AiPD: Autoinhibited Protein Database

Q9BRV8

Gene name	SIKE1 (SIKE)
Protein name	Suppressor of IKBKE 1
Names	Suppressor of IKK-epsilon
Species	Homo sapiens (Human)
KEGG Pathway	hsa:80143
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

34-110 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

34-110 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for Q9BRV8

Entry ID	Method	Resolution	Chain	Position	Source
6AKK	X-ray	150 A	A/B	72-121	PDB
6AKL	X-ray	175 A	A/B	72-121	PDB
6AKM	X-ray	230 A	A	5-65	PDB
AF-Q9BRV8-F1	Predicted				AlphaFoldDB

162 variants for Q9BRV8

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1360137451 CA341744062	2	S>G		No	ClinGen gnomAD
CA1021632 rs150712455	4	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA341744017 rs1468475838	4	T>I		No	ClinGen gnomAD
rs1468475838 CA341744020	4	T>S		No	ClinGen gnomAD
CA341743987 rs768306724	5	I>M		No	ClinGen TOPMed
rs755191200 CA1021630	6	E>D		No	ClinGen ExAC TOPMed gnomAD
CA1021631 rs778933224	6	E>G		No	ClinGen ExAC TOPMed gnomAD
rs754261782 CA1021629	7	K>*		No	ClinGen ExAC gnomAD
rs1405806878 CA341743958	7	K>R		No	ClinGen gnomAD
rs563914204 CA341743946	8	I>F		No	ClinGen 1000Genomes ExAC gnomAD
CA341743927 rs1557724898	8	I>M		No	ClinGen Ensembl
rs563914204 CA1021628	8	I>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1397294893 CA341743923	9	L>V		No	ClinGen TOPMed
rs750856551 CA1021626	12	A>T		No	ClinGen ExAC gnomAD
rs763682584 CA1021625	12	A>V		No	ClinGen ExAC TOPMed gnomAD
rs200650263 CA1021624	13	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs775214261 CA1021623	14	T>M		No	ClinGen ExAC gnomAD
rs1570993594 CA341743815	16	L>R		No	ClinGen Ensembl
rs759239938 CA1021621	17	E>G		No	ClinGen ExAC gnomAD
CA341743808 rs1326479010	17	E>Q		No	ClinGen gnomAD
rs776607162 CA1021620	18	R>M		No	ClinGen ExAC gnomAD
rs746961345 CA1021618	20	R>P		No	ClinGen ExAC TOPMed gnomAD
CA1021619 rs374543119	20	R>W		No	ClinGen ESP ExAC gnomAD
rs772960809 CA1021617	21	E>V		No	ClinGen ExAC gnomAD
rs770290600 CA1021616	22	H>N		No	ClinGen ExAC gnomAD
CA29053932 rs868834171	22	H>P		No	ClinGen Ensembl
CA341743659 rs1570993488	23	D>E		No	ClinGen Ensembl
rs1458973002 CA341743683	23	D>N		No	ClinGen gnomAD
rs1570993496 CA341743664	23	D>V		No	ClinGen Ensembl
CA341743649 rs1441616404	24	A>G		No	ClinGen TOPMed
rs1570993469 CA341743644	25	A>P		No	ClinGen Ensembl
rs1158437477 CA341743620	26	A>G		No	ClinGen gnomAD
CA341743577 rs1405934600	28	S>L		No	ClinGen TOPMed gnomAD
rs1405934600 CA341743579	28	S>W		No	ClinGen TOPMed gnomAD
rs1181600311 CA341743545	30	V>A		No	ClinGen gnomAD
rs1570993419 CA341743475	33	S>L		No	ClinGen Ensembl
CA1021611 rs780432009	34	A>E		No	ClinGen ExAC gnomAD
CA1021612 rs755246162	34	A>T		No	ClinGen ExAC gnomAD
CA1021610 rs780432009	34	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA1021609 rs756421782	36	L>Q		No	ClinGen ExAC TOPMed gnomAD
rs767846232 CA1021607	38	R>G		No	ClinGen ExAC gnomAD
CA1021608 rs767846232	38	R>W		No	ClinGen ExAC gnomAD
CA341743404 rs1478444117	39	R>W		No	ClinGen TOPMed gnomAD
CA1021605 rs77284809	40	V>G		No	ClinGen ExAC gnomAD
rs1298742670 CA341743372	41	A>G		No	ClinGen gnomAD
rs764808045 CA1021604	42	A>D		No	ClinGen ExAC gnomAD
rs1557724760 CA341743355	43	M>L		No	ClinGen Ensembl
rs1288425622 CA341743330	45	E>K		No	ClinGen gnomAD
CA1021602 rs776374063	46	A>G		No	ClinGen ExAC gnomAD
TCGA novel	48	T>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773052993 CA1021599	49	A>G		No	ClinGen ExAC TOPMed gnomAD
CA1021600 rs760317746	49	A>T		No	ClinGen ExAC TOPMed gnomAD
