AiPD: Autoinhibited Protein Database

Gene name	Slc24a3 (Nckx3)
Protein name	Sodium/potassium/calcium exchanger 3
Names	Na(+)/K(+)/Ca(2+)-exchange protein 3, Solute carrier family 24 member 3
Species	Mus musculus (Mouse)
KEGG Pathway
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

360-434 (Predicted disordered autoinhibitory region) PR

360-434 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q99PD7-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs251829340	9	C>R	No	EVA
rs3392358480	31	S>P	No	EVA
rs1132196253	43	R>*	No	EVA
rs3388593411	59	K>R	No	EVA
rs3413147281	73	L>V	No	EVA
rs251900013	81	Q>R	No	EVA
rs3392368207	105	R>P	No	EVA
rs3392338893	106	Q>L	No	EVA
rs3388600887	135	L>M	No	EVA
rs3388600835	161	P>Q	No	EVA
rs3388595451	174	K>E	No	EVA
rs3388591425	243	L>I	No	EVA
rs3392341548	255	K>KVKHTACVLLTSRYR	No	EVA
rs3388598519	317	A>V	No	EVA
rs3388596268	341	T>I	No	EVA
rs3388584037	344	S>T	No	EVA
rs1133186620	372	I>F	No	EVA
rs1133574570	373	K>Q	No	EVA
rs3388592828	392	R>G	No	EVA
rs3388589123	499	M>I	No	EVA
rs3388584042	618	F>L	No	EVA

Type	Name	Position	InterPro Accession
domain	Sodium/calcium exchanger membrane region	113 - 254	IPR004837-1
domain	Sodium/calcium exchanger membrane region	478 - 629	IPR004837-2

		Description
EC Number
Subcellular Localization	Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cell periphery	The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
calcium channel activity	Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
calcium, potassium:sodium antiporter activity	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in).
symporter activity	Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.

Name	Definition
bone mineralization	The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue.
calcium ion transmembrane transport	A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
cation transport	The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
cellular calcium ion homeostasis	Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
negative regulation of gene expression	Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of gene expression	Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
potassium ion transmembrane transport	A process in which a potassium ion is transported from one side of a membrane to the other.
sodium ion transmembrane transport	A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9UI40	SLC24A2	Sodium/potassium/calcium exchanger 2	Homo sapiens (Human)	PR
Q9HC58	SLC24A3	Sodium/potassium/calcium exchanger 3	Homo sapiens (Human)	PR
Q8CGQ8	Slc24a4	Sodium/potassium/calcium exchanger 4	Mus musculus (Mouse)	PR