Q5FWT9

PR
Gene name
Sike1 (Sike)
Protein name
Suppressor of IKBKE 1
Names
Suppressor of IKK-epsilon
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:362007
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-113 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5FWT9

Entry ID Method Resolution Chain Position Source
AF-Q5FWT9-F1 Predicted AlphaFoldDB

2 variants for Q5FWT9

Variant ID(s) Position Change Description Diseaes Association Provenance
rs198519985 64 M>T No EVA
rs3319627879 124 A>S No EVA

No associated diseases with Q5FWT9

No regional properties for Q5FWT9

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q5FWT9

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
small GTPase binding Binding to a small monomeric GTPase.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9BRV8 SIKE1 Suppressor of IKBKE 1 Homo sapiens (Human) PR
Q9CPR7 Sike1 Suppressor of IKBKE 1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MSCTIEKILT DAKTLLERLR EHDAAAESLV DQSAALHRRV AAMREAGAVL PEQYQEDASD
70 80 90 100 110 120
VKDMSKYKPH ILLSQENTQI RDLQQENREL WVSLEEHQDA LELIMSKYRK QMLQLMVAKQ
130 140 150 160 170 180
AVDAEPVLKA HQSHSAEIES QIDRICEMGA VMRRAVQVDD NQFCKIQEKL AQLELENKEL
190 200
RELLSISSES LQVGKESSVA PEAQTIR