rs773052993 CA341743271	49	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1570993256 CA341743266	50	L>P		No	ClinGen Ensembl
rs771964431 CA1021598	51	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1170220485 CA341743258	52	D>H		No	ClinGen gnomAD
rs1198007713 CA341743164	54	Y>C		No	ClinGen gnomAD
CA29053554 rs759010941	54	Y>N		No	ClinGen gnomAD
CA1021582 rs753541270	57	D>G		No	ClinGen ExAC gnomAD
CA29053529 rs762511760	59	S>T		No	ClinGen Ensembl
rs1251062157 CA341743082	60	D>A		No	ClinGen gnomAD
CA1021581 rs201419027	61	M>I		No	ClinGen ExAC TOPMed gnomAD
CA341743073 rs1190119230	61	M>V		No	ClinGen TOPMed
CA341743012 rs1472401922	64	M>I		No	ClinGen TOPMed
CA341743016 rs1281513534	64	M>T		No	ClinGen gnomAD
rs1325892527 CA341743022	64	M>V		No	ClinGen gnomAD
CA341742993 rs1351108067	66	K>E		No	ClinGen gnomAD
CA525631074 rs1332704354	67	Y>*		No	ClinGen TOPMed gnomAD
rs750236933 CA1021579	67	Y>F		No	ClinGen ExAC gnomAD
CA1021580 rs760359840	67	Y>H		No	ClinGen ExAC gnomAD
rs549596069 CA1021578	70	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA341742922 rs1303180301	72	L>M		No	ClinGen gnomAD
CA29053517 rs148582859	73	L>P		No	ClinGen ESP
rs1357510766 CA341742510	75	Q>R		No	ClinGen gnomAD
CA341742468 rs1175385081	77	N>S		No	ClinGen gnomAD
CA1021574 rs762957321	81	R>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1416293254 CA341742399	82	D>N		No	ClinGen TOPMed
rs1331571917 CA341742300	86	E>A		No	ClinGen TOPMed
rs769971074 CA1021572	87	N>D		No	ClinGen ExAC gnomAD
rs1557724251 CA341742133	90	L>I		No	ClinGen Ensembl
rs759696492 CA1021542	94	L>S		No	ClinGen ExAC gnomAD
rs1183942233 CA341742080	95	E>K		No	ClinGen gnomAD
CA1021541 rs776850871	97	H>Q		No	ClinGen ExAC gnomAD
CA341742062 rs1557724238	97	H>R		No	ClinGen Ensembl
CA341742054 rs1295073122	98	Q>R		No	ClinGen TOPMed
CA29053028 rs943251520	99	D>N		No	ClinGen Ensembl
rs910397184 CA29053020	102	E>G		No	ClinGen gnomAD
CA1021540 rs369946484	103	L>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA1021539 rs201941400	104	I>T		No	ClinGen ExAC TOPMed gnomAD
CA341742010 rs1210256853	105	M>K		No	ClinGen gnomAD
rs1280283925 CA341741992	107	K>R		No	ClinGen TOPMed
CA341741978 rs1434769856	109	R>Q		No	ClinGen TOPMed gnomAD
rs1021020518 CA29052941	112	M>I		No	ClinGen TOPMed
rs780834239 CA1021532	114	Q>E		No	ClinGen ExAC TOPMed
rs535564914 CA1021531	115	L>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1390723672 CA341741921	117	V>I		No	ClinGen gnomAD
rs138166048 CA1021530	118	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA341741897 rs1386667483	120	K>N		No	ClinGen gnomAD
rs958018166 CA29052907	120	K>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1163855157	121	A>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1192203713 CA341741889	121	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1240146949 CA341741883	122	V>L		No	ClinGen gnomAD
CA29052902 rs1032841342	124	A>T		No	ClinGen TOPMed
TCGA novel	124	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA29052901 rs375443289	126	P>S		No	ClinGen ESP gnomAD
CA1021528 rs758360808	127	V>I		No	ClinGen ExAC gnomAD
rs752578500 CA1021527	128	L>P		No	ClinGen ExAC gnomAD
rs144841007 CA29052887	130	A>T		No	ClinGen ESP
TCGA novel	132	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1337776475 CA341741756	134	H>L		No	ClinGen gnomAD
rs766680135 CA1021523	134	H>Y		No	ClinGen ExAC gnomAD
rs773749735 CA1021521	135	S>C		No	ClinGen ExAC TOPMed gnomAD
rs754857340 CA1021499	137	E>A		No	ClinGen ExAC gnomAD
rs1160970789 CA341741234	138	I>T		No	ClinGen gnomAD
