Q8W471
PR
Gene name |
AAE15 (At4g14070, dl3075c, FCAALL.81) |
Protein name |
Long-chain-fatty-acid--[acyl-carrier-protein] ligase AEE15, chloroplastic |
Names |
Acyl-[acyl-carrier-protein] synthetase, Acyl-activating enzyme 15 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G14070 |
EC number |
6.2.1.20: Acid--thiol ligases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8W471
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8W471-F1 | Predicted | AlphaFoldDB |
118 variants for Q8W471
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_4_8118023_T_A | 6 | K>I | No | 1000Genomes | |
| ENSVATH06656635 | 13 | I>T | No | 1000Genomes | |
| ENSVATH14183287 | 25 | L>S | No | 1000Genomes | |
| ENSVATH14183287 | 25 | L>W | No | 1000Genomes | |
| ENSVATH11695414 | 35 | S>P | No | 1000Genomes | |
| ENSVATH02825607 | 38 | R>L | No | 1000Genomes | |
| ENSVATH02825606 | 39 | Q>H | No | 1000Genomes | |
| tmp_4_8117911_A_T | 43 | F>L | No | 1000Genomes | |
| ENSVATH06656634 | 48 | I>V | No | 1000Genomes | |
| ENSVATH02825605 | 49 | S>L | No | 1000Genomes | |
| ENSVATH00502000 | 50 | G>S | No | 1000Genomes | |
| ENSVATH06656633 | 51 | H>Q | No | 1000Genomes | |
| tmp_4_8117849_A_G | 64 | V>A | No | 1000Genomes | |
| ENSVATH06656631 | 64 | V>I | No | 1000Genomes | |
| tmp_4_8117412_T_G | 72 | E>A | No | 1000Genomes | |
| ENSVATH02825584 | 74 | K>R | No | 1000Genomes | |
| ENSVATH02825583 | 75 | P>Q | No | 1000Genomes | |
| ENSVATH02825579 | 85 | F>L | No | 1000Genomes | |
| tmp_4_8117374_A_C | 85 | F>V | No | 1000Genomes | |
| ENSVATH06656610 | 86 | S>P | No | 1000Genomes | |
| tmp_4_8117359_C_G | 90 | A>P | No | 1000Genomes | |
| ENSVATH00501994 | 94 | S>N | No | 1000Genomes | |
| ENSVATH09571281 | 94 | S>R | No | 1000Genomes | |
| tmp_4_8117341_A_T,AT | 96 | W>R | No | 1000Genomes | |
| ENSVATH06656609 | 97 | K>M | No | 1000Genomes | |
| ENSVATH00501993 | 105 | S>T | No | 1000Genomes | |
| tmp_4_8117295_C_G | 111 | G>A | No | 1000Genomes | |
| ENSVATH02825577 | 112 | D>N | No | 1000Genomes | |
| tmp_4_8117272_G_T | 119 | P>T | No | 1000Genomes | |
| tmp_4_8117266_G_A | 121 | H>Y | No | 1000Genomes | |
| tmp_4_8117262_T_C | 122 | D>G | No | 1000Genomes | |
| tmp_4_8117254_A_T | 125 | L>M | No | 1000Genomes | |
| tmp_4_8117250_T_C | 126 | K>R | No | 1000Genomes | |
| ENSVATH14183203 | 137 | L>S | No | 1000Genomes | |
| ENSVATH06656594 | 141 | E>V | No | 1000Genomes | |
| ENSVATH02825549 | 144 | R>L | No | 1000Genomes | |
| ENSVATH02825548 | 150 | A>V | No | 1000Genomes | |
| ENSVATH02825547 | 157 | F>Y | No | 1000Genomes | |
| ENSVATH11695202 | 162 | C>R | No | 1000Genomes | |
| tmp_4_8115868_C_A | 192 | Q>H | No | 1000Genomes | |
| ENSVATH11695111 | 195 | R>C | No | 1000Genomes | |
| ENSVATH02825536 | 195 | R>H | No | 1000Genomes | |
| tmp_4_8115384_C_A | 203 | V>F | No | 1000Genomes | |
| ENSVATH06656569 | 208 | E>D | No | 1000Genomes | |
| tmp_4_8115362_A_G | 210 | F>S | No | 1000Genomes | |
| ENSVATH11695039 | 247 | S>C | No | 1000Genomes | |
| tmp_4_8115219_T_C | 258 | S>G | No | 1000Genomes | |
| ENSVATH06656564 | 267 | D>G | No | 1000Genomes | |
