Q4KM37
Gene name |
Cep41 (Tsga14) |
Protein name |
Centrosomal protein of 41 kDa |
Names |
Cep41, Testis-specific gene A14 protein |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:500069 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q4KM37
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q4KM37-F1 | Predicted | AlphaFoldDB |
2 variants for Q4KM37
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs197320296 | 299 | A>P | No | EVA | |
| rs3320194703 | 317 | G>S | No | EVA |
No associated diseases with Q4KM37
1 regional properties for Q4KM37
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Rhodanese-like domain | 117 - 232 | IPR001763 |
Functions
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| centriole | A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle. |
| centrosome | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. |
| ciliary basal body | A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport. |
| cilium | A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cilium assembly | The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. |
| protein polyglutamylation | The addition of one or more alpha-linked glutamyl units to the gamma carboxyl group of peptidyl-glutamic acid. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| F1MUG2 | CEP41 | Centrosomal protein of 41 kDa | Bos taurus (Bovine) | PR |
| Q9BYV8 | CEP41 | Centrosomal protein of 41 kDa | Homo sapiens (Human) | PR |
| Q99NF3 | Cep41 | Centrosomal protein of 41 kDa | Mus musculus (Mouse) | PR |
| Q6GQN0 | cep41 | Centrosomal protein of 41 kDa | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSDSPIDGSP | QPEPDYRYKK | DELFKRIKVT | TFAQLVIQVA | SLSDQTLEVT | AEEIQRLEDS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DSATSEADTD | IAAKTNGKGS | PEEQSPSPVQ | FINSTGAGDA | SRSTLQSVIS | GVGELDVDKG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LVKKEEPSGK | DKPYPDCPFL | LLDVRDRDSY | QQCHIVGAYS | YPIATLSRTM | NPYSNDILEY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KNAHGKIIIL | YDDDERLASQ | AATTMCERGF | ENLFMLSGGL | KVLAQKFPEG | LVTGSLPASC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QQALPFGSVR | KRPGPKMPAL | PAENKWRFTP | EDLKKIECYL | EADQGPANNP | SRLNQNNSAG |
| 310 | 320 | 330 | |||
| RDLKVPAGRG | GQNLPTGCPT | SHSNSRTLNS | GHLQGKPWK |