CA29050964 rs977192715	140	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA1021495 rs141025380	143	D>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA1021496 rs141025380	143	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1481372669 CA341741192	144	R>K		No	ClinGen gnomAD
CA341741186 rs1445755975	145	I>V		No	ClinGen TOPMed
CA341741168 rs1176664567	147	E>G		No	ClinGen gnomAD
rs1412657625 CA341741172	147	E>K		No	ClinGen Ensembl
CA1021492 rs768008500	148	M>I		No	ClinGen ExAC gnomAD
rs144057351 CA1021493	148	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1311321192 CA341741126	153	R>W		No	ClinGen TOPMed
CA29050933 rs968931829	157	Q>K		No	ClinGen TOPMed gnomAD
rs1461098986 CA341741093	158	V>M		No	ClinGen gnomAD
CA341741076 rs1261655339	160	D>G		No	ClinGen gnomAD
rs774578994 CA1021489	162	Q>*		No	ClinGen ExAC gnomAD
CA29050888 rs879082329	168	E>K		No	ClinGen Ensembl
CA1021488 rs769268008	170	L>V		No	ClinGen ExAC gnomAD
TCGA novel	174	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs776248673 CA1021486	174	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs763535400 CA1021457	175	L>F		No	ClinGen ExAC TOPMed gnomAD
rs1346954162 CA341740770	176	E>*		No	ClinGen gnomAD
CA341740767 rs1159897528	176	E>A		No	ClinGen gnomAD
CA341740761 rs1383575695	177	N>I		No	ClinGen gnomAD
rs747099277 CA29049255	178	K>Q		No	ClinGen Ensembl
CA1021454 rs775799766	181	R>G		No	ClinGen ExAC gnomAD
CA1021453 rs149666360	181	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs760240834 CA1021452	182	E>G		No	ClinGen ExAC gnomAD
rs772695085 CA1021451	184	L>S		No	ClinGen ExAC TOPMed gnomAD
rs1201477439 CA341740707	185	S>F		No	ClinGen TOPMed
CA1021450 rs771759846	187	S>G		No	ClinGen ExAC gnomAD
CA29049163 rs747722904	188	S>G		No	ClinGen ExAC gnomAD
CA1021449 rs747722904	188	S>R		No	ClinGen ExAC gnomAD
rs986450374 CA29049160	189	E>G		No	ClinGen Ensembl
rs768289356 CA1021447	190	S>C		No	ClinGen ExAC gnomAD
rs778798621 CA1021448	190	S>P		No	ClinGen ExAC gnomAD
rs150908090 CA1021445	192	Q>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA341740661 rs1294568978	193	A>T		No	ClinGen gnomAD
CA29049117 rs967310677	195	K>E		No	ClinGen Ensembl
CA1021444 rs202098227	196	E>G		No	ClinGen ExAC TOPMed gnomAD
CA29049098 rs144894248	197	N>D		No	ClinGen ESP
CA1021443 rs118113115	199	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs781403382 CA1021442	200	D>G		No	ClinGen ExAC gnomAD
rs1321378621 CA341740596	202	A>V		No	ClinGen TOPMed
rs1305114258 CA341740591	203	S>C		No	ClinGen TOPMed gnomAD
CA341740590 rs1305114258	203	S>F		No	ClinGen TOPMed gnomAD
CA1021439 rs764530410	204	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1311056439 CA341740582	205	A>T		No	ClinGen TOPMed
CA1021437 rs753050772	206	I>V		No	ClinGen ExAC TOPMed gnomAD
CA1021436 rs765788012	208	K>Q		No	ClinGen ExAC gnomAD

No associated diseases with Q9BRV8

No regional properties for Q9BRV8

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9BRV8

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

2 GO annotations of molecular function

Name	Definition
protein kinase binding	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
small GTPase binding	Binding to a small monomeric GTPase.

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9CPR7	Sike1	Suppressor of IKBKE 1	Mus musculus (Mouse)	PR
Q5FWT9	Sike1	Suppressor of IKBKE 1	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MSCTIEKILT	DAKTLLERLR	EHDAAAESLV	DQSAALHRRV	AAMREAGTAL	PDQYQEDASD
70	80	90	100	110	120
MKDMSKYKPH	ILLSQENTQI	RDLQQENREL	WISLEEHQDA	LELIMSKYRK	QMLQLMVAKK
130	140	150	160	170	180
AVDAEPVLKA	HQSHSAEIES	QIDRICEMGE	VMRKAVQVDD	DQFCKIQEKL	AQLELENKEL
190	200
RELLSISSES	LQARKENSMD	TASQAIK