AiPD: Autoinhibited Protein Database

Q9BYC9

Gene name	MRPL20
Protein name	39S ribosomal protein L20, mitochondrial
Names	L20mt, MRP-L20, Mitochondrial large ribosomal subunit protein bL20m
Species	Homo sapiens (Human)
KEGG Pathway	hsa:55052
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

89-149 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

89-149 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

61 structures for Q9BYC9

Entry ID	Method	Resolution	Chain	Position	Source
3J7Y	EM	340 A	R	1-149	PDB
3J9M	EM	350 A	R	1-149	PDB
5OOL	EM	306 A	R	1-149	PDB
5OOM	EM	303 A	R	1-149	PDB
6I9R	EM	390 A	R	1-149	PDB
6NU2	EM	390 A	R	10-149	PDB
6NU3	EM	440 A	R	1-149	PDB
6VLZ	EM	297 A	R	1-149	PDB
6VMI	EM	296 A	R	1-149	PDB
6ZM5	EM	289 A	R	1-149	PDB
6ZM6	EM	259 A	R	1-149	PDB
6ZS9	EM	400 A	XR	1-149	PDB
6ZSA	EM	400 A	XR	1-149	PDB
6ZSB	EM	450 A	XR	1-149	PDB
6ZSC	EM	350 A	XR	1-149	PDB
6ZSD	EM	370 A	XR	1-149	PDB
6ZSE	EM	500 A	XR	1-149	PDB
6ZSG	EM	400 A	XR	1-149	PDB
7A5F	EM	440 A	R3	1-149	PDB
7A5G	EM	433 A	R3	1-149	PDB
7A5H	EM	330 A	R	1-149	PDB
7A5I	EM	370 A	R3	1-149	PDB
7A5J	EM	310 A	R	1-149	PDB
7A5K	EM	370 A	R3	1-149	PDB
7L08	EM	349 A	R	1-149	PDB
7L20	EM	315 A	R	1-149	PDB
7O9K	EM	310 A	R	1-149	PDB
7O9M	EM	250 A	R	1-149	PDB
7ODR	EM	290 A	R	1-149	PDB
7ODS	EM	310 A	R	1-149	PDB
7ODT	EM	310 A	R	1-149	PDB
7OF0	EM	220 A	R	1-149	PDB
7OF2	EM	270 A	R	1-149	PDB
7OF3	EM	270 A	R	1-149	PDB
7OF4	EM	270 A	R	1-149	PDB
7OF5	EM	290 A	R	1-149	PDB
7OF6	EM	260 A	R	1-149	PDB
7OF7	EM	250 A	R	1-149	PDB
7OG4	EM	380 A	XR	1-149	PDB
7OI6	EM	570 A	R	1-149	PDB
7OI7	EM	350 A	R	1-149	PDB
7OI8	EM	350 A	R	1-149	PDB
7OI9	EM	330 A	R	1-149	PDB
7OIA	EM	320 A	R	1-149	PDB
7OIB	EM	330 A	R	1-149	PDB
7OIC	EM	310 A	R	1-149	PDB
7OID	EM	370 A	R	1-149	PDB
7OIE	EM	350 A	R	1-149	PDB
7PD3	EM	340 A	R	1-149	PDB
7PO4	EM	256 A	R	1-149	PDB
7QH6	EM	308 A	R	1-149	PDB
7QH7	EM	289 A	R	10-148	PDB
7QI4	EM	221 A	R	1-149	PDB
7QI5	EM	263 A	R	1-149	PDB
7QI6	EM	298 A	R	1-149	PDB
8ANY	EM	285 A	R	1-149	PDB
8OIR	EM	310 A	BY	1-149	PDB
8OIT	EM	290 A	BY	1-149	PDB
8PK0	EM	303 A	R	1-149	PDB
8QSJ	EM	300 A	R	1-149	PDB
AF-Q9BYC9-F1	Predicted				AlphaFoldDB

