Q99PU5
PR
Gene name |
Acsbg1 |
Protein name |
Long-chain-fatty-acid--CoA ligase ACSBG1 |
Names |
Acyl-CoA synthetase bubblegum family member 1, mBG1, Gonadotropin-regulated long chain acyl CoA synthetase, GR-LACS, Lipidosin |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:94180 |
EC number |
6.2.1.3: Acid--thiol ligases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q99PU5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q99PU5-F1 | Predicted | AlphaFoldDB |
46 variants for Q99PU5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs215206496 | 31 | L>V | No | EVA | |
| rs3389012427 | 55 | S>R | No | EVA | |
| rs243569411 | 57 | G>A | No | EVA | |
| rs3389019504 | 93 | P>S | No | EVA | |
| rs264176720 | 98 | R>H | No | EVA | |
| rs3400174641 | 108 | E>G | No | EVA | |
| rs3389047731 | 141 | K>I | No | EVA | |
| rs3399853171 | 156 | S>C | No | EVA | |
| rs3389012401 | 156 | S>N | No | EVA | |
| rs3399630132 | 157 | V>E | No | EVA | |
| rs3389041671 | 165 | P>R | No | EVA | |
| rs3389043493 | 191 | E>* | No | EVA | |
| rs3389041730 | 224 | P>S | No | EVA | |
| rs3389039072 | 225 | H>Y | No | EVA | |
| rs3389046564 | 241 | A>P | No | EVA | |
| rs3389038976 | 275 | V>M | No | EVA | |
| rs3389012416 | 278 | Y>C | No | EVA | |
| rs3389025543 | 282 | T>I | No | EVA | |
| rs3388994143 | 325 | L>I | No | EVA | |
| rs3389043570 | 329 | A>S | No | EVA | |
| rs3410464763 | 337 | T>I | No | EVA | |
| rs3389012368 | 341 | W>L | No | EVA | |
| rs3389047726 | 369 | H>Y | No | EVA | |
| rs3389054029 | 371 | G>* | No | EVA | |
| rs3389043575 | 374 | R>G | No | EVA | |
| rs3400184292 | 401 | A>P | No | EVA | |
| rs3389047667 | 406 | L>M | No | EVA | |
| rs3389019499 | 437 | L>V | No | EVA | |
| rs3389041667 | 442 | C>S | No | EVA | |
| rs3388994212 | 456 | T>S | No | EVA | |
| rs3389041749 | 472 | G>D | No | EVA | |
| rs3389041718 | 490 | L>F | No | EVA | |
| rs3389012359 | 495 | R>K | No | EVA | |
| rs3389048395 | 507 | Q>H | No | EVA | |
| rs3400154018 | 622 | T>P | No | EVA | |
| rs3400285157 | 626 | T>I | No | EVA | |
| rs3400089160 | 626 | T>P | No | EVA | |
| rs3399604258 | 627 | E>D | No | EVA | |
| rs3400285164 | 627 | E>G | No | EVA | |
| rs3389043556 | 630 | V>M | No | EVA | |
| rs3389043568 | 645 | E>V | No | EVA | |
| rs3389043558 | 646 | I>S | No | EVA | |
| rs3389039078 | 647 | V>M | No | EVA | |
| rs3389039060 | 651 | D>E | No | EVA | |
| rs3389053984 | 713 | D>E | No | EVA | |
| rs3389025614 | 715 | F>L | No | EVA |
No associated diseases with Q99PU5
1 regional properties for Q99PU5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Aminotransferase, class I/classII | 71 - 417 | IPR004839 |
Functions
| Description | ||
|---|---|---|
| EC Number | 6.2.1.3 | Acid--thiol ligases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoplasmic vesicle | A vesicle found in the cytoplasm of a cell. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| CoA-ligase activity | Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA. |
| long-chain fatty acid-CoA ligase activity | Catalysis of the reaction: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22. |
| very long-chain fatty acid-CoA ligase activity | Catalysis of the reaction: ATP + a very-long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a very long-chain fatty acid is a fatty acid which has a chain length greater than C22. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| long-chain fatty acid biosynthetic process | The chemical reactions and pathways resulting in the formation of long-chain fatty acids, any fatty acid with a chain length between C13 and C22. |
| long-chain fatty acid metabolic process | The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. |
| ovarian follicle atresia | A periodic process in which immature ovarian follicles degenerate and are subsequently re-absorbed. |
| response to glucocorticoid | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. |
| very long-chain fatty acid metabolic process | The chemical reactions and pathways involving a fatty acid which has a chain length greater than C22. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8W471 | AAE15 | Long-chain-fatty-acid--[acyl-carrier-protein] ligase AEE15, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPRGSEAGYC | CLSRDSNMPD | SRDDQQQGAS | LGTSQDNSQT | SSLIDGQTLS | KESPSHGLEL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SAPEKARAAS | LDGAEEALWT | TRADGRVRLR | LEPFCTQRPY | TVHQMFYEAL | DKYGNLSALG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FKRKDKWERI | SYYQYYLIAR | KVAKGFLKLG | LERAHSVAIL | GFNSPEWFFS | AVGTVFAGGI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VTGIYTTSSP | EACQYISHDC | RANVIVVDTQ | KQLEKILKIW | KDLPHLKAVV | IYQEPPPKKM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ANVYTMEELI | ELGQEVPEEA | LDAIIDTQQP | NQCCVLVYTS | GTTGNPKGVM | LSQDNITWTA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RYGSQAGDIQ | PAEVQQEVVV | SYLPLSHIAA | QIYDLWTGIQ | WGAQVCFADP | DALKGTLVNT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LREVEPTSHM | GVPRVWEKIM | ERIQEVAAQS | GFIRRKMLLW | AMSVTLEQNL | TCPSNDLKPF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TSRLADYLVL | ARVRQALGFA | KCQKNFYGAA | PMTAETQRFF | LGLNIRLYAG | YGLSESTGPH |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FMSSPYNYRL | YSSGRVVPGC | RVKLVNQDAD | GIGEICLWGR | TIFMGYLNME | DKTCEAIDSE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GWLHTGDMGR | LDADGFLYIT | GRLKELIITA | GGENVPPVPI | EEAVKMELPI | ISSAMLIGDQ |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RKFLSMLLTL | KCTLDPETSE | PTDSLTEQAV | EFCQRVGSKA | STVSEIVGQR | DEAVYQAIHE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| GIQRVNANAA | ARPYHIQKWA | ILQRDFSISG | GELGPTMKLK | RLTVLEKYKD | IIDSFYQEQK |
| Q |