| ENSVATH14183133 | 267 | D>N | No | 1000Genomes | |
| ENSVATH11695038 | 268 | T>N | No | 1000Genomes | |
| ENSVATH06656562 | 269 | R>K | No | 1000Genomes | |
| tmp_4_8115186_T_A | 269 | R>W | No | 1000Genomes | |
| ENSVATH02825527 | 283 | A>V | No | 1000Genomes | |
| ENSVATH11695036 | 302 | R>Q | No | 1000Genomes | |
| ENSVATH02825519 | 310 | H>Y | No | 1000Genomes | |
| ENSVATH11695002 | 317 | A>T | No | 1000Genomes | |
| tmp_4_8114506_C_T | 359 | D>N | No | 1000Genomes | |
| ENSVATH06656550 | 362 | R>W | No | 1000Genomes | |
| tmp_4_8114305_G_T | 385 | Q>K | No | 1000Genomes | |
| tmp_4_8114268_G_A | 397 | A>V | No | 1000Genomes | |
| ENSVATH06656545 | 400 | L>F | No | 1000Genomes | |
| tmp_4_8114241_G_A | 406 | A>V | No | 1000Genomes | |
| ENSVATH06656544 | 412 | R>G | No | 1000Genomes | |
| tmp_4_8114218_A_G | 414 | Y>H | No | 1000Genomes | |
| ENSVATH06656540 | 417 | M>L | No | 1000Genomes | |
| tmp_4_8114075_C_G | 424 | K>N | No | 1000Genomes | |
| ENSVATH11694891 | 424 | K>R | No | 1000Genomes | |
| ENSVATH11694891 | 424 | K>T | No | 1000Genomes | |
| ENSVATH14183129 | 426 | P>Q | No | 1000Genomes | |
| tmp_4_8114055_G_C | 431 | A>G | No | 1000Genomes | |
| ENSVATH00501956 | 454 | K>M | No | 1000Genomes | |
| ENSVATH11694889 | 462 | S>L | No | 1000Genomes | |
| ENSVATH02825504 | 468 | K>T | No | 1000Genomes | |
| ENSVATH14183127 | 494 | N>K | No | 1000Genomes | |
| tmp_4_8113647_C_T | 506 | C>Y | No | 1000Genomes | |
| ENSVATH00501952 | 510 | L>R | No | 1000Genomes | |
| ENSVATH14183084 | 515 | L>H | No | 1000Genomes | |
| tmp_4_8113227_T_C | 535 | N>S | No | 1000Genomes | |
| ENSVATH11694817 | 540 | P>R | No | 1000Genomes | |
| tmp_4_8113185_C_T | 549 | R>K | No | 1000Genomes | |
| tmp_4_8113155_T_C | 559 | K>R | No | 1000Genomes | |
| ENSVATH06656523 | 562 | S>T | No | 1000Genomes | |
| tmp_4_8112947_T_A | 576 | T>S | No | 1000Genomes | |
| tmp_4_8112935_C_T | 580 | G>S | No | 1000Genomes | |
| ENSVATH11694815 | 581 | W>* | No | 1000Genomes | |
| ENSVATH11694704 | 581 | W>C | No | 1000Genomes | |
| ENSVATH02825485 | 587 | S>P | No | 1000Genomes | |
| ENSVATH00501944 | 588 | K>R | No | 1000Genomes | |
| ENSVATH14183080 | 592 | R>C | No | 1000Genomes | |
| tmp_4_8112890_C_T | 595 | G>R | No | 1000Genomes | |
| tmp_4_8112883_A_G | 597 | V>A | No | 1000Genomes | |
| tmp_4_8112884_C_A | 597 | V>F | No | 1000Genomes | |
| tmp_4_8112878_C_T | 599 | V>I | No | 1000Genomes | |
| ENSVATH14183079 | 614 | E>V | No | 1000Genomes | |
| ENSVATH02825477 | 617 | E>A | No | 1000Genomes | |
| ENSVATH11694700 | 627 | R>G | No | 1000Genomes | |
| ENSVATH02825475 | 636 | V>I | No | 1000Genomes | |
| ENSVATH02825470 | 662 | T>I | No | 1000Genomes | |
| tmp_4_8112488_G_A | 663 | S>F | No | 1000Genomes | |
| tmp_4_8112489_A_T | 663 | S>T | No | 1000Genomes | |
| tmp_4_8112449_C_T | 676 | R>K | No | 1000Genomes | |
| tmp_4_8112366_T_C | 679 | T>A | No | 1000Genomes | |
| tmp_4_8112363_A_C | 680 | S>A | No | 1000Genomes | |
| ENSVATH00501941 | 681 | E>A | No | 1000Genomes | |
| ENSVATH00501941 | 681 | E>V | No | 1000Genomes | |