165 variants for Q9BYC9

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1416500198 CA337850063	2	V>F		No	ClinGen gnomAD
CA522774 rs773607247	3	F>Y		No	ClinGen ExAC gnomAD
CA522773 rs771566478	5	T>A		No	ClinGen ExAC TOPMed gnomAD
rs980432781 CA16787847	5	T>S		No	ClinGen Ensembl
rs969117726 CA16787837	6	A>P		No	ClinGen Ensembl
CA522771 rs778682635	6	A>V		No	ClinGen ExAC gnomAD
CA337849973 rs1238236087	7	Q>*		No	ClinGen gnomAD
CA522770 rs768478633	7	Q>H		No	ClinGen ExAC gnomAD
rs1570072980 CA337849970	7	Q>P		No	ClinGen Ensembl
CA337849956 rs1484580344	8	L>F		No	ClinGen TOPMed gnomAD
rs749088096 CA337849952	8	L>H		No	ClinGen ExAC TOPMed gnomAD
rs749088096 CA337849953	8	L>P		No	ClinGen ExAC TOPMed gnomAD
rs749088096 CA522769	8	L>R		No	ClinGen ExAC TOPMed gnomAD
CA522768 rs140228855	9	W>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs990729481 CA16787823	10	L>V		No	ClinGen TOPMed
CA337849898 rs1460325469	11	R>W		No	ClinGen TOPMed
CA16787822 rs958704334	12	N>K		No	ClinGen TOPMed
CA522766 rs750326271	13	R>H		No	ClinGen ExAC gnomAD
CA522765 rs781021756	14	V>I		No	ClinGen ExAC TOPMed gnomAD
CA522764 rs758442949	16	D>V		No	ClinGen ExAC gnomAD
rs752823750 CA337849719	17	R>H		No	ClinGen ExAC gnomAD
CA522763 rs752823750	17	R>L		No	ClinGen ExAC gnomAD
CA522762 rs765434184	19	F>L		No	ClinGen ExAC gnomAD
CA16787807 rs957744847	21	I>F		No	ClinGen Ensembl
CA522758 rs556155223	22	Q>L		No	ClinGen 1000Genomes ExAC gnomAD
rs556155223 CA522759	22	Q>P		No	ClinGen 1000Genomes ExAC gnomAD
CA522757 rs773732409	24	V>M		No	ClinGen ExAC gnomAD
rs1474310316 CA337849408	26	K>N		No	ClinGen gnomAD
rs761389193 CA522756	27	H>D		No	ClinGen ExAC TOPMed gnomAD
CA522755 rs761389193	27	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA522753 rs768282505	28	A>S		No	ClinGen ExAC gnomAD
CA522754 rs768282505	28	A>T		No	ClinGen ExAC gnomAD
rs1484019287 CA337849299	28	A>V		No	ClinGen gnomAD
rs545459704 CA522752	29	R>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs534896516 CA522718	30	H>D		No	ClinGen 1000Genomes gnomAD
CA522717 rs755015191	30	H>R		No	ClinGen ExAC gnomAD
rs534896516 CA522720	30	H>Y		No	ClinGen 1000Genomes gnomAD
rs780306569 CA522715	31	F>I		No	ClinGen ExAC gnomAD
CA337849099 rs11548045	31	F>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA522713 rs146625728	32	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	34	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757717526 CA522710	36	N>S		No	ClinGen ExAC gnomAD
CA337848963 rs1204511542	37	R>G		No	ClinGen gnomAD
CA337848870 rs1306301567	39	Y>C		No	ClinGen gnomAD
CA522708 rs752071730	40	R>T		No	ClinGen ExAC gnomAD
CA16787644 rs866223979	42	A>V		No	ClinGen gnomAD
rs1557751883 CA337847511	45	T>I		No	ClinGen Ensembl
CA337847489 rs1387300889	46	V>M		No	ClinGen TOPMed
CA337847413 rs764939710	48	R>L		No	ClinGen ExAC gnomAD
CA522704 rs764939710	48	R>P		No	ClinGen ExAC gnomAD
rs759046129 CA522703	49	A>T		No	ClinGen ExAC TOPMed gnomAD
CA337847345 rs1453655061	50	F>V		No	ClinGen TOPMed gnomAD
CA337847326 rs1557751858	51	V>M		No	ClinGen Ensembl
rs776280232 CA522702	53	C>G		No	ClinGen ExAC TOPMed gnomAD
rs776280232 CA337847269	53	C>R		No	ClinGen ExAC TOPMed gnomAD
CA16787614 rs949278866	54	T>A		No	ClinGen TOPMed
rs1426409912 CA337847186	54	T>I		No	ClinGen gnomAD
rs941300917 CA16787605	56	A>T		No	ClinGen Ensembl
CA337847110 rs1237230428	57	R>*		No	ClinGen TOPMed
CA522700 rs746840008	57	R>P		No	ClinGen ExAC TOPMed gnomAD
CA16787589 rs746840008	57	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs771956440 CA522698	58	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs773106869 CA522699	58	Y>H		No	ClinGen ExAC gnomAD
rs756228420 CA522695	61	K>*		No	ClinGen ExAC gnomAD
CA337846955 rs1352262771	61	K>N		No	ClinGen TOPMed
