal body | A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport. |
| cilium | A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cilium assembly | The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. |
| protein polyglutamylation | The addition of one or more alpha-linked glutamyl units to the gamma carboxyl group of peptidyl-glutamic acid. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| F1MUG2 | CEP41 | Centrosomal protein of 41 kDa | Bos taurus (Bovine) | PR |
| Q99NF3 | Cep41 | Centrosomal protein of 41 kDa | Mus musculus (Mouse) | PR |
| Q4KM37 | Cep41 | Centrosomal protein of 41 kDa | Rattus norvegicus (Rat) | PR |
| Q6GQN0 | cep41 | Centrosomal protein of 41 kDa | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSLRRHIGNP | EYLMKRIPQN | PRYQHIKSRL | DTGNSMTKYT | EKLEEIKKNY | RYKKDELFKR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LKVTTFAQLI | IQVASLSDQT | LEVTAEEIQR | LEDNDSAASD | PDAETTARTN | GKGNPGEQSP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SPEQFINNAG | AGDSSRSTLQ | SVISGVGELD | LDKGPVKKAE | PHTKDKPYPD | CPFLLLDVRD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RDSYQQCHIV | GAYSYPIATL | SRTMNPYSND | ILEYKNAHGK | IIILYDDDER | LASQAATTMC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ERGFENLFML | SGGLKVLAQK | FPEGLITGSL | PASCQQALPP | GSARKRSSPK | GPPLPAENKW |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RFTPEDLKKI | EYYLEEEQGP | ADHPSRLNQA | NSSGRESKVP | GARSAQNLPG | GGPASHSNPR |
| 370 | |||||
| SLSSGHLQGK | PWK |