| ENSVATH06656506 | 682 | C>F | No | 1000Genomes | |
| tmp_4_8112353_G_A | 683 | S>L | No | 1000Genomes | |
| ENSVATH06656505 | 684 | F>I | No | 1000Genomes | |
| ENSVATH00501939 | 693 | D>A | No | 1000Genomes | |
| tmp_4_8112324_C_G | 693 | D>H | No | 1000Genomes | |
| ENSVATH00501939 | 693 | D>V | No | 1000Genomes | |
| ENSVATH06656501 | 699 | D>H | No | 1000Genomes | |
| tmp_4_8112199_T_G | 703 | M>L | No | 1000Genomes | |
| ENSVATH00501936 | 720 | E>D | No | 1000Genomes | |
| ENSVATH02825461 | 720 | E>Q | No | 1000Genomes | |
| ENSVATH06656498 | 722 | I>F | No | 1000Genomes | |
| ENSVATH06656496 | 727 | S>G | No | 1000Genomes | |
| ENSVATH00501935 | 727 | S>N | No | 1000Genomes |
No associated diseases with Q8W471
Functions
| Description | ||
|---|---|---|
| EC Number | 6.2.1.20 | Acid--thiol ligases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloroplast | A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. |
| chloroplast envelope | The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space. |
| plastid | Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| long-chain fatty acid [acyl-carrier-protein] ligase activity | Catalysis of the reaction: ATP + an acid |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| fatty acid biosynthetic process | +The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. |
| fatty acid elongation | The elongation of a fatty acid chain by the sequential addition of two-carbon units. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q99PU5 | Acsbg1 | Long-chain-fatty-acid--CoA ligase ACSBG1 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQIRLKPDYS | FFIASSSTMA | STSSLGPSTL | LSYGSPSRQF | PDFGFRLISG | HESVRIPSFR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RFRVHCESKE | KEVKPSSPFL | ESSSFSGDAA | LRSSEWKAVP | DIWRSSAEKY | GDRVALVDPY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HDPPLKLTYK | QLEQEILDFA | EGLRVLGVKA | DEKIALFADN | SCRWLVSDQG | IMATGAVNVV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RGSRSSVEEL | LQIYRHSESV | AIVVDNPEFF | NRIAESFTSK | ASLRFLILLW | GEKSSLVTQG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MQIPVYSYAE | IINQGQESRA | KLSASNDTRS | YRNQFIDSDD | TAAIMYTSGT | TGNPKGVMLT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HRNLLHQIKH | LSKYVPAQAG | DKFLSMLPSW | HAYERASEYF | IFTCGVEQMY | TSIRYLKDDL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KRYQPNYIVS | VPLVYETLYS | GIQKQISASS | AGRKFLALTL | IKVSMAYMEM | KRIYEGMCLT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KEQKPPMYIV | AFVDWLWARV | IAALLWPLHM | LAKKLIYKKI | HSSIGISKAG | ISGGGSLPIH |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VDKFFEAIGV | ILQNGYGLTE | TSPVVCARTL | SCNVLGSAGH | PMHGTEFKIV | DPETNNVLPP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GSKGIIKVRG | PQVMKGYYKN | PSTTKQVLNE | SGWFNTGDTG | WIAPHHSKGR | SRHCGGVIVL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| EGRAKDTIVL | STGENVEPLE | IEEAAMRSRV | IEQIVVIGQD | RRRLGAIIIP | NKEEAQRVDP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ETSKETLKSL | VYQELRKWTS | ECSFQVGPVL | IVDDPFTIDN | GLMTPTMKIR | RDMVVAKYKE |
| EIDQLYS |