TCGA novel	61	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA16787534 rs939207365	63	N>D		No	ClinGen TOPMed gnomAD
rs1434091444 CA337846790	64	M>I		No	ClinGen gnomAD
CA522693 rs767711323	64	M>L		No	ClinGen ExAC TOPMed gnomAD
rs767711323 CA16787530	64	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1378923409 CA337846724	66	T>I		No	ClinGen TOPMed gnomAD
rs778081207 CA522652	68	W>*		No	ClinGen ExAC TOPMed gnomAD
rs772287553 CA522651	68	W>C		No	ClinGen ExAC TOPMed gnomAD
CA16786543 rs1029996589	70	N>K		No	ClinGen Ensembl
rs1363697717 CA337845984	70	N>S		No	ClinGen gnomAD
rs554233934 CA522649	71	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs145728085 CA522647	71	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA522648 rs145728085	71	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs779478327 CA522646	73	T>I		No	ClinGen ExAC gnomAD
CA337845827 rs779478327	73	T>R		No	ClinGen ExAC gnomAD
TCGA novel	74	A>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA16786508 rs1018637388	74	A>T		No	ClinGen TOPMed
CA337845738 rs1333691467	75	A>V		No	ClinGen TOPMed
rs201503869 CA522645	76	S>N		No	ClinGen 1000Genomes ExAC gnomAD
CA522643 COSM1257939 rs767237767	78	E>K	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1355502555 CA337845484	79	H>Q		No	ClinGen TOPMed gnomAD
CA16786501 rs1005910713	80	G>A		No	ClinGen Ensembl
CA337845458 rs1281922433	81	L>V		No	ClinGen gnomAD
CA522642 rs756978576	82	K>Q		No	ClinGen ExAC gnomAD
CA522641 rs200133158	84	P>S		No	ClinGen 1000Genomes ExAC gnomAD
CA16786490 rs985950676	85	A>P		No	ClinGen TOPMed
rs762917870 CA522639	85	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1320737828 CA337845224	86	L>I		No	ClinGen gnomAD
CA522636 rs200566000	87	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs140521637 CA522637	87	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs772390285 CA522634	89	N>S		No	ClinGen ExAC gnomAD
rs773277952 CA522635	89	N>Y		No	ClinGen ExAC gnomAD
CA337845058 rs1193077495	90	L>S		No	ClinGen gnomAD
rs748451206 CA522633	90	L>V		No	ClinGen ExAC gnomAD
CA16786483 rs1048712043	91	V>I		No	ClinGen Ensembl
CA337844943 rs1435717906	92	K>Q		No	ClinGen TOPMed
rs1570062427 CA337839041	93	C>F		No	ClinGen Ensembl
rs1406525788 CA337839029	94	Q>*		No	ClinGen TOPMed
CA337838970 rs1209300581	95	V>E		No	ClinGen gnomAD
rs1344403131 CA337838964	96	E>K		No	ClinGen gnomAD
CA337838958 rs1344403131	96	E>Q		No	ClinGen gnomAD
rs745802124 CA522558	98	N>H		No	ClinGen ExAC TOPMed gnomAD
CA337838898 rs1229969433	98	N>S		No	ClinGen gnomAD
rs1305982932 CA337838885	99	R>G		No	ClinGen TOPMed gnomAD
rs147211401 CA337838876	99	R>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA522557 rs147211401	99	R>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs758451041 CA522556	99	R>S		No	ClinGen ExAC gnomAD
rs1357077434 CA337838855	100	K>*		No	ClinGen gnomAD
rs752956375 CA522555	100	K>R		No	ClinGen ExAC TOPMed gnomAD
CA337838796 rs1396611949	103	A>E		No	ClinGen TOPMed gnomAD
CA337838793 rs1396611949	103	A>G		No	ClinGen TOPMed gnomAD
CA337838795 rs1396611949	103	A>V		No	ClinGen TOPMed gnomAD
CA337838782 rs1268547521	104	D>N		No	ClinGen TOPMed
CA522551 rs201348345 COSM1667068	107	I>M	Variant assessed as Somatic; impact. haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD
rs754090967 CA522552	107	I>V		No	ClinGen ExAC gnomAD
CA16783234 rs147976981	108	Y>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs767180281 CA522549	109	E>K		No	ClinGen ExAC TOPMed gnomAD
rs767180281 CA522548	109	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA522547 rs761370739	110	P>L		No	ClinGen ExAC TOPMed gnomAD
CA16783191 rs997180626	111	K>N		No	ClinGen Ensembl
rs768138326 CA522544	112	T>I		No	ClinGen ExAC gnomAD
rs1479810940 CA337838505	113	F>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs749115369 CA522543	114	K>E		No	ClinGen ExAC gnomAD
COSM1667067 rs899780142 CA16783158	115	S>F	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated Ensembl
CA522541 rs769564895	115	S>P		No	ClinGen ExAC gnomAD
rs1557749212 CA337838412	117	A>T		No	ClinGen Ensembl
CA337838313 rs1336246468	120	A>T		No	ClinGen gnomAD
CA337838278 rs1330364536	120	A>V		No	ClinGen gnomAD
rs748339623 CA16783141	121	S>N		No	ClinGen gnomAD
CA337838257 rs1296347394	121	S>R		No	ClinGen Ensembl
CA522537 rs748176422	124	R>*		No	ClinGen ExAC TOPMed gnomAD
CA522536 rs779206797	124	R>Q		No	ClinGen ExAC gnomAD
CA522534 rs147491797	125	H>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA522532 rs756520442	125	H>Q		No	ClinGen ExAC gnomAD
rs147491797 CA337838194	125	H>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs755087224 CA522535	125	H>Y		No	ClinGen ExAC gnomAD
CA337838160 rs1184544105	126	E>D		No	ClinGen gnomAD
CA16783056 COSM178149 rs775815488	126	E>K	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA522531 rs751003271	127	G>A		No	ClinGen ExAC TOPMed gnomAD
rs768092342 CA522530	129	A>S		No	ClinGen ExAC gnomAD
rs202174742 CA522529	129	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs773670554 CA522528	130	A>T		No	ClinGen ExAC gnomAD
CA522527 rs763657881	130	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1281241337 CA337838069	131	A>D		No	ClinGen gnomAD
CA337838082 rs1390878835	131	A>T		No	ClinGen TOPMed
CA337838061 CA522525 rs564241399	132	L>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA522526 rs762571648	132	L>S		No	ClinGen ExAC gnomAD
rs1468665482 CA522523	133	G>V		No	ClinGen TOPMed
rs776570809 CA522520	135	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1322047159 CA337837910	140	G>D		No	ClinGen gnomAD
rs1424064814 CA337837914	140	G>S		No	ClinGen TOPMed gnomAD
CA522519 rs368168904	141	I>N		No	ClinGen ESP ExAC TOPMed
CA337837904 rs1456931149	141	I>V		No	ClinGen TOPMed
rs778923129 CA522517	144	R>G		No	ClinGen ExAC gnomAD
CA522515 rs547600708	144	R>K		No	ClinGen 1000Genomes
rs145885719 CA522514	144	R>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1418349141 CA337837797	145	V>A		No	ClinGen gnomAD
CA522513 rs749517060	146	V>G		No	ClinGen ExAC gnomAD
rs559305675 CA337837734	149	H>N		No	ClinGen gnomAD
rs559305675 CA16782976	149	H>Y		No	ClinGen gnomAD

No associated diseases with Q9BYC9

No regional properties for Q9BYC9

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9BYC9

Functions

		Description
EC Number
Subcellular Localization	Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
mitochondrial inner membrane	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial large ribosomal subunit	The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).
mitochondrial ribosome	A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

3 GO annotations of molecular function

Name	Definition
RNA binding	Binding to an RNA molecule or a portion thereof.
rRNA binding	Binding to a ribosomal RNA.
structural constituent of ribosome	The action of a molecule that contributes to the structural integrity of the ribosome.

2 GO annotations of biological process

Name	Definition
mitochondrial translation	The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.
ribosomal large subunit assembly	The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q2TBR2	MRPL20	39S ribosomal protein L20, mitochondrial	Bos taurus (Bovine)	PR

10	20	30	40	50	60
MVFLTAQLWL	RNRVTDRYFR	IQEVLKHARH	FRGRKNRCYR	LAVRTVIRAF	VKCTKARYLK
70	80	90	100	110	120
KKNMRTLWIN	RITAASQEHG	LKYPALIGNL	VKCQVELNRK	VLADLAIYEP	KTFKSLAALA
130	140
SRRRHEGFAA	ALGDGKEPEG	IFSRVVQYH